biodiversity

Energy-dependent physical and biophysical constraints (1)

Summary: The hitchhiking, the epistasis, and the dynamics of adapting populations are energy-dependent and biophysically constrained in the context of RNA-mediated protein folding chemistry. The virus-driven degradation of messenger RNA links mutations to all pathology in all living genera. An upper limit on the functional fraction of the human genome For the human population to maintain a constant size from generation to generation, an increase in fertility must compensate for the reduction in the mean fitness of the population caused,…

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Epigenetic effects of stress by Bruce McEwen (2)

Summary: …rapid mRNA turnover starts with the energy-dependent de novo creation of microRNAs and ends with the virus-driven degradation of messenger RNA, which links mutations to all pathology.   This was reported in the following context: “RNA molecules live short lives” July 12, 2017 See also: Epigenetic effects of stress by Bruce McEwen (1) Summary: In the early 1990’s, Bruce McEwen inspired my life’s works, which link the epigenetic effects of nutrient-stress and/or social stress to the fact that RNA biosynthesis…

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The emergence of light as energy from a life-giving star

The Sun – our steady, reliable companion – tells a very different story up close “…a mesmerising, perspective-shaking glimpse at Earth’s life-giving star.” (video) Questions: 1) Did the energy in this life-giving star create itself? 2) How is hydrogen-atom transfer in DNA base pairs in solution biophysically constrained. 3) Who created the feedback loops that link the solar analemma from the time-space continuum to representations of biophysically constrained life and free will in the Mobius strip. 4) Was Linda Buck…

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MicroRNAs GnRH and the failure of sex research

Summary: “The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression” accurately represents what is known about food energy-dependent RNA-mediated cell type differentiation in species from soil microbes to humans. MicroRNAs are not new players in the hypothalamic control of fertility and the effects of food odors and pheromones on microRNAs link energy-dependent changes in hormones to behavior. That fact was detailed two decades ago in our Hormones and Behavior review. Now see: [MicroRNAs: new players…

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Hard Science vs the neo-Darwinian “magic box”

Summary: Identical nucleotide sequences link energy-dependent changes in binding sites to different amino acids in different proteins. The binding sites are conserved in the orthologous mammalian genes. The in vivo structure of biological membranes and evidence for lipid domains Scientists investigate how the sense of smell works in bacteria Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits As presciently predicted in the works of Richard Feynman and Bruce McEwen, bacteria feed on something that allows them to…

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Infections and age change the odor of wine and people

Summary: Food energy is a direct link from electron spin via changes, which link the sense of smell in bacteria from changes in angstroms to ecosystems in all living genera. Fruity with a note of fungus: How fungal infections change the aroma of wine …while bunch rot actually led to more positive aroma ratings due to the increased levels of fruity- and vanilla-like notes, powdery mildew decreased the level of pleasant notes in the wine, so that it received more negative…

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Energy-dependent epigenetic translation to mRNA stability (5)

Energy-dependent epigenetic translation to mRNA stability (4) From Fertilization to Adult Sexual Behavior Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. See also: The Supraspliceosome – A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus Abstract conclusion: …changes in these regulatory processing activities are associated with human disease and cancer. These findings emphasize the supraspliceosome as…

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Draining the academic swamp of parasites

National Academies Revise Conflict of Interest Policy The proposed changes follow revelations in recent years that committee members preparing reports for the Academies did not disclose industry relationships. By Ashley P. Taylor | May 3, 2017 Excerpt: They are also thinking about including not only current activities and relationships, as they do now, but past ones when determining whether or not a committee member has a COI. See for comparison: Ian Hodder: Çatalhöyük, Religion & Templeton’s 25% My comment: Past…

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Dispensing with all pseudoscientific nonsense about evolution (1)

No experimental evidence of biophysically constrained biologically-based cause and effect supports claims that the mammalian placenta “evolved.” All experimental evidence of biophysically constrained biologically-based cause and effect supports claims that the mammalian placenta is an energy-dependent pheromone-controlled ecological adaptation. See also: Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory Chemoautotrophic symbiosis is nutrient energy-dependent and pheromone-controlled. Nothing about life involves autotrophy. Everything known to serious scientists links chirality to autophagy, which protects the…

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Synthetic RNA-based switches

Synthetic RNA-based switches for mammalian gene expression control Current Opinion in Biotechnology, Volume 48, December 2017, Pages 54–60 If you wait until December, 2017 to see this article in print, you will probably be among the last of those to have missed a two decades-old paradigm shift. The fact that these researchers created synthetic RNA-based switches attests to the fact that natural selection for energy-dependent codon optimality links what organisms eat to energy-dependent RNA-mediated amino acid substitutions. The substitutions help…

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