BDNF Val66Met

Epigenetic inheritance of spatiotemporal regulation (3)

Summary: Wen Zhou’s group has linked the creation of anti-entropic virucidal light from the quantized energy-dependent creation of microRNAs to the food energy-dependent neuroendocrine origins of human behavior via the pheromone-controlled physiology of reproduction and fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Simply put, she has linked quantum physics to quantum souls via what is known about biophysically constrained viral latency in the context of the cell biology game Cytosis and the future of biology.…

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Epigenetic inheritance of spatiotemporal regulation (2)

See: Epigenetic inheritance of spatiotemporal regulation Summary: Food energy-dependent changes in base pairs have repeatedly been linked to spatiotemporal regulation of mRNA translation via the pheromone-controlled physiology of reproduction and microRNA-mediated amino acid substitutions that stabilize organized genomes. See:  Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes One SNP rs4713668 (P=4.62 × 10−4) identified in our study, was in LD (r2=0.65) with rs3227, which is one of the three variants recently…

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New Testament Book Cover Refutes Theistic Evolution

Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

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Epigenetic effects of stress by Bruce McEwen (2)

Summary: …rapid mRNA turnover starts with the energy-dependent de novo creation of microRNAs and ends with the virus-driven degradation of messenger RNA, which links mutations to all pathology.   This was reported in the following context: “RNA molecules live short lives” July 12, 2017 See also: Epigenetic effects of stress by Bruce McEwen (1) Summary: In the early 1990’s, Bruce McEwen inspired my life’s works, which link the epigenetic effects of nutrient-stress and/or social stress to the fact that RNA biosynthesis…

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Energy-dependent epigenetic translation to mRNA stability (3)

Energy-dependent epigenetic translation to mRNA stability (2) Energy-dependent epigenetic translation to mRNA stability (2) See for comparison this treatise on climate change packaged as information on the evolution of a flying snake. Fossil ‘winged serpent’ is a new species of ancient snake At the time that Zilantophis dwelled there, the site was a sinkhole surrounded by forest, attracting a variety of animals. The local fauna included ancient representatives of familiar North American creatures such as bears, beavers and salamanders. Others…

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Energy-dependent alternative splicings 1996 – 2016 (2)

See also: Energy-dependent alternative splicings 1996 – 2016 Re: Rs3827760 is Val370Ala and EDARV370A No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology. For example, see: Genome recoding by tRNA modifications The succession of mRNA codons controls the synthesis of polypeptides through the complementarity between each of the 64 possible codon triplets and the tRNA anticodons that decode…

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RNA methylation, behavior, and disease

Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016)   My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must be linked to genetic networks via the energy-dependent innate immune system. That’s how all serious scientists knew they would need to link angstroms to ecosystems…

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Stress-induced energy-dependent DNA repair

Predicting 3D Structure, Flexibility, and Stability of RNA Hairpins in Monovalent and Divalent Ion Solutions Abstract excerpt:  A full understanding of RNA-mediated biology would require the knowledge of three-dimensional (3D) structures, structural flexibility, and stability of RNAs. My comment: The stability of RNAs is nutrient energy-dependent. Nutrient-dependent microRNAs and adhesion proteins link RNA-mediated amino acid substitutions in the histones of supercoiled DNA to protection from virus-driven entropy in all living genera.  Energy does not “emerge” and energy stress does not…

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Genes, orchid odors, and pheromones from blonds

1) The Genetics of Blond Hair (2014) and 2) Orchids give off human ‘body odor’ to attract mosquitoes (2016) Both articles link RNA-mediated cell type differentiation in all invertebrates and all vertebrates to every aspect of cell type differentiation in plants. …studies of genetic variation in thousands of people have linked at least eight DNA regions to blondness based on the fact that a certain DNA letter, or base, was found in people with that hair color but not in…

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Amino acid substitutions, stress, and human behavior

Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity Excerpt: …33% of the human population present a BDNF Val66Met SNP that leads to a valine-to-methionine substitution in the BDNF protein at codon 66, and this SNP has been associated with increased susceptibility to development of stress-related disorders (21, 22). Reported as: Newly discovered windows of brain plasticity may help with treatment of stress-related disorders Excerpt: The researchers also identified the molecule regulating…

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