biophysically constrained

Epigenetics and autophagy vs mutations and evolution (4)

“Tobacco mosaic virus (TMV) is a positive-sense single stranded RNA virus that infects a wide range of plants, especially tobacco and other members of the family Solanaceae. The infection causes characteristic patterns, such as “mosaic”-like mottling and discoloration on the leaves (hence the name). TMV was the first virus ever to be discovered. Although it was known from the late 19th century that an infectious disease was damaging tobacco crops, it was not until 1930 that the infectious agent was…

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Epigenetics and autophagy vs mutations and evolution

RNA interfernce in “evolution” My comment: What evolved? See for comparison: Energy-dependent RNA-mediated biophysically constrained protein folding chemistry in the context of ecological adaptation.  

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From Precis to Proof in 6000 years

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

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Coulombic interactions facilitate polycombic adaptation

RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly Summary: Everything known to serious scientists about energy-dependent biophysically constrained RNA-mediated protein folding chemistry is attributed to “Nature” and evolution with no consideration for where the energy came from or where it goes when viruses use it for their replication. See also: War Games: False Flag Terrorism (2) I baited Sean Ovis, and caused him to join a discussion on “The Battlefield.“Sean Ovis regurgitated parts of my…

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Top-down adaptation vs bottom-up evolution

Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors Excerpt: Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically alter the balance of life in the oceans, ripping away huge…

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Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)

See: Light ‘drives’ adaptation; nothing ‘drives’ evolution See also: Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors Excerpt (from 1996):  Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically…

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Virus-mediated hecatombic evolution

Virus-mediated archaeal hecatomb in the deep seafloor These findings provide new evidence for a possible link between viral infections and chemoautotrophic production in the microbial food web. My comment: I hereby stake my claim to the invention of the term”hecatombic evolution.” At the forthcoming meeting of the Royal Society next month, I expect full consideration to be given to use of “hecatombic evolution” to replace neo-Darwinian evolution and/or the “Modern Synthesis” or mutation-driven evolution until everyone in the world realizes…

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Nutrient-dependent autophagy

Autophagy: cellular and molecular mechanisms Excerpt: Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. My comment: Autophagy is energy-dependent See for example: Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency…

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Life is energy-dependent task management

See also: Life is energy-dependent task management (2) Press Release: The Nobel Prize in Chemistry 2016  for the design and synthesis of molecular machines Excerpt: They have developed molecules with controllable movements, which can perform a task when energy is added. My comment: When energy is added is the key to understanding healthy longevity in the context of popular information Popular information (link opens pdf) Excerpt: All chemical systems strive for equilibrium – a lower energy state – but this…

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Hypothesis free pseudoscience vs facts (4)

See first Hypothesis free pseudoscience vs facts (3) See also: The terrorist inside my husband’s brain Conclusion: I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen. If only…

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