Amino Acid

Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)

See also: Soil bacteria, bulls, cows, microRNAs, and mammary glands For comparison to everything known about how chemotaxis and phototaxis must be linked to supercoiled DNA via the nutrient-dependent pheromone-controlled physiology of reproduction in the context of the microRNA/messenger RNA balance and RNA-mediated cell type differentiation, see: Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functional Adaptation in a Cetacean Visual Pigment Excerpt: Using codon-based likelihood models, we also found significant evidence for positive selection…

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A failed theory of cancer: two more decades of pseudoscience

1995 Neo-Darwinism has failed as an evolutionary theory 2016 Cancer and the transformation of life: An Interview with Athena Aktipis Excerpt: Cancer is evolution taking place inside multi-cellular organisms. Cancer cells are perversely adaptive and proliferate faster than normal cells. Since evolution has no foresight, it doesn’t matter that the end result of cancer evolution is the death of the cancer along with its host. But cancer cells are subject to the same evolutionary pressures as other cells. Amazingly, only…

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A two-faced protein enables RNA-mediated DNA repair

Janus: …is the god of beginnings and transitions,[1] and thereby of gates, doors, doorways, passages and endings. He is usually depicted as having two faces, since he looks to the future and to the past. My comment: Nutrient-dependent beginnings of morphological and behavioral diversity are biophysically constrained by the physiology of species-specific RNA-mediated DNA repair in the context of reproduction. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Excerpt: Despite barely conserved primary sequences (Supplementary Fig.…

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Nutrient-dependent trophic analogs

Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps Excerpt: Our results identify the molecular mechanism of epigenetic inheritance as the main target for therapeutic treatments against the emergence of adaptive resistance. Finally, our theoretical framework unifies known and newly identified determinants… Conclusion: Our model provides an explanation for the emergence of adaptive resistance based on the cost and benefit of the biological characteristics of an efflux pump system. It does not only predict the…

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Theorists can’t understand biology

See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Rediscovering quantum behavior

Earlier today, George Ellis brought this to the attention of others. Quantum behaviour has been discovered in algae I thank him for calling attention to the requirement for an epigenetic trap that links the sun’s biological energy from atoms to ecosystems via RNA-mediated cell type differentiation in all living genera. Excerpt: They found that the two species that could turn the coherence off had a genetic mutation that led to the insertion of an extra amino acid in the protein…

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Can veterans and other prisoners escape pseudoscience?

Combating Evolution to Fight Disease “…an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.” Inside the drive to collect DNA from 1 million veterans and revolutionize medicine Excerpt 1) The U.S. Department of Veterans Affairs is gathering blood from 1 million veterans to sequence their DNA. This is one of the most ambitious projects ever undertaken to understand our genome. Excerpt 2) In January, President Obama announced plans for…

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Skip the politics; embrace the facts

It’s Not Brain Surgery, Ben Carson Excerpt: …“Heal Inspire Revive,” invokes an image of him pounding on the chest of a pulseless America. Whether or not he actually knows how to handle a crash cart of that size, many voters don’t seem to doubt that he can. And he doesn’t doubt it either. My comment: I do not expect anyone who understands what is currently known about how physics and chemistry are linked to the biophysically constrained conserved molecular mechanisms…

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700 million years of evolution?

Analysis of 5′ gene regions reveals extraordinary conservation of novel non-coding sequences in a wide range of animals Conclusion: It is our hope that each and every one of these regions will make interesting candidates for experimental analysis, helping to increase our understanding of regulation of gene expression, and particularly our understanding of regulatory elements in RNA. My comment: In other words, they hope what has already been detailed in the context of how nutrient-dependent microRNAs link the epigenetic landscape…

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