See first: RNAi 2002 to AI 2021 (2) 12/30/21

The number of intelligent serious scientists who have integrated what is known about the physics, chemistry, and molecular biology of naturally occurring biophysically constrained microRNA-mediated viral endemicity and healthy longevity attests to the fact that most of them have been silenced.

Indeed, in response to many of my Facebook Posts, Facebook claims:

Independent fact-checkers investigate stories in a journalistic process meant to result in establishing the truth or falsity of the story.

Twitter uses algorithms to prevent dissemination of facts.

Fact-check this silenced claim: Every aspect of biophysically constrained life on Earth is microRNA-mediated.

See: MicroRNAs Involved in Oxidative Stress Processes Regulating Physiological and Pathological Responses 7/16/21

…we summarized the functions of miRNAs in several antioxidant genes. Understanding the crosstalk between miRNAs and oxidative stress-inducing factors during physiological and pathological cellular events may have implications for designing more effective treatments for immune diseases.

To reach an understanding of energy-dependent  microRNA-mediatged “crosstalk” and mRNA stability, see: Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21

From 1/5/21 until today, intelligent serious scientists have been Reexamining assumptions about miRNA-guided gene silencing 12/30/21

RNAi is a powerful mechanism for controlling mammalian gene expression. Studies of detailed molecular mechanisms for individual miRNAs will build a better understanding of how RNAi proteins, miRNAs, and cellular RNA targets act in concert to regulate gene expression. This foundation of rigorous research, coupled with an unbiased view about the boundaries of RNAi, will unlock discoveries and likely point the field in new directions both unexpected and exciting.

In the early 1990s, the late Robert L. Moss, urged me to “write the book” about the epigenetically-effected boundaries of RNAi, and my co-author, the late Robert T. Francoeur helped me to get a less-technical version published. See: The scent of eros: mysteries of odor in human sexuality (1995/2002). We linked food odors and pheromones from epigenetic effects on hormones to the affects of hormones on behavior. The late, Bruce S. McEwen told me that would be required to validate my model of top-down causation and confirmed that evidence of c-fos activation in GnRH neurosecretory neurons of the hypothalamus was the appropriate.

See: Pheromones (2010) from Stress Science: Neuroendocrinology

This is a revised version of the article by C A Dudley, A Kumar and R L Moss, Encyclopedia of Stress, First edition, volume 3

Now, the epigenetic effects of stress and integration with neuroendocrinology have linked Proton therapy for cancer to an example of what’s known to all intelligent serious scientists about how energy-dependent changes in angstroms to ecosystems. The energy-dependent changes have been linked from food odors and pheromones to “Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20

See also: MicroRNAs: Beyond Post-transcriptional Regulation of mRNAs 12/28/21

The discovery of new miRNAs and the identification of their targets and functions are fundamental to understanding the biological processes regulated by them, as well as the role they play in diseases. This present study researched miRNAs function at nuclear level and as circulating molecules.

Nothing happens to a cell type outside the context of energy-dependent microRNA-mediated autophagy and RNA-mediated cause and effect. See more than 1600 blog posts at RNA-mediated.com

See also: P53-regulated autophagy and its impact on drug resistance and cell fate 3/19/21

During autophagy, organelles and other intracellular components are degraded in autophagolysosomes and the autophagic breakdown products are recycled into metabolic and energy producing pathways needed for survival. P53 can promote or inhibit autophagy…

Every aspect of biophysically constrained microRNA-mediated healthy longevity can be compared to the claims in: Predicting Pseudogene-miRNA Associations Based on Feature Fusion and Graph Auto-Encoder 12/13/21

My summary:

Be the fool! Use the automagical “Auto-Encoder” to link interactions among pseudogenes and miRNAs that form a ceRNA -based mRNA network to regulate diseases – sans God’s Creation of energy-as-information and naturally attenuated biophysically constrained viral endemicity across kingdoms via the physiology of reproduction in Biblical Genesis.

For comparison, “Be the polymath!” See the “Research Topic” Machine Learning-Based Methods for RNA Data Analysis – Volume II for additional attempts to obfuscate the fact that all life on Earth is energy-dependent and microRNA-mediated by stem cell creation as detailed in MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20

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