alternative splicing

From quantum physics to quantum souls (2)

May 29, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Summary: Natural selection for food energy-dependent codon optimality links the physiology of pheromone-controlled reproduction to all biodiversity on Earth via gene splicing and energy-dependent RNA-mediated fixation of amino acid substitutions. How humans and apes are different, and why it matters (2018) …the most distinctive feature of humanity is its ability to significantly alter ecosystems. That exemplifies human idiocy. The most distinctive features of humanity are biophysically constrained by what people eat and the physiology of pheromone-controlled reproduction. See: Nothing in Biology…

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Epigenetic inheritance of spatiotemporal regulation (3)

May 24, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Wen Zhou’s group has linked the creation of anti-entropic virucidal light from the quantized energy-dependent creation of microRNAs to the food energy-dependent neuroendocrine origins of human behavior via the pheromone-controlled physiology of reproduction and fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Simply put, she has linked quantum physics to quantum souls via what is known about biophysically constrained viral latency in the context of the cell biology game Cytosis and the future of biology.…

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Abiogenesis vs microRNA biogenesis (3)

April 20, 2018
James Kohl
Adaptations, base editing, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Reappraising the human mitochondrial DNA recombination dogma   My comment to BioRxiv (Hold on, this is waiting to be approved by BioRxiv) Thank you for helping to show what has been missing from neo-Darwinian theories and other claims that were based on de Vries 1902 definition of mutation. Theorists may now want to learn more about the energy-dependent molecular mechanisms of recombination. Most of them will not like the findings you have provided. The peer-review process is especially deadly to…

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Is meat protein unhealthy? (2)

April 5, 2018
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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See also: Microbiome-Grade DNA Extraction Kits …the thermal and chemical methods effectively lyse the gram-negative organisms and boost their population in the final profile, amplifying the bias. This suggests that all links from food energy-dependent de novo creation of the pheromone-controlled biophysically constrained bull sperm microRNAome have been misinterpreted in the context of virus-driven fescue toxicosis. The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression …the miRNA profile of mature ejaculated sperm may in fact…

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Is meat protein unhealthy? (1)

April 5, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Patterns of plant and animal protein intake are strongly associated with cardiovascular mortality Reported as: Meat protein is unhealthy, but protein from nuts and seeds is heart smart In the context of everything known about how the creation of anti-entropic virucidal light must be linked to all biodiversity on Earth, watch this ridiculous misrepresentation of the honeybee model organism. Food energy-dependent microRNA-mediated pheromone-controlled biophysically constrained viral latency is portrayed as if visual input was most important. Bee swarms work like…

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Complexity: Routes and Patterns (2)

April 1, 2018
James Kohl
Adaptations, Alternative Splicings, Ecology
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Role of RNA modifications in brain and behavior “Here, we summarize current knowledge of cellular consequences of RNA modifications, with a special emphasis on neuropsychiatric disorders. We present evidence for the existence of an “RNA code,” similar to the histone code, that fine‐tunes gene expression in the nervous system by using combinations of different RNA modifications.” Different RNA modifications were referred to as alternative splicings of pre-mRNA in the molecular epigenetics section of this 1996 Hormones and Behavior review: From…

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Conceptual critique: Innateness vs the death gene (1)

February 14, 2018
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Summary: The term innate is used in psychological explanations. The so-called explanations ignore facts about the light energy-dependent activation of endogenous substrates. The anti-entropic virucidal energy of sunlight links the endogenous substrates to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in all living genera. “Proximate mechanisms” and “evolution” are terms used by biologically uninformed theorists. That fact becomes perfectly clear in the context of  The conceptual critique of innateness (paywalled) One proposal is that innateness can…

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How to biophysically constrain the flu virus (1)

February 14, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, Subatomic
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Excerpt: John E Walker (Factor-dependent archaeal transcription termination) will probably explain the molecular mechanism of how ATP is made, which may be important to know for those who have learned how important ATP is by playing “Cytosis.” The creation of ATP can be linked to the creation of RNA and the prevention of messenger RNA degradation in the context of the Virus-mediated archaeal hecatomb in the deep seafloor. What the flu does to your body, and why it makes you…

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Plenty of Room at the Bottom

Cryo-EM: Linking spatial and conformational constraints

February 13, 2018
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation
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On Darwin Day (2018) Carl Zimmer suggested use of the twitter hashtag #Istudyevolution to report whatever aspect of biology people were studying. For example, Richard Lenski reported that he studied adaptation in E. coli. When I told others that ecological adaptation is nutrient-dependent and pheromone-controlled in species from microbes to humans, he blocked me from seeing his comments. Evidently he did not want people to know that he had been studying ecological adaptation for more than 2 decades but reporting…

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An evolutionary theory killer

A reversible TCA cycle in a thermophile

February 8, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News
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Make no mistake, pseudoscientists have stolen the soul of science for more than 20 years, with their ridiculous claims about mutations and evolution. For comparison, see: “…considering that we have just 3 such round Nos ‘100’ ‘1000’ ‘10000’, its just three out of all realistic possibilities, no? Admit its looks cool just bec. we calc in Dec system. History books claims was invented by ancient societies; but I think its evolution: We have 10 fingers!” My reply (SARCASM ALERT): Thanks.…

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