beneficial mutations

Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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Antithetical conclusions (5)

Something is antithetical when it is in complete and utter opposition to the character of something. For example, see: Small population size? It doesn’t have to mean that species can’t adapt to environmental change. A new study shows that small populations of species can still adapt and respond to natural selection. Natural selection for energy-dependent codon usage in the context of the physiology of reproduction is the only way known to serious scientists for a species to ecologically adapt. Theorists…

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Energy-dependent biodiversity (2)

This will be my next post to the “Creationism” FB group, where biologically uninformed antagonists have been attacking me on all my other posts or my comments on the posts of others. See, for example: In a series of four presentations during three online conferences: “Neuroscience” “Molecular Diagnostics” “Genetics and Genomics,” I linked Einstein’s math and physics, from Schrodinger’s claims about anti-entropic energy to Dobzhansky’s claims about amino acid substitutions and cell type differentiation in many different species… Currently, more…

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Creating and/or programming the immune system

A programming language for living cells Thanks to Fabricio Paes de Medeiros for calling attention to this example of an engineered innate immune system. The immune system links the epigenetic landscape to the physical landscape of supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. Excerpt: The sensors can detect different compounds, such as oxygen or glucose, as well as light, temperature, acidity, and other environmental conditions. My comment: It will be interesting to see…

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A two-faced protein enables RNA-mediated DNA repair (3)

See: A two-faced protein enables RNA-mediated DNA repair (2) See: A two-faced protein enables RNA-mediated DNA repair My comment: Attempts to place what is currently known about the links from atoms to ecosystems back into the context of neo-Darwinian pseudoscientific nonsense have been doomed to fail ever since Dobzhansky (1973) wrote: Nothing in Biology Makes Any Sense Except in the Light of Evolution. He linked nutrient-dependent amino acid substitutions to cell type differentiation across species and also claimed “…the so-called…

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RNA-mediated development

The Arthur M. Sackler Colloquia are sources for up-to-date information about biologically based cause and effect, which links epigenetic effects on hormones to the affects of hormones on behavior. The difference between effect and affect was place into the context here: Correction for McEwen, Brain on stress: How the social environment gets under the skin The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.” In the early 1990’s, Bruce McEwen…

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Creating and maintaining the human virome

Comprehensive serological profiling of human populations using a synthetic human virome Excerpt from the editor’s summary: Despite differences in the rates of exposure to specific viruses, the antibody responses in most individuals targeted the same viral epitopes. My comment: Received: Fri, 05 Jun 2015 14:19:20 -0400 From an even broader perspective, this may be a step forward towards linking viruses and viral microRNAs to entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent microRNAs to cell type differentiation via the…

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Environment epigenetically shapes the immune system

Environment, more than genetics, shapes immune system 1) –with my emphasis Re: “There’s nothing here that is revolutionary or requires rethinking of our assumptions about how the immune system functions…” My comment: They removed assumptions about cell type differentiation by linking differences in metabolic networks to genetic networks. They indirectly showed that ecological adaptations are nutrient-dependent and the adaptations are controlled by the metabolism of nutrients to species-specific pheromones. The pheromones control the nutrient-dependent physiology of reproduction in species from…

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