The Architecture of a Scrambled Genome Reveals Massive Levels of Genomic Rearrangement during Development

Excerpt: “Genome-wide DNA rearrangements are most exaggerated in ciliates, particularly in the model organism Oxytricha trifallax, which programs not only DNA deletion, but also total reorganization, through RNA-mediated events (Fang et al., 2012; Nowacki et al., 2008). ”

My comment: The RNA-mediated events that lead to DNA rearrangements were reported as:

In one of nature’s innovations, a single cell smashes and rebuilds its own genome

Excerpt: “Previous work in Landweber’s lab—a 2012 publication in Cell and a 2008 paper in the journal Nature—showed that millions of noncoding RNA molecules from the previous generation direct this undertaking by marking and sorting the DNA pieces in the correct order.”

See my comments to the physorg.com site about the link from noncoding RNAs to DNA and chromosomal rearrangements.

Moving forward.

MinION USB stick gene sequencer finally comes to market

By John Hewitt on September 19, 2014 at 2:10 pm

Excerpt: “A final, cutting-edge new example highlights just how far some cells, and creatures, go to reconfigure their original “genome” throughout their lives. Every time a bizarre organism known as Oxytricha trifallax has a sexual encounter, it decrypts its own DNA and builds an entirely new version together with its partner. Strangely, there is no actual reproduction involved in these encounters, just exchange of DNA. Such extreme genetic rewiring is now just beginning to be witnessed, much less understood.”

My comment: Re: Oxytricha trifallax.

John Hewitt has done the unthinkable. He linked starvation in single-celled organisms with sexually differentiated cell types to RNA-mediated chromosomal rearrangements in humans via an accurate portrayal of what is known about the technology of human genome sequencing.

Conserved molecular mechanisms that link the epigenetic landscape to the physical landscape of DNA in the organized genomes of all species. Hewitt’s report shows what happens to evolutionary theory when biological facts are presented that link microbes to man. Simply put, theories that link mutations to the evolution of biodiversity are refuted by the fact that nutrient-dependent RNA-directed DNA methylation and amino acid substitutions link chromosomal rearrangements via the control of reproduction via species-specific pheromones.

The pheromones are metabolites of nutrients, which means that the physiology of reproduction is controlled by nutrient uptake, which leads to amino acid substitutions that are fixed in the genomes of all species via nutrient-dependent pheromone-controlled reproduction, not via mutations, natural selection or any other ridiculous theoretical explanation touted by evolutionary theorists.

Meanwhile, some researchers are still looking for genetic differences in cancer subtypes as if they did not know the subtypes result from RNA-mediated events, but lack of fixation of the amino acid substitutions that differentiate cell types. See for example: New visualization software uncovers cancer subtypes. The cancer subtypes consist of undifferentiated cell types due to mutations and lack of DNA repair via RNA-mediated events.

See also: Pulses of olfactory/pheromonal input

John Hewitt is the only science journalist I know who may have the knowledge required to link biophysically-constrained epigenetically-effected cell type differentiation via Luca Turin’s Molecular Vibration-Sensing Component in Human Olfaction from the de novo creation of olfactory receptor genes to the differentiation of cell types in species from microbes to man via conserved molecular mechanisms.

See also: Exploding genomes and chromosomal rearrangements via RNA-mediated events and 50+ other mentions of chromosomal rearrangements in my blog posts and 100+ posts about RNA-mediated events.

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