amino acid substitutions

MicroRNA-mediated population control (3)

See first: MicroRNA-mediated population control (2) Theorists have not shown that any aspect of hydrogen-atom transfer in DNA base pairs in solution (video) and peptide synthesis at the origin of life occurs outside the context of visualizing a protonated RNA state that modulates microRNA-21 maturation For comparison, nearly 125,000 indexed published works link peptide synthesis at the origin of life to visualizing a protonated RNA state that modulates microRNA-21 maturation to biophysically constrained viral latency and healthy longevity across kingdoms…

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microRNA-mediated election cycles (6)

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis 7/13/21 Conclusions: Hyperglycaemia-induced trained immunity… suggests new targets for disease prevention and therapy. Reported on 7/14/21 as High blood sugar levels ‘reprogram’ stem cells Our study is the first to show that diabetes causes long-term changes to the immune system… By focussing too narrowly on a managing a person’s blood sugar levels we’re only addressing part of the problem. Every intelligent serious scientist in the world already knows…

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microRNA-mediated replication timing (5)

Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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Impeaching the God of Abraham (8)

2/22/21 In Case You Missed it. The cure for HIV and all other virus-driven pathology was announced today via an indexed publication found through my daily PubMed search for microRNA. Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters 12/31/20 & indexed on 2/22/21 announced “…a functional cure for HIV.” “The RNA polymerase III promoters H1, 7SK, and U6…” were linked to the cure or the effective treatment of all virus-driven diseases via…

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Protonated RNA interference vs stupid theories (4)

Remember, a vote for Joe Biden, and/or other Democrats, is a vote for more unnecessary suffering and premature deaths. See first: Protonated RNA interference vs stupid theories (3) See also: The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls 10/22/20 Comparison with previous reports on axolotl miRNAs unraveled common and unique members of the axolotl circulating miRNome. Overall, this work provides novel insights into non-mammalian aspects of circulating miRNA biology and expands the multi-omics toolkit for…

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pH-dependent viral latency (3)

Most Memorial Day 2020 celebrations and services were cancelled due to the well-orchestrated coronavirus crisis, which led to restrictions on our Constitutional rights. During the past two years, I’ve linked the eternal significance of light-activated microRNA biogenesis to our Constitutional rights. See the 10-part series: The eternal significance of microRNAs (10) and the 10-part series: The microRNA-mediated future of humanity (10) See also: pH-dependent viral latency and pH-dependent viral latency (2) Ages 10-14+ can learn what is known about pH-dependent…

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pH-dependent viral latency (2)

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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FDA’s ignorance: From roots to shoots (2)

Quantum coherence is linked to coherently organized biology in a well-ordered Universe, which is what happened in two recent publications. MicroRNAs organize intrinsic variation into stem cell states 3/5/20 MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 See also: FDA’s ignorance: From roots to shoots (1) 3/9/20 ‘Everything depends on where you got virus’: US & Russian top specialists explain odds of catching Covid-19 & surviving 3/8/20  “We are aware of at least 40 coronaviruses” One amino acid substitution…

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Virus-driven downsizing of the human brain (6)

See first: Virus-driven downsizing of the human brain (5) Scientists may need to seriously reconsider the cast-aside hypothesis that pathogens can play a part in diseases such as Alzheimer’s and Parkinson’s. 3/1/19 “Viruses are often ignored in relation to neurodegenerative diseases,” Yale University neurobiologist Anthony van den Pol tells The Scientist. “That’s in part because there’s no clear sign that a virus causes a neurodegenerative disease. But it might.” Some viruses can enter the body through the nose and mouth…

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Virus-driven genome engineering causes cancer?

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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