Amino Acid

Death cures theorist’s Amyotrophic Lateral Sclerosis (ALS).

March 15, 2018
James Kohl
Alternative Splicings, Autophagy, Diseases & Disorders, Human Brain, Neuronal Plasticity, Physics, RNA-mediated toxicity, Variations, What's in the News
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Stephen Hawking death: Was he the smartest man in the world? The media need superheroes in science just as in every sphere of life, but there is really a continuous range of abilities with no clear dividing line. For comparison: Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) A pathogenic mutation in D-amino acid oxidase (DAO) associated with familial ALS impairs D-serine metabolism and causes protein aggregation, autophagy and cell death…

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How to biophysically constrain the flu virus (1)

February 14, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, Subatomic
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Excerpt: John E Walker (Factor-dependent archaeal transcription termination) will probably explain the molecular mechanism of how ATP is made, which may be important to know for those who have learned how important ATP is by playing “Cytosis.” The creation of ATP can be linked to the creation of RNA and the prevention of messenger RNA degradation in the context of the Virus-mediated archaeal hecatomb in the deep seafloor. What the flu does to your body, and why it makes you…

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The “walking fish” walks straight from quantum physics to quantum souls (2)

January 1, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, Subatomic
One Comment

Summary: Cell fate conversion is food energy-dependent and pheromone-controlled in the context of the physiology of reproduction and autophagy, which links biophysically constrained viral latency to the differences in C. elegans and P. pacificus, a predatory nematode with teeth. Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans 1/01/2018 Summary This protocol describes how to study cellular processes during cell fate conversion in Caenorhabditis elegans in vivo. Using transgenic animals,allowing heat-shock promoter-driven overexpression of…

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Pheromones biophysically constrain base editing and RNA editing

November 2, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, What's in the News
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Summary: …they [Koonin’s group] substitute what they consider to be a plausible hypothesis. It places their observations into the context of a universal trend that is conserved in all life after the trend emerged, which was sometime before the last universal common ancestor of all extant organisms emerged and began to evolve. Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex Published online 18 October 2017 The vibrational theory of olfaction for the win Published 31 October 2017 Neuronal…

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Evolutionary theories of epigenetic drift

September 15, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data My summary: Outside the context of food energy-dependent biophysically constrained pheromone-controlled viral latency, mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. For example, age-differentially-methylated sites across the genome showed significant MA-consistent increases in heritability with age or significant DS-consistent decreases in heritability. Their results supposedly show that both MA and DS play a role in explaining aging and aging-related changes but…

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Energy-dependent physical and biophysical constraints (3)

July 25, 2017
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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See first: Energy-dependent physical and biophysical constraints (2) Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction. See: Feedback loops link odor and pheromone signaling with reproduction My comment to The Scientist: …trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an…

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Viruses in pathogenic variants disrupt alternative splicings

April 17, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Pathogenic variants that alter protein code often disrupt splicing Approximately 10% of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly. We present a large-scale characterization of exonic splicing mutations using a new technology that facilitates variant classification and keeps pace with variant discovery. Assay of nearly 5,000 mutations reveals roots of genetic splicing errors “Splicing errors can be very deleterious because instead of just changing one amino acid [the building block of a protein], it can…

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Biologically uninformed biologists fight back and lose

February 27, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, RNA Directed
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Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes 22 Feb 2017 A subset of tRNA genes shows low responsiveness to both environmental and cellular signals. Notably, this group contains at least one tRNA for each amino acid. Together these findings suggest the existence of a basal subset of housekeeping tRNA genes [36]. This concept is consistent with the mode of Maf1-mediated repression of actively transcribed tRNA genes in human cells subjected to serum starvation [104].…

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Francis S. Collins refutes theistic evolution

February 15, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
2 Comments

Criticisms of the nutrient-dependent pheromone-controlled evolutionary model Based on his writings, both published and unpublished, James Kohl presents an unsupported challenge to modern evolutionary theory and misrepresentations of established scientific terms and others’ research. — Andrew Jones, BA Editor’s note The 2013 review article by James Vaughn Kohl published in Socioaffective Neuroscience & Psychology and criticized in the above Letter to the Editor was subjected to standard peer review and the revised version was accepted by me after it had…

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Physicists: Desperate Acts (revisited)

February 6, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, Variations
One Comment

Physicists: Desperate Acts Light-induced endogenous RNA interference in bioluminescent microbes links Schrodinger’s claims in “What is LIfe?” (1944) from a light-to-chemical pathway of information exchange in all living genera via amino acid substitutions in supercoiled DNA. All subsequent works on the evolutionary synthesis failed to link  the anti-entropic virucidal energy of sunlight to Darwin’s “conditions of life” from the claims of Schrodinger (1944) or the claims of any other serious scientist. Indeed, in the case of higher animals we know…

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RSS Pheromones.com
  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
RSS Perfuming the Mind
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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