amino acid substitutions

microRNA-mediated replication timing (5)

July 2, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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Impeaching the God of Abraham (8)

February 28, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, Variations
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2/22/21 In Case You Missed it. The cure for HIV and all other virus-driven pathology was announced today via an indexed publication found through my daily PubMed search for microRNA. Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters 12/31/20 & indexed on 2/22/21 announced “…a functional cure for HIV.” “The RNA polymerase III promoters H1, 7SK, and U6…” were linked to the cure or the effective treatment of all virus-driven diseases via…

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Protonated RNA interference vs stupid theories (4)

November 2, 2020
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA interference, Subatomic
One Comment

Remember, a vote for Joe Biden, and/or other Democrats, is a vote for more unnecessary suffering and premature deaths. See first: Protonated RNA interference vs stupid theories (3) See also: The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls 10/22/20 Comparison with previous reports on axolotl miRNAs unraveled common and unique members of the axolotl circulating miRNome. Overall, this work provides novel insights into non-mammalian aspects of circulating miRNA biology and expands the multi-omics toolkit for…

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pH-dependent viral latency (3)

May 25, 2020
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA interference
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Most Memorial Day 2020 celebrations and services were cancelled due to the well-orchestrated coronavirus crisis, which led to restrictions on our Constitutional rights. During the past two years, I’ve linked the eternal significance of light-activated microRNA biogenesis to our Constitutional rights. See the 10-part series: The eternal significance of microRNAs (10) and the 10-part series: The microRNA-mediated future of humanity (10) See also: pH-dependent viral latency and pH-dependent viral latency (2) Ages 10-14+ can learn what is known about pH-dependent…

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pH-dependent viral latency (2)

May 24, 2020
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, What's in the News
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New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

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FDA’s ignorance: From roots to shoots (2)

April 6, 2020
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA interference
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Quantum coherence is linked to coherently organized biology in a well-ordered Universe, which is what happened in two recent publications. MicroRNAs organize intrinsic variation into stem cell states 3/5/20 MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20 See also: FDA’s ignorance: From roots to shoots (1) 3/9/20 ‘Everything depends on where you got virus’: US & Russian top specialists explain odds of catching Covid-19 & surviving 3/8/20  “We are aware of at least 40 coronaviruses” One amino acid substitution…

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Virus-driven downsizing of the human brain (6)

March 3, 2019
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed, Subatomic
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See first: Virus-driven downsizing of the human brain (5) Scientists may need to seriously reconsider the cast-aside hypothesis that pathogens can play a part in diseases such as Alzheimer’s and Parkinson’s. 3/1/19 “Viruses are often ignored in relation to neurodegenerative diseases,” Yale University neurobiologist Anthony van den Pol tells The Scientist. “That’s in part because there’s no clear sign that a virus causes a neurodegenerative disease. But it might.” Some viruses can enter the body through the nose and mouth…

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Virus-driven genome engineering causes cancer?

June 13, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response Inhibition of p53 prevents the damage response and increases the rate of homologous recombination… In the 1990’s, Abcam researchers discovered the cell death gene. Now see: Mechanisms of Recombination conference See also: P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells We demonstrated the toxic response is tp53-dependent and the toxic effect of tp53 severely reduces the efficiency of precise genome-engineering in hPSCs. Reported as:…

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The tipping point (revisited): 74,000 publications

June 12, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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President Trump and Kim Jong Un will probably discuss this fact: All serious scientists have learned that quantized energy-dependent microRNA biogenesis links everything known about the creation of sunlight from the physiology of food energy-dependent pheromone-controlled reproduction to viral latency and healthy longevity in the context of the creation of the innate immune system of bacteria. See also: The tipping point (revisited): 73,000 publications May 16, 2018 In less than one month, nearly 1000 publications have been added to the…

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Biologically uninformed science idiot: Self-defense (4)

June 4, 2018
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA Directed
No Comments

R. P. Feynman: Elementary Particles and the Laws of Physics (1986 Dirac memorial lecture) I Snippet: “The problem would be pushed back to Creation and God knows how that was done.” It has since become apparent to all serious scientists that God understands the transfer of photosynthetic energy. He linked the creation and transfer of energy across the quantum to classical border. Many biologically uninformed science idiots probably still think the border exists in the context of the problem of…

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