RNA-mediated genetic engineering (Part 2)

By: James V. Kohl | Published on: October 4, 2014

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WATCH: Bill Nye the Science Guy predicts end of creationism is nigh

Excerpt: “Best known as Bill Nye the Science Guy, the 58-year-old educator, TV personality and author lamented the lingering myth that the universe is a product of divine creation.”
My comment: Evolutionary theorists have not described a biologically-based evolutionary event that links one species to the evolution of another. The myth of evolution was exposed via the fact that Richard Lenski’s bacteria and Michael Desai’s yeasts did not mutate their DNA to become another species of microbe. However, theorists deny or ignore experimental evidence of how quickly RNA-mediated events lead from the epigenetic landscape to the physical landscape of DNA in the organized genomes of all created species from microbes to monkeys.
For example, see: Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
Excerpt: “… we successfully achieve precise gene targeting in cynomolgus monkeys. We also show that this system enables simultaneous disruption of two target genes (Ppar-γ and Rag1) in one step, and no off-target mutagenesis was detected by comprehensive analysis. Thus, coinjection of one-cell-stage embryos with Cas9 mRNA and sgRNAs is an efficient and reliable approach for gene-modified cynomolgus monkey generation.”
My comment: If you don’t know what sgRNAs are, see Subgenomic mRNA
This RNA-mediated “simultaneous disruption of two target genes” has implications for simultaneous protein–RNA, RNA–RNA, and nutrient-dependent DNA-mediated interactions throughout all organized genomes because the organization of genomes is controlled by the physiology of reproduction.
It is important to note that “…no off-target mutagenesis was detected by comprehensive analysis.” No mutagenesis attests to the fact that conserved molecular mechanisms link creation, not mutations, to biodiversity in species from microbes to man .
Simply put, the scientists have reaffirmed what the Christian Bible says about an “…efficient and reliable approach for gene-modified cynomolgus monkey generation.” See Genesis 9:7 KJV “be ye fruitful, and multiply…” (Genesis is the process or mode of origin, i.e., the generation of animals like monkeys.)
Evolutionary theorists continue to avoid questions about how the generation of monkeys via mutations was controlled so that a mutated gene could lead from one modified monkey to evolution of a new species of monkey. Thus, with no need to address anything except their foolish claims, we can ask theorists: If mutations lead to the evolution of biodiversity manifested in the morphological and behavioral phenotypes of one monkey, what stops the mutations in individual monkeys so that monkey friends become a species?
Clearly the answer to the question is species-specific pheromone-controlled nutrient-dependent RNA-mediated events. That’s where the gene-centric view touted by evolutionary theorists makes no sense.
If any theorist seems to have an answer that makes sense based on what is known from experimental evidence of biologically-based cause and effect, there may be some basis for another debate between pseudoscientists like “The Science Guy” and Creationists. For example, Creationists have known this since Dobzhansky (1973): “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.”
Unfortunately, that fact was placed into the context of evolutionary theory. Dobzhansky could not have known about how RNA-mediated events link the amino acid substitutions to cell type differentiation in all cells of all individuals of all species. However, the fact that a single nutrient-dependent amino acid substitution can differentiate all the cell types of all individuals in three different species can be viewed in the context of what is known about the “…efficient and reliable approach for gene-modified cynomolgus monkey generation.”
Nutrient-dependent “…disruption of two target genes…” is all that’s required. It leads to RNA-mediated differences in cell types and pheromone-controlled reproduction without the pseudoscientific nonsense of mutagenesis and theories about the evolution of biodiversity.
Experimental evidence now shows that the genesis of biodiversity is controlled. If Bill Nye or any other “Science Guy” thinks it is not controlled and that biodiversity somehow evolved, there is a book about what actually occurred, and also the journal article published on February 13, 2014, that confirms how gene-modified cynomolgus monkey generation occurs in the lab.
I’ve quoted from the book and the article so that their content can be debated in the context of what the Creationist, Dobzhansky said, which bears repeating: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.”
Moving forward:
“Research in Biological Control combines biology, engineering, physics, and computer science to decipher how living cells and organisms control complex behaviors through collective interactions among large numbers of components. Understanding the governing principles behind biological control will lead to new approaches for restoring physiological functions disrupted by disease and aging. It will also enable new strategies for engineering robots that build and work collectively like living cells.”
Living in the past:
“…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world. In this view of evolution there is no need of considering teleological elements.”