beneficial mutations

MicroRNA-mediated population control (6)

7/29/21 I linked fixation of one amino acid substitution, EDAR V370A from the diet of human populations in East and central China to the New World during the past 5-10K years of ecological adaptations via https://nature.com/news/past-5-000-years-prolific-for-changes-to-human-genome-1.11912 WHO still hates me for doing that. How? “The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.” Clearly, there has never been support for stupid theories about the emergence…

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MicroRNA-mediated population control (5)

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 and Visualization and characterization of RNA–protein interactions in living cells 7/27/21 cannot be linked to stupid theories about the automagical emergence of energy from the cosmic void or theories that link beneficial mutations during the past billions to millions of years to our evolution from pond scum or light-activated carbon fixation in cyanobacteria. For contrast, the visualizations support this claim: “Post-transcriptional modifications, especially phosphorylation play crucial roles in regulation of…

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Quantum Darwinism (3)

“Quantum biology” is quantum Darwinism Starting from…discovery of quantum coherence in low-temperature photosynthetic microbes in 2007, quantum coherence is emerging as a general principle of biological systems. See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. Theorists chose neo-Darwinian pseudoscientific nonsense about beneficial mutations and evolution via natural selection across billions to millions of years instead of the explanatory power of quantum Darwinism. Their ignorance…

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Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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Antithetical conclusions (5)

Something is antithetical when it is in complete and utter opposition to the character of something. For example, see: Small population size? It doesn’t have to mean that species can’t adapt to environmental change. A new study shows that small populations of species can still adapt and respond to natural selection. Natural selection for energy-dependent codon usage in the context of the physiology of reproduction is the only way known to serious scientists for a species to ecologically adapt. Theorists…

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Energy-dependent biodiversity (2)

This will be my next post to the “Creationism” FB group, where biologically uninformed antagonists have been attacking me on all my other posts or my comments on the posts of others. See, for example: In a series of four presentations during three online conferences: “Neuroscience” “Molecular Diagnostics” “Genetics and Genomics,” I linked Einstein’s math and physics, from Schrodinger’s claims about anti-entropic energy to Dobzhansky’s claims about amino acid substitutions and cell type differentiation in many different species… Currently, more…

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Creating and/or programming the immune system

A programming language for living cells Thanks to Fabricio Paes de Medeiros for calling attention to this example of an engineered innate immune system. The immune system links the epigenetic landscape to the physical landscape of supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. Excerpt: The sensors can detect different compounds, such as oxygen or glucose, as well as light, temperature, acidity, and other environmental conditions. My comment: It will be interesting to see…

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A two-faced protein enables RNA-mediated DNA repair (3)

See: A two-faced protein enables RNA-mediated DNA repair (2) See: A two-faced protein enables RNA-mediated DNA repair My comment: Attempts to place what is currently known about the links from atoms to ecosystems back into the context of neo-Darwinian pseudoscientific nonsense have been doomed to fail ever since Dobzhansky (1973) wrote: Nothing in Biology Makes Any Sense Except in the Light of Evolution. He linked nutrient-dependent amino acid substitutions to cell type differentiation across species and also claimed “…the so-called…

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RNA-mediated development

The Arthur M. Sackler Colloquia are sources for up-to-date information about biologically based cause and effect, which links epigenetic effects on hormones to the affects of hormones on behavior. The difference between effect and affect was place into the context here: Correction for McEwen, Brain on stress: How the social environment gets under the skin The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.” In the early 1990’s, Bruce McEwen…

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Creating and maintaining the human virome

Comprehensive serological profiling of human populations using a synthetic human virome Excerpt from the editor’s summary: Despite differences in the rates of exposure to specific viruses, the antibody responses in most individuals targeted the same viral epitopes. My comment: Received: Fri, 05 Jun 2015 14:19:20 -0400 From an even broader perspective, this may be a step forward towards linking viruses and viral microRNAs to entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent microRNAs to cell type differentiation via the…

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