biophysically constrained

From gut bacteria to breast milk and back

Breast milk may alter behaviour of babies Milk contains sugars designed to feed gut bacteria that affect brain Excerpt:  Breast milk contains a lot of sugars that infants can’t digest, but that feed bacteria that live in human intestines. Those bacteria don’t just help digest food, said Hinde. “They can release chemical signals that travel to the infant’s brain and shape neurodevelopment.” Studies in mice and rats show that signals released by bacteria in the gut can affect how sociable and…

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Misunderstanding cancer

Tumor-Only Genetic Sequencing May Misguide Cancer Treatment in Nearly Half of All Patients, Study Shows Excerpt 1) “…they counted 382 possible tumor-related changes. But after comparing a patient’s full germline genome to his or her tumor genomes, they determined that, on average, 249 of these changes were part of the patient’s normal, inherited genetic variation and were not tumor-specific.” Excerpt 2) “In addition to selecting personalized therapies for patients with cancer, sequencing the normal tissue genome can also increase the…

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Graphic misrepresentations of ecological adaptation

This infographic breaks down the top five misconceptions about evolution Excerpt: “Share with all your creationist friends”. Excerpt: “This definition is the best description to date that captures the ever-changing living world.” “[W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et al. did was invent…. Evolution was defined as “changes in gene frequencies in natural populations.” The accumulation of genetic mutations was touted to be enough to change one species to another…. Assumptions, made but not verified, were taught as fact.”…

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Creating nothing but a theory (2)

Seeing the (UV) light: Previously undetected difference in human mutation rate unique to Europeans Excerpts from the discussion: Q: What’s the threshold at which UV-induced substitutions become UV-induced mutations? A: The balance of viral microRNAs to nutrient-dependent microRNAs is the determinant of controlled vs perturbed cell type differentiation in all cells of all individuals of all genera. Cell type differentiation is biophysically constrained by the nutrient-dependent chemistry of RNA-mediated protein folding, which is perturbed by mutations. That’s why uncontrolled mutations…

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Virus-driven origin of life

On the Origins of Life A new experimental system demonstrates that precursors of ribonucleotides, amino acids, and lipids may have simultaneously arisen from the same prebiotic chemistry. By Jef Akst | March 17, 2015 “This is a very important paper,” Jack Szostak, a molecular biologist and origin-of-life researcher… See also: Luis P. Villarreal: We Need a Nonlinear Language for Life Nobelist Jack Szostak has told me this about autocatalytic sets: the people who came up with the original idea, like…

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Luis P. Villarreal tells it like it is

Luis P. Villarreal has led the way towards discovery of the “origins of life.” He has helped to elucidate what is currently known about how the epigenetic landscape becomes the physical landscape of DNA in the organized genomes of species from microbes to humans. Kudos to Suzan Mazur for admitting that she missed learning about his works. Perhaps a few neo-Darwinian evolutionary theorists will also admit they have missed something very important about the role of viruses in cell type…

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Walk towards the light

Cockroaches Accumulate Light to See in the Dark Excerpt: “Taking into account the size of the experiment’s stripes, the optical properties of the roaches’ eyes and the amount of photons available, the team concluded that the roach nervous system pools information from its thousands of photoreceptors over time—in effect, accumulating electrical neural signals and using the summation of those signals to see.” My comment: If there were no link from light-induced amino acid substitutions to nutrient-dependent cell type differentiation in…

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What about birds?

A sex researcher who typically fails to respond to my comments and questions recently noted that: “New species are only supposed to arise when a population separates into two.” She asked: “So what’s going on with the birds on tiny Santa Cruz Island?” I would have been happy to tell her — if ever she had responded to my past comments. Instead, her question makes good cannon fodder for this blog. See: This Jay Is Evolving in a Very, Very…

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Let there be anti-entropic light (1)

Summary: Light-induced amino acid substitutions link cell type differentiation in plants to nutrient-dependent pheromone-controlled reproduction in animals via the biophysically constrained chemistry of protein folding. Protein folding is perturbed by mutations that limit the ability of organisms to adapt to ecological variation. Viruses contribute to mutations. The sun’s biological energy appears to supply the anti-entropic force that links entropic elasticity to the development of successful morphological and behavioral phenotypes that are exemplified in extant versus extinct biodiversity. The importance of…

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