achiral glycine

Molecular Diagnostics: What is unprotected life (4)

Pado, a fluorescent protein with proton channel activity can optically monitor membrane potential, intracellular pH, and map gap junctions Excerpt: Nature has developed a vast array of voltage-responsive proteins. To improve our ability to optimize the voltage sensitivity, kinetics, and signal size of GEVIs, an in silico search strategy was developed to identify potential voltage-sensing proteins since new genomes are routinely being sequenced. The use of a conserved amino acid motif in the second transmembrane segment of the voltage-sensing phosphatase…

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Mutisensory integration: watching the paradigm shift

Multisensory integration and causal inference in the brain Excerpt (with my emphasis):  It is largely unknown how the brain implements prior knowledge and expectations. Various mechanisms have been proposed such as spontaneous activity (Berkes et al., 2011), the fraction of neurons encoding a particular feature (Girshick et al., 2011), their response gain and tuning curves or connectivity and top-down projections from higher order areas (Rao and Ballard, 1999).” My comment: The brain implements prior knowledge and expectations through nutrient-dependent pheromone-controlled…

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Origin of life and cancer (1,2,3)

1) On the Origins of Life The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in all vertebrates. The role of food odors and hormone-controlled cell type differentiation in all vertebrates also links changes in the balance of viral microRNAs and…

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All of "like kind" in the (bigger) family

All in the (bigger) family Science 16 January 2015: Vol. 347 no. 6219 pp. 220-221 DOI: 10.1126/science.347.6219.220 by Elizabeth Pennisi Abstract: A decade of genetic data and other evidence has persuaded most researchers that insects and crustaceans, long considered widely separated branches of the arthropod family, actually belong together. The new arthropod tree puts hexapods—six-limbed creatures that include insects, springtails, and silverfish—as closer kin to crabs, lobster, shrimp, and crayfish than those “standard” crustaceans are to others such as seed…

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Glycine and GnRH: Am I being pedantic?

Posted to the FB page on 12/3/14 at Skeptics; Atheists; Realists; Agnostics; Humanists Stephen Hawking and Brian Cox take part in Monty Python sketch – video Excerpt: “I think you are being pedantic.” My comment: Some people may think I am being pedantic. My focus is not on physics; it is on the role of GnRH in cell type differentiation. My focus now extends from what is known about quantum physics, quantum smell, chirality, quantum biology, and quantum consciousness. What is known about chirality…

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