biodiversity

Hypothesis free pseudoscience vs facts (5)

See first: Hypothesis free pseudoscience vs facts (4) Re: There is literally nothing left of neo-Darwinian pseudoscientific nonsense, and yet pseudoscientists still make the same ridiculous claims. See for comparison:  Current Drug Design Studies for Hsp70 in Oncological Applications SBD [substrate binding domain] contains hydrophobic amino acid residues, and this hydrophobic cavity helps unfolded substrate proteins to fold their native structure. Thus, exposed part of the folded proteins may not interact with each other and cause aggregation [in the context…

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Hypothesis free pseudoscience vs facts (4)

See first Hypothesis free pseudoscience vs facts (3) See also: The terrorist inside my husband’s brain Conclusion: I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen. If only…

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Chromatin: The structure of DNA (3)

See:  Chromatin: The structure of DNA (2) Inherited parental methylation shifts over time, may have functional effects in the brain and other tissues Excerpt: …researchers have theorized that inherited methylation, also referred to as parental imprinting, largely remains stable throughout development, except during two important developmental milestones: after fertilization and during the creation of sperm and egg cells. Altered gene imprinting at other times has been associated with developmental disorders and cancer. My comment: Theorists have historically failed to learn…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Protecting 4 billion people from virus-driven entropy

New England Biolabs® Announces 2016 Passion in Science Awards® Recipients Congratulations to Scott O’Neill for helping to protect the health of billions of people from virus-driven energy theft and genomic entropy by infecting mosquitoes with viruses before they can spread virus-caused pathology. Content is covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc.  However, its use may require you to obtain additional third party intellectual property rights for certain applications. See also: Chris…

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Co-evolution and co-speciation replace neo-Darwinian nonsense

Tree-rings reveal secret clocks that could reset key dates across the ancient world It is perhaps easy to forget that we have co-evolved on this planet with micro-organisms, including bacteria, which may be either beneficial or harmful to us. Similarly, viruses cannot copy themselves without help from our cells. Without us, they simply wouldn’t exist. Watch as science journalists change evolution to co-evolution and biodiversity is portrayed as co-speciation. Theorists who missed the paradigm shift continue their desperate attempts to…

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Energy-dependent natural fluorescence and bioluminescence

Researchers discover that DNA naturally fluoresces Everybody has overlooked this effect because nobody asked the right question,” said Backman…. “It sounds cliché, but you get the answer to the question you ask. When we actually asked the right question, we got a very different answer than expected. Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Researchers did not ask any questions about how the energy-dependent weekend resurrection of the bacterial flagellum occurred in an organism that…

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Biophotonics, glycobiology, quantized biodiversity (3)

Biophotonics, glycobiology, quantized biodiversity Biophotonics, glycobiology, quantized biodiversity (2) Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability Excerpt: We therefore propose a model whereby, similar to neurons, astrocytes respond directly to a plethora of nutrient and endocrine signals and, in turn, contribute to adjusting CNS control of systemic metabolism according to nutrient availability. My comment: They reassert the fact that my model is the only model of nutrient-dependent pheromone-controlled ecological adaptation, and finally also dismiss the pseudoscientific nonsense…

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Biophysically constrained cell type differentiation

Intrinsic limits to gene regulation by global crosstalk Excerpt: A paradigmatic example is that of the aminoacyl transfer RNA synthetase1, which uses kinetic proofreading2 to load appropriate amino acids onto matching tRNAs. This and other examples—including DNA replication, ligand sensing3, protein–protein interactions4,5,6,7,8,9, recognition events in the immune system10,11 and molecular self-assembly12—indicate that biology places a large premium on the reduction of unintended ‘crosstalk’, a generic term that encompasses all potentially disruptive processes due to reactions between non-cognate substrates. Reported as:…

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Biophotonics, glycobiology, quantized biodiversity (2)

From Fertilization to Adult Sexual Behavior (1996) In our section on Molecular epigenetics, we wrote: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility…

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