Amino Acid

RNA-mediated physics, chemistry, and molecular epigenetics (3)

May 9, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism reported as: Using microRNAs to target cancer cells By Dawn Hayward Conclusion:  MicroRNAs stand out from conventional gene-therapy-based approaches and have a niche in lipid metabolism. They can be designed specifically to target a gene and serve as modulators rather than on/off switches. Increased lipid formation and breakdown in cancer cells creates vulnerability that might be taken advantage of by microRNAs. In addition, cancer as a whole involves a…

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Energy dependent RNA-mediated immunity (5)

March 8, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Manfred Eigen (born May 9, 1927) is a German biophysical chemist who won the 1967 Nobel Prize in Chemistry for work on measuring fast chemical reactions. People are still touting his neo-Darwinian nonsense nearly 50 years later. It sometimes seems that nothing is known to the pseudoscientists about how the RNA-mediated innate immune system links nutrient-dependent RNA-mediated DNA repair to supercoiled DNA and  protection against virus-driven entropy. Supercoiled DNA links ecological variation to ecological adaptation and transgenerational epigenetic inheritance in…

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Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)

February 22, 2016
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Soil bacteria, bulls, cows, microRNAs, and mammary glands For comparison to everything known about how chemotaxis and phototaxis must be linked to supercoiled DNA via the nutrient-dependent pheromone-controlled physiology of reproduction in the context of the microRNA/messenger RNA balance and RNA-mediated cell type differentiation, see: Spectral Tuning of Killer Whale (Orcinus orca) Rhodopsin: Evidence for Positive Selection and Functional Adaptation in a Cetacean Visual Pigment Excerpt: Using codon-based likelihood models, we also found significant evidence for positive selection…

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A failed theory of cancer: two more decades of pseudoscience

January 14, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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1995 Neo-Darwinism has failed as an evolutionary theory 2016 Cancer and the transformation of life: An Interview with Athena Aktipis Excerpt: Cancer is evolution taking place inside multi-cellular organisms. Cancer cells are perversely adaptive and proliferate faster than normal cells. Since evolution has no foresight, it doesn’t matter that the end result of cancer evolution is the death of the cancer along with its host. But cancer cells are subject to the same evolutionary pressures as other cells. Amazingly, only…

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A two-faced protein enables RNA-mediated DNA repair

November 29, 2015
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Janus: …is the god of beginnings and transitions,[1] and thereby of gates, doors, doorways, passages and endings. He is usually depicted as having two faces, since he looks to the future and to the past. My comment: Nutrient-dependent beginnings of morphological and behavioral diversity are biophysically constrained by the physiology of species-specific RNA-mediated DNA repair in the context of reproduction. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Excerpt: Despite barely conserved primary sequences (Supplementary Fig.…

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Nutrient-dependent trophic analogs

November 27, 2015
James Kohl
RNA Directed
One Comment

Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps Excerpt: Our results identify the molecular mechanism of epigenetic inheritance as the main target for therapeutic treatments against the emergence of adaptive resistance. Finally, our theoretical framework unifies known and newly identified determinants… Conclusion: Our model provides an explanation for the emergence of adaptive resistance based on the cost and benefit of the biological characteristics of an efflux pump system. It does not only predict the…

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Theorists can’t understand biology

November 19, 2015
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Rediscovering quantum behavior

November 15, 2015
James Kohl
Adaptations, Light Energy, Model Organisms, Physics, RNA Directed, Variations
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Earlier today, George Ellis brought this to the attention of others. Quantum behaviour has been discovered in algae I thank him for calling attention to the requirement for an epigenetic trap that links the sun’s biological energy from atoms to ecosystems via RNA-mediated cell type differentiation in all living genera. Excerpt: They found that the two species that could turn the coherence off had a genetic mutation that led to the insertion of an extra amino acid in the protein…

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Can veterans and other prisoners escape pseudoscience?

November 12, 2015
James Kohl
Adaptations, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed, Variations
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Combating Evolution to Fight Disease “…an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.” Inside the drive to collect DNA from 1 million veterans and revolutionize medicine Excerpt 1) The U.S. Department of Veterans Affairs is gathering blood from 1 million veterans to sequence their DNA. This is one of the most ambitious projects ever undertaken to understand our genome. Excerpt 2) In January, President Obama announced plans for…

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