biophysically constrained

Controlled amino acid treatment of all pathology

Amino acid studies.com Excerpt: One of the cancer treatments that seems to be proving effective over time is CAAT: Controlled Amino Acid Treatment. CAAT works by restricting certain amino acids from the diet to combat the growth and reproduction of the cancerous cells. Excerpt: doctors can now actively battle cancers, using the best weapons possible, natural amino acids, which are actually designed to make changes in the body. The trick has been to understand which changes are beneficial to cancer…

Read More

Energy-dependent purifying selection / autophagy (2)

See: Energy-dependent purifying selection / autophagy Thanks to Teresa Binstock for alerting me to this example, which was reported as: Shared epigenetic changes underlie different types of autism. Teresa wrote: “You might enjoy a glance at a use of epigenetic technology. Findings begin to answer, why such syndrome-defining traits given such diverse inter-individual genetics and numerous associations with environmental factors.” She co-authored our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior. She took responsibility for the accurate…

Read More

Energy-dependent purifying selection / autophagy (3)

See also: Energy-dependent purifying selection / autophagy (2) But see: Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters Re: “…the interactomes of 31,253 annotated promoters in 17 human primary blood cell types.” Excerpt: Here, we link thousands of GWAS SNPs to their putative target genes and prioritize more than 2,500 potential disease-associated genes, three-quarters of which were not previously implicated. Reported as: Researchers identify missing links that connect human DNA variation with disease My comment:…

Read More

Energy-dependent purifying selection / autophagy (6)

See: Energy-dependent purifying selection / autophagy (5) Simply put all aspects of biophysically constrained energy-dependent cell type differentiation must first be linked from the physiology of reproduction to ecological adaptations, or they must be linked from energy theft to the evolution of pathology. See for contrast and comparsion: Finding your diagnosis in the brave new world of genetics-based medicine by John Hewitt Excerpts: Typically all they have is a stack of diffuse paper reports and xeroxed publications from the primary…

Read More

Optogenetics: Let there be virucidal light!

NIH Awards $1.4M Grant to Support Optogenetics Research Excerpt: Synaptic plasticity, learning and memory are regulated by protein signaling in the brain. Many forms of learning disabilities and other mental diseases may be caused by abnormal protein signaling. To address these brain disorders and diseases, it is crucial to understand on a molecular level the underlying processes within the brain that are involved in learning and memory.” My comment: When someone like Anna Di Cosmo, John Hewitt or Bruce McEwen…

Read More

Base pairs, amino acids and phenotypes

Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. Autophagy is the established link from energy-dependent changes in base pairs and RNA-mediated amino acid substitutions to DNA repair in the context of polycombic ecological adaptations that prevent the hecatombic evolution of virus-driven pathology. Inventing new detailed models of DNA repair serves only to confuse those who have already…

Read More

Building delicious base pairs in class. It’s elementary Watson and Crick

 Candy DNA https://1.bp.blogspot.com/-72XtdR9SrgE/WC6D1cZx_TI/AAAAAAAAecg/bIVDL6mH4jE_HEJ8kxg16mzQj97tH5mkQCLcB/w400-h247-p/candy-chromosomes-Clinical-Laboratory-Blogspot-com.jpg Building delicious A- T and G – C pairs This might be the best way to show students that base pair changes are nutrient energy-dependent and biophysically constrained by autophagy in the context of the physiology of reproduction, which links them to chromosomes as the units of transgenerational epigenetic inheritance. For example, the educator could start by telling them that if the base pair changes were not biophysically constrained by the chemistry of RNA-mediated protein folding, the…

Read More

Energy-dependent maternal-to-zygotic transition

Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications ON 11/14/16 The co-author Mohamed Samir wrote:  Because our article is among the top 25% most viewed and downloaded articles in the third quarter of 2016 in “Frontiers in Veterinary Science”, The editor of the journal has invited me to host and moderate a new research topic in his journal about miRNAs in veterinary filed. Thanks God. The topic is virtually guaranteed to bring out the…

Read More

Epigenetically effected energy-dependent fluorescence

See also: Energy-dependent natural florescence and bioluminescence Membrane vesicles in sea water: heterogeneous DNA content and implications for viral abundance estimates Published online November 8, 2016, which was day two of a conference held in an attempt to revise neo-Darwinian pseudoscientific nonsense, and also the second day that this block site was disabled. Abstract excerpt: “…DNA is packaged heterogeneously within vesicle populations, and it appears that vesicles are likely to be a minor component of SYBR-visible particles in natural sea…

Read More

Epigenetics and autophagy vs mutations and evolution (5)

Two-Photon Microscopy’s Historic Influence on Neuroscience Excerpt: Yuste says he’s proud of what he and Denk accomplished. “But now I go to meetings where everyone is presenting two-photon calcium imaging, and no one knows, or remembers, or cites our work,” he says, laughing. My comment: What else can be done but laugh? Most researchers still have not linked the anti-entropic energy of virucidal ultraviolet light from the biophysically constrained RNA-mediated chemistry of protein folding to all biodiversity in all genera…

Read More