Biology

A model of MHC 'evolution'

Sexual selection and the evolutionary dynamics of the major histocompatibility complex Excerpt: “Here, we present the results of the first model of MHC evolution incorporating both survival and reproduction, modelling the combined effects of natural selection and MHC-based disassortative mating on patterns of MHC allelic diversity.” My comment: Results from their first mathematical model can be compared to representations of biologically-based cause and effect in the context of our model. See From Fertilization to Adult Sexual Behavior. We linked RNA-mediated…

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RNA-mediated genetic engineering (Part 3)

RCas9: A programmable RNA editing tool Excerpt: “The researchers envision a wide range of potential applications for RCas9. For example, an RCas9 tethered to a protein translation initiation factor and targeted to a specific mRNA could essentially act as a designer translation factor to “up-” or “down-” regulate protein synthesis from that mRNA.” My comment: This “up-” or “down-” regulation of protein synthesis from mRNA occurs naturally in the context of RNA-mediated genetic engineering. Nutrient uptake alters the microRNA/messenger RNA…

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RNA-mediated genetic engineering (Part 2)

WATCH: Bill Nye the Science Guy predicts end of creationism is nigh Excerpt: “Best known as Bill Nye the Science Guy, the 58-year-old educator, TV personality and author lamented the lingering myth that the universe is a product of divine creation.” My comment: Evolutionary theorists have not described a biologically-based evolutionary event that links one species to the evolution of another. The myth of evolution was exposed via the fact that Richard Lenski’s bacteria and Michael Desai’s yeasts did not…

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Soft atheism: a case for Creation

The Case for ‘Soft Atheism’ By GARY GUTTING   Excerpt: “…much as I admire Dawkins’s work in evolutionary biology and in enhancing the public understanding of science…” My comment: The case against evolution. Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes Biophysical constraints that enable the intermolecular tethering of RNA to DNA also link the epigenetic landscape to the physical landscape of DNA via the conserved molecular mechanisms of RNA-mediated events in species from…

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Darwinian theories vs Darwin's facts

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated natural selection in the video. For comparison, tenOever on microRNA and Vaccines  addresses what is currently known about glucose-dependent RNA-mediated amino acid substitutions and self vs non-self identification in viruses to living species with varying degrees of nutrient-dependent pheromone-controlled ecologically-adapted organismal complexity.…

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