Neuroscience Meeting Planner Now Available
The Preliminary Program and Neuroscience Meeting Planner for Neuroscience 2014 are available.

At the 2012 Meeting I learned that the microRNA/messenger RNA balance had emerged during the past decade to be the most likely regulator of all downstream effects on cell type differentiation. That inspired me to focus on what I knew about RNA-mediated events and put what we detailed about them in our 1996 Hormones and Behavior review into the context of a this model.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

Additional examples of nutrient-dependent pheromone-controlled cell type differentiation will be presented at the 2014 meeting. The link from nutrient-dependent RNA-directed DNA methylation to epigenetic effects on cell type differentiation and behavior becomes clearer in these selected presentations.

DNA methylation mediates plasticity of circadian behavior

Epigenetic and transcriptional dysregulation in prodromal Huntington’s disease

A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons

Chronic stress induces epigenetic modification to the mPFC, OFC, and HPC of adult rats

Role of DNA methylation in the synaptic and behavioral effects of long-term severe stress

Reversing the behavioral phenotypes in fmr1 KO by the reduction of potassium channel, Kv4.2

Repeated social stress affects DNA methylation of genes associated with CRH/UCN3, arginine-vasopressin and renin-angiotensin systems in adult mouse hippocampus

The long non-coding rna malat-1 is involved in learning and memory formation

Histone methylation and ubiquitination are critical epigenetic regulators of memory reconsolidation

MicroRNA expression in the early postnatal hippocampus of the rat differs between the sexes and is regulated by estradiol and DNA methylation

Gluten and casein-derived opiate peptides alter redox status and produce epigenetic-based differences in gene expression

In utero lead (Pb) exposure and neuron-specific DNA methylation changes in mice

Alternative splicing and DNA methylation in the developing human brain

The DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene are potent diagnostic biomarker in psychiatric disorders

Maternal infection in mice leads different DNA methylation and gene expression between male and female offspring

Methyl supplementation via L-Methionine attenuates addictive-like behaviors in rats and blocks c-Fos activation in the reward circuit following cocaine-primed reinstatement

Prefrontal cortical deletion of DNA methyltransferases Dnmt1 and Dnmt3a induces anhedonia

Gene by environment interaction on post-traumatic stress disorder. Role of genetic and epigenetic differences in FKBP5

Genomic DNA methylation program of a neural stem cells differentiation

Long-lasting alterations in DNA methylome during posttraumatic epileptogenesis

Sex differences of blood in DNA methylation

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Also, place your search strategy on GnRH into the context of Feedback loops link odor and pheromone signaling with reproduction For example: “Indications that GnRH peptide plays an important role in the control of sexual behaviors suggest that pheromone effects on these behaviors might also involve GnRH neurons.” p 683.

The link from pheromones to epigenetically effected hormones that affect hormone-organized and hormone activated behavior is represented in the abstract linked here: RNA-sequencing after translating ribosomal affinity purification (TRAP) identifies in vivo gene expression differences in CA3 neurons of mice subjected to early life stress (ELS) 

Here is an abstract excerpt that appears to our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior, and its representations of RNA-mediated sex differences in cell types to the presentations on RNA-directed DNA methylation, and RNA-mediated events that link amino acid substitutions to species-specific sex differences in behavior:

Epigenetic modifications to the DNA imprint early life environment and experience onto the genome. Emerging evidence suggests the default female pattern involves epigenetic repression of the male genome which is emancipated by gonadal steroid inhibition of DNMT activity and subsequent demethylation of key genes, allowing for their expression.

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