Biology

Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

Read More

Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

Read More

Innate immunity and multiplexing

Scientists Hope to Cultivate an Immune System for Crops by Carl Zimmer Excerpt: The complex microbial world in the soil may protect plants much like our immune system protects our bodies. My comment: The speed of light on contact with water links the sun’s quantized anti-antropic virucidal energy from the de novo creation of nucleic acid precursors to biophysically constrained RNA-mediated protein folding chemistry and supercoiled DNA, which protects all living genera from virus-driven energy theft and genomic entropy. See…

Read More

The Mind’s Eyes (revisited)

Author’s copy: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences (2007) Abstract: The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self.  Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response.  The organization and activation of this neuroendocrine response modulates the concurrent maturation of the mammalian neuroendocrine system, the reproductive system, and the central nervous system during the development of sexual preferences that…

Read More

Creating gravity, nucleic acids, receptors, and supercoiled DNA

Liveblog: Scientists to announce major gravitational wave finding My comment: If they link gravitational waves and changes in the speed of light on contact with water, they will be one less step away from linking the creation of gravity to the creation of nucleic acids and the de novo creation of olfactory receptor genes and supercoiled DNA that protects organized genomes from virus-driven entropy. A new method furthers understanding of evolutionary genetics Excerpt: Since Darwin, evolutionary biologists have been fascinated…

Read More

Hydrogen-Atom Transfer in DNA Base Pairs (4)

Historical perspective: Behold James Vaughn Kohl. Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction. These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people…

Read More

The Sherlock lab: Beneficial mutations

After he challenged me in a discussion of two works on tardigrades, Gavin Sherlock‘s comments were removed from the facebook page of Serafim Batzoglou. In the context of The genome of the tardigrade Hypsibius dujardini and Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade, it quickly became clear that Gavin Sherlock knows nothing about how cell type differentiation occurs. Sherlock is the senior author of Quantitative evolutionary dynamics using high-resolution lineage tracking Excerpt: Our results…

Read More

Receptor methylation controls behavior

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Excerpt 1) The addition of a methyl group to an arginine residue can remove a hydrogen bond donor and decrease the electrostatic surface potential at the residue, resulting in a change in size and hydrophobicity that can affect its interaction with binding partners (21). Excerpt 2) Together, these results led us to propose that arginine methylation promotes D2-like dopamine receptor signaling and that this mechanism of receptor regulation is conserved…

Read More

Nucleic acids: Stability of DNA/RNA

See also: RNA-mediated events and the “theory of everything.” Freeze-thaw cycles and nucleic acid stability: what’s safe for your samples? Conclusion: …you probably need to put a handful of your representative samples to the test in the context of your particular assay, to know what’s an acceptable number of freeze-thaw cycles for your purpose. My comment: Theoretical physicists and evolutionary theorists share a purpose. Their purpose is antithetical to accurate representations of what is known about the biologically-based stability of…

Read More

Creating genes and species

The Octopus Genome: Not “Alien” but Still a Big Problem for Darwinism by Casey Luskin, August 24, 2015 Excerpt: Whenever you see “de novo” origin of a gene invoked, you know that evolutionary biologists lack any explanation for how that gene arose. My comment: I tend to use the experience-dependent “de novo” creation of olfactory receptor genes as an example of how RNA-mediated events link physics, chemistry, and biology from atoms to ecosystems via the conserved molecular mechanisms of biophysically…

Read More