Anna Di Cosmo

New Testament Book Cover Refutes Theistic Evolution

Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

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Dobzhansky 1973 and precision medicine

MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee Our findings point to miR-34-5p as novel regulatory component in the complex molecular cascade that governs insect segmentation and to a broader role of miRNAs in the early development due to the detection of mature transcripts from both 5p and 3p arms for several precursor miRNAs. Thus, this work encourages further investigation to pinpoint miRNAs as fine tuners of insect early development. Anna Di Cosmo‘s group took the…

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Optogenetics: Let there be virucidal light!

NIH Awards $1.4M Grant to Support Optogenetics Research Excerpt: Synaptic plasticity, learning and memory are regulated by protein signaling in the brain. Many forms of learning disabilities and other mental diseases may be caused by abnormal protein signaling. To address these brain disorders and diseases, it is crucial to understand on a molecular level the underlying processes within the brain that are involved in learning and memory.” My comment: When someone like Anna Di Cosmo, John Hewitt or Bruce McEwen…

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Did evolution autophosphorylate your kinases? (2)

Hecatombic evolution Deep-Sea Viruses Destroy Archaea Excerpt: Given the enormous scale of deep-sea ecosystems, the results indicate that archaea-virus relationships could be a major contributor to global biogeochemical cycles. My comment:  I know that Anna Di Cosmo​ and John Hewitt​ are able to link virus-driven energy theft to all pathology in all living genera via the conserved molecular mechanisms they have already placed into their proper perspective on natural selection for energy-dependent codon optimality, which links the innate immune system…

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The last RNA-mediated theory killer (2)

Autophagy (epigenetically effected by nutrient-energy and controlled by the physiology of reproduction) See for comparison: Virus-driven energy theft and epigenetically-effected autophagy Selleck Chem product use citations Excerpts: Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses. A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer. The number of citations to published works that link the use of…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Virus-driven energy theft: honeybee model

The Buzz about Honey Bee Viruses August 18, 2016 Similar to other co-evolving host—pathogen relationships, honey bee viruses have likely evolved mechanisms to overcome and/or evade bee immune responses. For example, several honey bee infecting Dicistroviruses (i.e., IAPV, KBV, and ABPV) encode a DvExNPGP motif at the 5′ terminus of their genomes, suggesting these honey bee-infecting viruses encode putative viral suppressors of RNAi similar to the Dicistroviruses Cricket paralysis virus and Drosophila C virus [52]. In addition, viruses may manipulate…

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Model vs theory: Progress report!

On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to…

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The Mind’s Eyes (revisited)

Author’s copy: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences (2007) Abstract: The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self.  Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response.  The organization and activation of this neuroendocrine response modulates the concurrent maturation of the mammalian neuroendocrine system, the reproductive system, and the central nervous system during the development of sexual preferences that…

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