autophagy

God’s microRNA-mediated Creation of genotypes (2)

September 9, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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More than 127,000 indexed published works link God’s energy-dependent Creation of microRNAs to all biodiversity via energy-dependent microRNA-mediated DNA supercoiling . See: microRNA See first: God’s microRNA-mediated Creation of genotypes (1) See also: MiR-125b regulates the differentiation of hair follicles in Fine-wool Sheep and Cashmere goats by targeting MXD4 and FGFR2 9/6/21 If you can’t link this to chromosomal rearrangements and sympatric speciation in species from flies to labradoodles, you haven’t played the STEM toy for ages 14+ “Genotype.” One…

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MicroRNA-mediated population control (7)

August 6, 2021
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Quantum coherence was linked across kingdoms to coherently organized biology in MicroRNAs organize intrinsic variation into stem cell states and via the STEM toy for ages 14+ Genotype. Every fact that links quantum coherence to coherently organized biology via the energy-dependent structural diversity of supercoiled DNA and microRNA-mediated stem cell Creation via RNA interference (#RNAi) was replaced by claims of cryptic transcription in mammals. See: Altered chromatin states drive cryptic transcription in aging mammalian stem cells 8/2/21 We show that…

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Pheromones protect us from viruses (9)

April 4, 2021
James Kohl
biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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It may be a form of insanity that prevents theorists, atheists, and Communists from addressing the facts that have been detailed in the context of: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 …a class of agents called covalent peptidomimetic inhibitors that work by using strings of unnatural amino acids to bind to specific target proteins. See for instance:  A two-amino acid change in the hemagglutinin of the 1918 influenza virus…

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The microRNA-mediated future of humanity (3)

April 24, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Nutrigenomics, Pharmacogenomics, Physics, RNA interference, What's in the News
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Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera. On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper Patient-derived mutations impact pathogenicity of SARS-CoV-2 We observed intrapersonal variation and 6 different mutations in the spike glycoprotein (S protein), including 2 different SNVs that…

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The tipping point (revisited): 100K (3)

April 3, 2020
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, RNA Directed, RNA interference
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More than 100,000 indexed published works that mention microRNAs link the Creation of anti-entropic virucial light from light-activated microRNA biogenesis to RNA-mediated autophagy via the physiology of reproduction and biophysically constrained viral latency in all living genera. See for review: The tipping point (revisited): 100K (1) at MicroRNA-mediated.pro See for review: The tipping point (revisited): 100K (2) at Autophagy.pro Moving forward to what is known about how microRNAs are linked from RNAs to healthy longevity see: Autophagy regulation by microRNAs:…

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Virus-driven downsizing of the human brain (5)

March 3, 2019
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference
One Comment

Virus-driven downsizing of the human brain (3) (8/9/16) Virus-driven downsizing of the human brain (4) (4/23/17) Who the heck is James V. Kohl? Thanks for asking. Posted by u/Sphinx_for_hire 3 months ago I’m in biochemistry/toxicology and was reading up on LUCA (aka Last Universal Common Ancestor). While Googling the work of Nick Lane, I stumbled upon the following page absolutely flaying Lane’s and others’ LUCA theories. This guy, James V. Kohl, has many websites in which he writes about human…

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The concept of a species (4)

June 12, 2018
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Subatomic
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Trump Tries to Destroy the West The alliance between the United States and Western Europe has accomplished great things. It won two world wars in the first half of the 20th century. Then it expanded to include its former enemies and went on to win the Cold War, help spread democracy and build the highest living standards the world has ever known. President Trump is trying to destroy that alliance. —– Scientific creationists from South Korea, the “creationist capitol of…

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A single base change refutes theistic evolution

May 3, 2018
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA–Mediated Epigenetic Heredity
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Everyone who failed to learn how light-activated endogenous substrates biophysically constrain viral latency is playing “catch up” to serious scientists. The serious scientists know how quantized energy-dependent RNA-mediated cell type differentiation occurs in the context of the physiology of reproduction in all living genera. Rather than accept the fact that the innate immune system of bacteria (CRISPR) linked the pheromone-controlled physiology of reproduction from autophagy to biophysically constrained viral latency, theorists decided to waste money on virus-assisted gene-editing attempts to…

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MicroRNA-mediated denuclearization (2)

April 24, 2018
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Summary: The virus-driven theft of quantized energy creates a cellular environment that promotes the survival and self-proliferation of viruses by encoding viral miRNAs or miRNA-like molecules. The viral miRNAs or miRNA-like molecules target different types of host cells. The sun’s anti-entropic virucidal energy biophysically constrains viral latency in the context of global control of human ES cell differentiation via circRNAs derived from lncRNAs. That fact refutes all neo-Darwinian gene-centric pseudoscientific nonsense. That fact also attests to the link from Chinese…

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2018 March for Science vs microRNAs (2)

April 18, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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The anti-entropic virucidal energy of sunlight on contact with water has been linked from the creation of ATP synthase to the creation of ATP and to the creation of RNA. Energy-dependent RNA-mediated DNA repair has been linked to biophysically constrained viral latency via the creation of microRNAs and feedback loops linked to the food energy-dependent microRNA-mediated physiology of reproduction. The physiology of energy-dependent pheromone-controlled reproduction biophysically constrains viral latency in the context of the creation of the innate immune system…

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