anti-entropic

New anti-entropic microbes

Many New Microbe Molecules Discovered in Humans Excerpt 1) Because gut bacteria live without oxygen, they need electron transfer to survive. Metabolizing amino acids allows transfer of electrons, but produces large amounts of byproducts, including phenylacetic and phenylpropionic acids. These products, unlike RiPPs are able to go into the cells and the blood stream. There are many different metabolites, only some of which are understood. Many metabolites of these are made in large quantities. Conclusion: Much of what occurs in…

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Metabolic competition and cancer

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression Excerpt: “…glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity, glycolytic capacity, and IFN-γ production, thereby allowing tumor progression.” My comment: Does anyone know the difference between 1) a tumor that eats glucose and 2) viruses that steal nutrient-dependent energy from the cell types of all cells in all individuals of all living genera, which links viruses to perturbed RNA-mediated protein folding and…

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Genome sequencing, cadherins, and quantum consciousness

Brave new epigenomes: the dawn of epigenetic engineering Reported as: Opinion: Engineering the Epigenome Excerpt: . ..until recently, we were not able to assess the influence of individual marks on gene activity because it was only possible to alter chromatin marks globally through mutational approaches or pharmacological inhibition. My comment: Mutational approaches led to assumptions about cell type differentiation that failed to include the role of viruses, viral microRNAs,  and the nutrient-dependent microRNAs that prevent the accumulation of viral microRNAs…

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Cell types, SNVs, CNVs, and chromosomes

See also: A “new” code enables ecological adaptation For comparison, see: Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell Excerpt: Single-molecule and single-cell studies reveal behaviors that are hidden in bulk measurements (1, 2). In a human cell, the genetic information is encoded in 46 chromosomes. The variations occurring in these chromosomes, such as single-nucleotide variations (SNVs) and copy-number variations (CNVs) (3), are the driving forces in biological processes such as evolution and cancer. Such dynamic…

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Unraveling evolutionary pseudoscience

Evolutionary Psychology Is Neither Excerpt any work that posits an adaptive explanation for a feature, but calls it an “evolutionary” approach – much less “the” evolutionary approach – is likely to be of greater value to the study of rhetoric or narrative in human evolution[9] than to the study of human evolution itself. My comment: Evolutionary biology that is touted in the context of the “Modern Synthesis” is no better than evolutionary psychology. Any links from neo-Darwinian evolution to human…

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The stability of organized genomes (3)

See also: The stability of organized genomes; The stability of organized genomes (2) Nutrient-dependent/pheromone-controlled adaptive evolution: a model Excerpt from 6/14/13  …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. Global relationships in fluctuation and response in adaptive evolution Preprint pdf opens here Excerpt: It should…

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Epimutation.com: a domain of confusion

See: Epimutation.com Currently, there is no content. When content is added, it will almost undoubtedly further the cause of confusion that evolutionary theorists must use in attempts to prevent serious scientists from Combating Evolution to Fight Disease. Serious scientists use what is currently known about biologically-based cause and effect. Prepare yourself for more pseudoscientific nonsense about epimutations. Until then, see this: Researchers investigate effect of environmental epigenetics on disease and evolution Excerpt 1) …environmental factors are having an underappreciated effect…

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Light -induced nucleic acid-mediated gene duplication?

Because the process amplifies any sort of nucleic acid, such as genetic material, Lee said photonic PCR can expedite the investigation of not only human genes but also those of microbes, animals and plants. UC Berkeley bioengineers develop ultra-fast method to copy DNA using light Excerpt: The team’s method — termed photonic PCR — works by shooting light at an ultra-thin film of gold, which energizes the electrons floating at the surface of the film. The excited electrons start oscillating and emitting heat,…

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ASCP MLS certification

The American Society for Clinical Pathology (ASCP) is a professional association based in Chicago, Illinois encompassing 130,000 pathologists and laboratory professionals. (MLS is the acronym for Medical Laboratory Scientist) I received this notice today from the American Society for Clinical Pathology: Excerpt: Dear James V Kohl, MLS(ASCP)CM, Congratulations on successful completion of the ASCP Board of Certification (BOC) Certification Maintenance Program. Your MLS certification is now valid through August 31, 2018. You will receive a new CMP wall certificate within…

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Viruses, amino acids, and somatic cell types (2)

Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain Excerpt: The RNA-seq data enabled us to detect a positive correlation between developmental changes in the magnitude of parental biases and overall gene expression for most imprinted genes. Conclusion: At the level of the organism, our data uncover how paternal and maternal alleles of Bcl-x make vastly different contributions to brain development, a result that has profound implications for the analysis of parentally-inherited polymorphisms in human health. Reported…

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