amino acid substitutions

Codon optimality vs systemic fraud (3)

A system of fraud exists that fails to link natural selection for energy-dependent codon optimality to The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents 5/17/22 This article belongs to the Special Issue Molecular Effects of Phytochemicals on Cholesterol Metabolism Genes Collectively, everything known to intelligent serious scientists about cell type differentiation across kingdoms can be linked from An Expanded Landscape of Unusually Short RNAs in 11 Samples…

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Codon optimality vs systemic fraud (1)

Two summaries of neo-Darwinian evolutionary theory: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. …yeast receptors trigger activation of heterotrimeric G proteins just as mammalian receptors do, this conserved signaling pathway must have been present in the common ancestor of yeast and humans. Unless you are a biologically uninformed theorist, see first Epistemic corruption (10) Watch for my next 10-part series on Codon optimality vs systemic fraud. I will link it to the fraudulent representations…

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Epistemic corruption (1)

Sunlight is the best disinfectant. That claim was echoed by Elon Musk on 5/3/22. If he stops the social media censorship of facts on Twitter, the epistemic corruption may end. Epistemic Corruption, the Pharmaceutical Industry, and the Body of Medical Science 3/8/21 It is not just that there is a body of medical science perverted by industry largesse. Instead, much of the corruption of medical science via the pharmaceutical industry happens through grafting activities: Pharmaceutical companies do their own research…

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RNA-mediated silencing (9)

WHO, the World Health Organization, thought you wouldn’t notice that your organizations were infiltrated by entitled feminists and stupid conspiracy theorists. See: Skirting the Matter of Feminism’s Culpability 4/4/22 “…true to feminist form, shifts to men and misogyny the blame for the epistemological collapse occurring in liberal democracies while ignoring the real culprit, feminism.” See also: RNA-mediated silencing (7) Three of the 4 articles that linked light-activated carbon fixation in cyanobacteria from microRNA-mediated protein folding chemistry across kingdoms were published…

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RNA-mediated silencing (7)

On 3/24/22 Reversing the miRNA -5p/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs linked quantum coherence to coherently organized biology and quantum souls via a change in the first nucleotide in miR-140. The energy-dependent change in the first nucleotide linked Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life (4/25/20) to Functions and underlying mechanisms of miR-650 in human cancers and Identifying the oncogenic potential of gene fusions exploiting miRNAs 3/24/22 Three of the 4…

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Photonics in Forensics (8)

Light-activated carbon fixation, the resurrection of life in pear trees, and the resurrection of life in daffodils exemplifies how God’s pH-dependent peptide synthesis at the origin of life ~6000 years ago links microRNA-mediated  protein folding chemistry to protection of all organized genomes from the virus-driven degradation of messenger RNA (mRNA). For instance, see: Integrative global co-expression analysis identifies Key MicroRNA-target gene networks as key blood biomarkers for obesity 3/10/22 They linked God’s Creation of energy-dependent transcription factor networks to computational…

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Photonics in Forensics (7)

Living with the Neanderthals 8/14/03 …Bear pleads for biologists to write clearly: “Don’t they realize how important it is to get the word out to everybody?” Social media censorship prevents people from learning the facts. All intelligent serious scientists and many intelligent people know that sunlight is beneficial in the context of biophotonics and forensics In the context of coronavirus pathology, this was stated clearly as US government experiments with simulations to show the coronavirus can ‘quickly’ be destroyed by…

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Photonics in Forensics (6)

The alphavirus 3′-nontranslated region: size heterogeneity and arrangement of repeated sequence elements 1/5/98 The 19-nt conserved sequence element directly adjacent to the poly(A) tract was found in all viruses The 19-nt conserved sequence element is biophysically constrained across kingdoms. No experimental evidence of top-down energy-dependent causation suggests that this 19-nt conserved sequence evolved via natural selection for mutations during billions to millions of years. For comparison, the conservation of one 22-nucleotide ring was reported in Footprints of a Singular 22-Nucleotide…

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microRNA-mediated biodiversity (6)

Tell me if you know a paleontologist or any other stupid theorist who is willing to discuss facts that link “Lessons from microRNA biology: Top key cellular drivers of Autosomal Dominant Polycystic Kidney Disease  to “… better understanding [of] the key processes resulting in pathophysiological changes that underlie disease.” Most theorists, especially paleontologists, seem willing to keep the diseases and their theories that link the virus-driven degradation of messenger RNA to the fossil record via extinctions and the Flood in…

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