Andrew Jones

Pheromones protect us from viruses (6)

The Origin of Species (1859) linked the observations of Charles Darwin from his “conditions of life” to all biodiversity on Earth via the physiology of reproduction in all species. Scientific progress across disciplines has since linked his claims to an effective treatment, protonated RNA interference, for virus-driven pathology. See: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 Our recent neutron crystallographic study of the ligand-free SARS-CoV-2 Mpro provided direct visualization of…

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Suffering and loss of life by “voting blue” (1)

See: “Lipid Encapsulation of Self-Replicating Ribozymes” For comparison to this stupid theory by Nurse Andrew Jones, see the STEM toy for ages 14+ Genotype Who will be the biggest loser? Kalevi Kull: Censorship & Royal Society Evo Event 7/3/16 Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge.”…

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The microRNA-mediated fight against COVID-19 (1)

History (1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. History (2) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (2014 unpublished) This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino…

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The microRNA-mediated future of humanity (7)

Until recently, particle physics could not be linked to coherently organized biology by arbitrarily large energies. But KB Whaley and others have linked quantum coherence to high energy completion and President Donald J. Trump’s claims about effective coronavirus treatment with remdesivir. See also: INDY inhibition attenuates diet-induced NASH  (March 2020) Conserved molecular mechanisms link the light-activated assembly of the microRNA-RNA-peptide nanocomplex from the plasma-membrane tricarboxylate transporter INDY (I’m Not Dead Yet) to effective treatment of coronavirus pathology with remdesivir. If…

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Energy-dependent RNA methylation (10)

Plexciton Dirac points and topological modes Reported as: Scientists design energy-carrying particles called ‘topological plexcitons’ Excerpt: This should eventually enable engineers to create plexcitonic switches to distribute energy selectively across different components of a new kind of solar cell or light-harvesting device. My comment: “Single-residue insertion switches the quaternary structure and exciton states of cryptophyte light-harvesting proteins” links their discovery to the complexity of energy-dependent epigenetically-effected biophysically constrained protein folding chemistry in all living genera. Two epigenetic traps are required…

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Somatic hypermutation vs RNA-mediated events

Change in environment can lead to rapid evolution, researchers say Excerpt: 135 genes evolved in response to the new environment. Most of the changes in the gene expression were internal and dealt with a fish’s biological processes such as metabolism, immune function and development. My comments: 1) Journal article excerpt: “… few studies have been able to capture the initial patterns of plasticity and subsequent adaptive divergence of traits in natural populations.” All experimental evidence links physics and chemistry via…

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The biologically-based origin of the mammalian placenta (2)

See also: The biologically-based origin of the mammalian placenta I’ll preface this follow-up on the origins of the mammalian placenta with comments that attest to foolishness of theoretical physicists who try to link Big Bang cosmology to neo-Darwinian theories about mutations and evolution. RPF Interviews Dr. Alexander Unzicker Excerpt 1)  “It annoys me too much to see another generation of physicists deterred by the dumb messy patchwork called the standard model of particle physics, that hides the basic problems physics…

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Are viruses microRNAs? (2)

The role of microRNAs in cell type differentiation can be compared in the context of the role of viruses and mutations that cause cancer. Facts provide a basis for explaining the biological basis of epigenetically-effected cell type differentiation in species from microbes to man. But first, those who are biologically uninformed must answer the question: Are viruses microRNAs? Andrew Jones aka anonymous_9001 is correct. Viruses are not microRNAs. anonymous_9001 5 / 5 (6) 11 hours ago Stupid question of the…

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Constrained evolution is ecological adaptation

See also: Unconstrained evolutionary innovability Ideas that evolution is not constrained can be compared to experimental evidence of biophysically constrained ecological adaptations. The most recent relevant open access published work from the Jakobsson lab is: TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells. This is a link to a prior publication (also open access): microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons Taken together these two published works extend our 1996 model of RNA-mediated cell type differentiation…

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Mutagenesis: Replacing facts with theories

Never mind the selfish gene – ribosomes are the missing link Excerpt: “All cells share three organelles, or internal structures, besides gene-containing chromosomes: ribosomes which contain the machinery for translating genetic information into the proteins that perform the cell’s work; a cell membrane that selectively permits materials in and out; and acidocalcisomes, which store and regulate the ions that drive the chemical reactions of life.” In his criticisms of my model of cell type differentiation, Andrew Jones (aka anonymous_9001 in…

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