atoms to ecosystems

Nutrient-dependent autophagy

October 13, 2016
James Kohl
Adaptations, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA methylation, Variations
One Comment

Autophagy: cellular and molecular mechanisms Excerpt: Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. My comment: Autophagy is energy-dependent See for example: Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency…

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Base pairs, olfaction and RNA thermometers

September 22, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Consciousness is simply food rearranged

September 19, 2016
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, Variations
One Comment

The claim that consciousness is simply food rearranged can be placed into a historical perspective that crosses more than 70 years. Historical perspective: (1944) What Is Life? Excerpt: Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded,…

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Light energy-dependent active motifs

September 14, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Active Motif claims that Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. See how the role of light is portrayed in LightSwitch™ Luciferase Assay System (with my emphasis) Excerpt 1) Combined with our large collection of miRNA Mimics and Inhibitors, you have everything needed to study miRNA-3´UTR interactions, validate miRNA targets, measure RNA stability, translation efficiency and the functional impact of miRNAs on a gene-by-gene basis. Excerpt 2) The…

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How did the innate immune system evolve?

September 8, 2016
James Kohl
RNA Directed
One Comment

Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites Abstract excerpt: Why would a system exist that reduces the vigor of potential mates prior to mating? Addressing this question could provide insights into mechanisms and evolution of sexual conflict and reveal sensory inputs that regulate aging. Highlights excerpt: An unknown signal accelerates larval development, specifically the onset of puberty Reported as: Male chemistry primes females for reproduction—but at a cost “There is a fine balance between reproduction and…

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The Aquatic Ape: New evidence?

September 8, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, Variations
One Comment

The Waterside Ape BBC Radio 4 Publicity Sir David Attenborough considers whether new evidence will help a once widely ridiculed theory of human origins move towards to mainstream acceptance. In 1960, the eminent Oxford marine biologist Sir Alister Hardy proposed a revolutionary idea: that our human ancestors had not started their existence on the wide savannahs of Africa, but had become accustomed to living alongside water – swimming and diving in the shallows, collecting the abundant food, and learning to…

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Virus-driven energy theft: honeybee model

August 22, 2016
James Kohl
RNA Directed
No Comments

The Buzz about Honey Bee Viruses August 18, 2016 Similar to other co-evolving host—pathogen relationships, honey bee viruses have likely evolved mechanisms to overcome and/or evade bee immune responses. For example, several honey bee infecting Dicistroviruses (i.e., IAPV, KBV, and ABPV) encode a DvExNPGP motif at the 5′ terminus of their genomes, suggesting these honey bee-infecting viruses encode putative viral suppressors of RNAi similar to the Dicistroviruses Cricket paralysis virus and Drosophila C virus [52]. In addition, viruses may manipulate…

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Food supplement or licensed immunostimulant?

August 10, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Glucan from Food Supplement to a Licensed Drug   Excerpt: “…β-glucan possesses a significant immunostimulating activity in a wide variety of species, including earthworms, shrimp, fish, chicken, rats, rabbits, guinea pigs, sheep, pigs, cattle, and, last but not least, humans. Based on these results, it has been concluded that β-glucan represents a type of immunostimulanting molecule that is actively spanning full evolutionary spectrum. Some experiments also show that β-glucan can help even in the protection of plants. β-Glucan is therefore…

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Energy-dependent RNA methylation (4)

June 6, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Virus-driven energy theft causes the mutations that are linked to all pathology. That fact is critical to understanding everything currently known to all serious scientists about energy-dependent RNA methylation and healthy longevity. Unfortunately, here’s another attempt to put everything known about the de novo creation of genes back into the context of evolution, albeit without the typical focus on mutations and/or natural selection. Microbe Conversations with Skin Cells Produce Immunity Excerpt: It takes an extreme amount of energy to counteract…

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War Games: False Flag Terrorism

May 28, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
3 Comments

Sirius Cyantis (aka Sean Ovis) takes my claims about virus-driven energy theft and pathology outside the context of creationism.  Using his assumed name, he places them into the context of support for evolution. That’s an example of what happens on the “False Flag” Creationism FB group. In the context of combating evolution to fight disease, the war games become more interesting. Most people in False Flag groups do not know who they are fighting against. In the end it won’t…

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