Amino Acid

Natural models inspire future therapeutics (2)

June 24, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis“ See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was…

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Ecological adaptations vs the randomness of evolution (4)

May 2, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology
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Biohacker Aaron Traywick Found Dead in DC Float Spa He was found face down in a flotation tank.  Timothy J. Cunningham (CDC) was found after he supposedly drowned in a river. Both had already linked the virus-driven degradation of messenger RNA to all pathology, and both probably knew that vaccines could not protect human populations from the threat of the next viral apocalypse. Researchers from South Korea recently exposed the facts. See: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination…

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Death cures theorist’s Amyotrophic Lateral Sclerosis (ALS).

March 15, 2018
James Kohl
Alternative Splicings, Autophagy, Diseases & Disorders, Human Brain, Neuronal Plasticity, Physics, RNA-mediated toxicity, Variations, What's in the News
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Stephen Hawking death: Was he the smartest man in the world? The media need superheroes in science just as in every sphere of life, but there is really a continuous range of abilities with no clear dividing line. For comparison: Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) A pathogenic mutation in D-amino acid oxidase (DAO) associated with familial ALS impairs D-serine metabolism and causes protein aggregation, autophagy and cell death…

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How to biophysically constrain the flu virus (1)

February 14, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, Subatomic
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Excerpt: John E Walker (Factor-dependent archaeal transcription termination) will probably explain the molecular mechanism of how ATP is made, which may be important to know for those who have learned how important ATP is by playing “Cytosis.” The creation of ATP can be linked to the creation of RNA and the prevention of messenger RNA degradation in the context of the Virus-mediated archaeal hecatomb in the deep seafloor. What the flu does to your body, and why it makes you…

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The “walking fish” walks straight from quantum physics to quantum souls (2)

January 1, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, Subatomic
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Summary: Cell fate conversion is food energy-dependent and pheromone-controlled in the context of the physiology of reproduction and autophagy, which links biophysically constrained viral latency to the differences in C. elegans and P. pacificus, a predatory nematode with teeth. Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans 1/01/2018 Summary This protocol describes how to study cellular processes during cell fate conversion in Caenorhabditis elegans in vivo. Using transgenic animals,allowing heat-shock promoter-driven overexpression of…

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Pheromones biophysically constrain base editing and RNA editing

November 2, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, What's in the News
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Summary: …they [Koonin’s group] substitute what they consider to be a plausible hypothesis. It places their observations into the context of a universal trend that is conserved in all life after the trend emerged, which was sometime before the last universal common ancestor of all extant organisms emerged and began to evolve. Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex Published online 18 October 2017 The vibrational theory of olfaction for the win Published 31 October 2017 Neuronal…

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Evolutionary theories of epigenetic drift

September 15, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data My summary: Outside the context of food energy-dependent biophysically constrained pheromone-controlled viral latency, mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. For example, age-differentially-methylated sites across the genome showed significant MA-consistent increases in heritability with age or significant DS-consistent decreases in heritability. Their results supposedly show that both MA and DS play a role in explaining aging and aging-related changes but…

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Energy-dependent physical and biophysical constraints (3)

July 25, 2017
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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See first: Energy-dependent physical and biophysical constraints (2) Emily Balskus Pins Down the Chemistry and Metabolism of Human Microbiomes Summary: The chemistry and metabolism of all microbiomes is food energy-dependent and pheromone-controlled via the physiology of reproduction. See: Feedback loops link odor and pheromone signaling with reproduction My comment to The Scientist: …trans-4-hydroxy-L-proline (Hyp) dehydratase, a newly discovered member of an abundant family of proteins, produced by gut bacteria, known as the glycyl radical enzymes, helps in metabolizing trans-Hyp, an…

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Viruses in pathogenic variants disrupt alternative splicings

April 17, 2017
James Kohl
Adaptations, Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Pathogenic variants that alter protein code often disrupt splicing Approximately 10% of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly. We present a large-scale characterization of exonic splicing mutations using a new technology that facilitates variant classification and keeps pace with variant discovery. Assay of nearly 5,000 mutations reveals roots of genetic splicing errors “Splicing errors can be very deleterious because instead of just changing one amino acid [the building block of a protein], it can…

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