base editing

https://media.springernature.com/lw900/springer-static/image/art%3A10.1038%2Fs41467-017-02632-8/MediaObjects/41467_2017_2632_Fig6_HTML.jpg

Why Trump won’t meet with some 2017 Nobel Laureates

January 20, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Excerpt: Others have seen the latest experimental evidence on biophysically constrained energy storage coming, but they have remained relatively silent. This is a deliberate attempt to increase the number of my tweet impressions to more than 80K since Christmas eve, during the same month that ~1000 more articles on microRNA-mediated energy storage were added to the PubMed database. On June 24, 2017,  I joked about the claims of science journalist Philip Ball. His pseudoscientific nonsense about quantum common sensee led to…

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Enzyme-constrained interethnic biodiversity (6)

January 12, 2018
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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I think that I may be able to finish this series before the end of the month and use my tweets to expose more than 100,000  people to what is known about how the energy-dependent creation of microRNAs prevents all pathology. See for one example of more than 68,000 published works: MicroRNA-22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3 For an extensive review of biologically-based biophysically constrained viral latency, see: Enzyme-constrained interethnic biodiversity…

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Energy-dependent base editing and correction of mutations (3)

December 26, 2017
James Kohl
RNA Directed
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Alzheimer’s is tractable from lactose intolerance to diverticulitis and/or colon cancer, which progresses to Alzheimer’s in some people. Others ecologically adapt via a change in diet or reduction of social stress. Conclusion: Theories are the cause of all pathology. Excerpts from Energy-dependent base editing and correction of mutations (2) with a primate-specific addendum See: From Fertilization to Adult Sexual Behavior (1996) Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual…

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Two retractions of human idiocy

December 7, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Excerpt: …she was interested in the PNAS research because it identified a potential inhibitor of the hepatitis C virus… ”Definitely embarrassing:” Nobel Laureate retracts non-reproducible paper in Nature journal 1) This retraction marks the second in six months for Nature Chemistry after having none for eight years. 2) In 2009, Szostak also retracted a 2008 paper in Proceedings of the National Academy of Sciences after an outside researcher could not replicate the results. The retraction notice credited Katherine Berry, then…

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Energy-dependent base editing and correction of mutations (1)

November 27, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, RNA Directed, RNA editing, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity
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Summary: Food energy-dependent base editing has been linked to biophysically constrained viral latency via microRNA editing, RNA editing and the pheromone-controlled fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Correction of β-thalassemia mutant by base editor in human embryos Conclusion: Intriguingly, we found that HBB −28 (A>G) mutation repairing efficiency was about 20% in the constructed cell line and primary skin fibroblast cells. Although 10.7% of the repaired skin fibroblast cells were heterozygous, it is still…

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Light-activated error free DNA repair

November 14, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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Summary: The same set of microRNAs controls expression of the genes for rate-limiting enzymes, which control differences in the hormone production of different hormones in insects and crustaceans. That fact led to this claim in: The secret to safe DNA repair. …if you don’t have this enzyme, then this error-free repair is stopped. You can’t do it. If you can’t do the error-free repair, among other things that happen is that you expect these cells to be cancer prone. The…

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From base editing to RNA editing (5)

November 1, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Nutrigenomics, RNA Directed, RNA editing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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1) Maturity’ molecule helps adolescent brain grow up   2) Geneticists are starting to unravel evolution’s role in mental illness: Hints emerge that past environments could have influenced psychiatric disorders   Please try to link the maturity molecule to the evolution of mental illness outside the context of food energy-dependent base editing, RNA editing, RNA-mediated amino acid substitutions and the pheromone-controlled physiology of reproduction that stabilizes the organized genomes of all living genera via chromosomal rearrangements.   Then see:Oppositional COMT…

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From base editing to RNA editing (4)

November 1, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: To claim evolution, Koonin must link food energy from the pheromone-controlled physiology of reproduction to fixation of a beneficial mutation in the organized genome of one species that evolved into another species. Search Results for “base editing” = 82 blog posts starting with Cell-type differentiation on February 7, 2014 Search Results for “RNA editing” = 95 blog posts starting with In theory, or supported by experimental evidence? October 22, 2014 See for comparison PubMed: “base editing” (33 citations) and…

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From base editing to RNA editing (3)

October 31, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Claims about spontaneous deamination fail to link energy-dependent changes from base editing to RNA-mediated DNA repair of damage caused by the virus-driven degradation of messenger RNA. Highly efficient RNA-guided base editing in mouse embryos 27 February 2017 They reported the use of RNA-programmable deaminases to make various animal models with single amino-acid substitutions.They linked the single amino acid substitutions from the correction of nonsense mutations in the future to the correction of genetic defects in human embryos. Reported as:…

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