Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid 2/5/21 Orgel and Szostak introduced an amino group into 2′- and 3′-positions9, which enabled effective RNA copying due to acceleration of the ligation reaction10,11. Reported as: Origins of life could have started with DNA-like XNAs 4/6/21 …shorter L-aTNA fragments came together and linked up with each other on the longer L-aTNA template. Critically, this happened in the presence of a compound, called N-cyanoimidazole, and a metal ion, like manganese, both of…