Summary: Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth

Stop this nonsense about de novo gene birth and you will help to stop the school shootings without more gun control.

See my presentation at the 2017 Precision Medicine Virtual Conference (2/15/17) Energy as information and constrained endogenous RNA interference

See also: Pat Sweeney et al (3/13/2017) Protein misfolding in neurodegenerative diseases: implications and strategies. 

A notable development is the creation of collaborative ecosystems that include patients, clinicians, basic and translational researchers, foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent, reverse or delay the progression of neurodegenerative proteinopathies.

For consideration of protein folding in the context of my life’s works, see: From de novo to “de nono”: most novel protein coding genes identified with phylostratigraphy represent old genes or recent duplicates

Claudio Casola refers “… to the putative de novo genes that failed to pass the validation criteria as the ‘de nono’ genes.” Use of the term ‘de nono’ to refute Pat Sweeney’s neo-Darwinian pseudosceintific nonsense is brilliant! For instance, all serious scientists know that protein folding chemistry is energy-dependent.
 
 

The structural diversity biophysically constrains viral latency and the constraints are referred to in the context of RNA-mediated autophagy. Autophagy clearly makes “de novo” gene creation a no-no term. That is why serious scientists are not likely to use the term de novo. It is like claiming that something automagically occurs.

In the context of what is known about energy-dependent cell type differentiation, see also:

Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis (2011)

and

Formulation and evaluation of anti-suicidal nasal spray of Thyrotropin releasing hormone (2017)

The fact that food odors and pheromones biophysically constrain physical and mental pathology via alternative splicings of RNA has been addressed in published works since 1990.

See for a recent example: RNA splicing is a primary link between genetic variation and disease (2016)

See for examples of constraints:

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults (E-pub 2014)

The catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects (2015)

Subsecond Regulation of Synaptically Released Dopamine by COMT in the Olfactory Bulb (2016)

The COMT Val158Met polymorphism exerts a common influence on avoidant attachment and inhibited personality, with a pattern of positive heterosis (2017)

In the context of energy-dependent constraints, the COMT VaL158Met amino acid substitution exemplifies the facts detailed in the context of: Hydrogen bonds directly detected for the first time (2017). The facts about hydrogen-atom transfer in DNA base pairs in solution have since been linked to all energy-dependent pheromone-controlled biodiversity in: Principles of Transgenerational Small RNA Inheritance in Caenorhabditis elegans (2017)

See also: Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study (1/15/2018)

Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior (2/20/2018)

Adjunctive nutrients in first‐episode psychosis: A systematic review of efficacy, tolerability and neurobiological mechanisms (3/21/18)

Reported as: Antioxidants and amino acids could play role in the treatment of psychosis 3/22/2018

See for comparison: March for Our Lives 3/24/18

Theme Gun violence awareness
Support of gun control

The focus on support of gun control ignores everything known to all serious scientists about biophysically constrained mental health and the virus-driven constraint-breaking mutations in the killers with guns. The future of school shootings depends on mental health treatment.

Why nutritional psychiatry is the future of mental health treatment

…29 clinical trials of antidepressant use in young people found no benefits at all. These trials revealed that instead of relieving symptoms of anxiety and depression, antidepressants caused children and young people to feel suicidal.

See for comparison: 7/25/13 Jay R. Feierman:

Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.

My understanding of biology is linked to my understanding of physics and chemistry via 40 years testing experience as a medical laboratory scientist (ASCP emeritus). Simply put, all organisms must eat and reproduce or species do not survive. The discovery of bacteria that eat electrons and create uranium ore was place into the context of this news:

Biologists discover electric bacteria that eat pure electrons rather than sugar, redefining the tenacity of life (2017)

The link from eating electrons to hydrogen-atom transfer in DNA base pairs in solution appears in the context of energy delivery to all cell types in organisms that have blood in their circulatory system. The claim that the human circulatory system evolved incorporates ‘de nono’ gene creation.

There is no such thing as de novo gene creation and ‘de nono gene creation’ can now be used in the context of post-publication ridicule of this model:

Basic Science Model of Blood as an Electron-Delivery Circuit Describes the Evolution of the Human Circulation (2017)

The anti-entropic virucidal energy of sunlight is the link from ecological variation to ecological adaptation in the context of the physiology of reproduction and biophysically constrained viral latency. Pseudoscientists will not stop trying to place that fact into the context of ridiculous neo-Darwinian theories.

Thankfully, ages 10+ can learn how energy-dependent life is biophysically constrained by playing the cell biology game “Cytosis” and the game that links energy-dependent changes from electrons to ecosystems in all living genera: “Subatomic“.

See my attempt to deliver that message in: There is no such thing as de novo control of electrons or the self-assembly of genes. (11/21/17)

But see: Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth

Stop this nonsense and you will help to stop the school shootings without more gun control.

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