base pair changes

Methylation and the innate immune system (2)

Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions These results highlight the high intrinsic specificity of TMD interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of TMD interactions and the activity of transmembrane proteins. RNA-directed DNA methylation is energy-dependent. The “minimal chemical difference” is linked from the quantized energy of virucidal light to all biophysically constrained biodiversity via base pair changes, single…

Read More

From E. coli to monkeys and mankind: Theories vs models (2)

Dedicated to Dr. Tom Jordan and Priscilla Jordan on the day of their retirement from the Baptist ministry, May 28, 2017. They always encouraged me to learn more about the “Laws of Biology” and link the Laws from energy as information to all biodiversity on Earth via the physiology of reproduction. See also: From E. coli to monkeys and mankind: Theories vs models High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding (5/23/127) …changes in observed association…

Read More

Nutrient-dependent autophagy

Autophagy: cellular and molecular mechanisms Excerpt: Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. My comment: Autophagy is energy-dependent See for example: Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency…

Read More

Neuroplasticity

Can You Think Yourself Into a Different Person? Excerpt 1) Those who over-evangelise emerging disciplines like neuroplasticity or epigenetics can sometimes be guilty of talking as if the influence of our genes no longer matters. Excerpt 2) Of course, it’s our malleable brains that have moulded themselves to these rhythms. See also: Nature and nurture: Human brains evolved to be more responsive to environmental influences See for comparison: Mae-Wan Ho: No Boundary Really Between Genetic and Epigenetic My comment: Everything…

Read More

Receptor methylation controls behavior

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Excerpt 1) The addition of a methyl group to an arginine residue can remove a hydrogen bond donor and decrease the electrostatic surface potential at the residue, resulting in a change in size and hydrophobicity that can affect its interaction with binding partners (21). Excerpt 2) Together, these results led us to propose that arginine methylation promotes D2-like dopamine receptor signaling and that this mechanism of receptor regulation is conserved…

Read More