biophysically constrained

Atheism: Arrogant, useless, and divisive ignorance

Scientific Seeker Stuart Kauffman on Free Will, God, ESP and Other Mysteries By John Horgan | February 4, 2015 Excerpt: Horgan: What do you make of the antipathy toward religion expressed by Richard Dawkins and other “New Atheists?” Kauffman: … moral behavior requires no belief in God. Morality probably evolved in Paleolithic to some extent. But to dismiss those who do believe in God, in any sense, is arrogant and useless and divisive. Excerpt: We need accelerating expansion of universe for…

Read More

Military combat training to fight disease (2)

See: Military combat training to fight disease In the quantum world, the future affects the past Excerpt 1) “It’s not clear why in the real world, the world made up of many particles, time only goes forward and entropy always increases,” Murch said. My comment: Serious scientists are attempting to determine why entropy does not always increase. They realize that feedback loops link cause and effect from the quantum world to the real world of light-induced amino acid substitutions that…

Read More

RNA-mediated epigenetic modification via DNA-methylation

I have repeatedly used the phrase “RNA-directed DNA methylation and RNA-mediated amino acid substitutions” in the context of links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. See for example: RNA-mediated, with links to ~200 blog posts. In the introduction to my 2012 review I attested to the importance of the pathway that links the epigenetic landscape to pharmacogenomics. Excerpt: “The gene, cell, tissue, organ, organ-system pathway is…

Read More

Environment epigenetically shapes the immune system

Environment, more than genetics, shapes immune system 1) –with my emphasis Re: “There’s nothing here that is revolutionary or requires rethinking of our assumptions about how the immune system functions…” My comment: They removed assumptions about cell type differentiation by linking differences in metabolic networks to genetic networks. They indirectly showed that ecological adaptations are nutrient-dependent and the adaptations are controlled by the metabolism of nutrients to species-specific pheromones. The pheromones control the nutrient-dependent physiology of reproduction in species from…

Read More

Constrained evolution is ecological adaptation

See also: Unconstrained evolutionary innovability Ideas that evolution is not constrained can be compared to experimental evidence of biophysically constrained ecological adaptations. The most recent relevant open access published work from the Jakobsson lab is: TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells. This is a link to a prior publication (also open access): microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons Taken together these two published works extend our 1996 model of RNA-mediated cell type differentiation…

Read More

Nothing new under the sun, except pseudoscientific nonsense

On the Importance of Being a Methodological Naturalist Posted on November 5, 2014 by David Sloan Wilson Excerpt: “…consider the flying spaghetti monster, a deity invented to poke fun at religion. It is ridiculous, but is there any way to prove that it doesn’t exist?” Conclusion: “If religious believers abandon methodological naturalism, then they are forced to deny not only the laws of physics and the facts biological evolution, but the histories of their own religions.” My comments: DS Wilson is…

Read More

RNA eclipses the importance of DNA to cell type differentiation

Why skin cells are skin cells and not neurons Excerpt: “…we’re using this approach to identify how the epigenome changes when plants are exposed to challenging environmental conditions, such as drought or high temperature, and how these changes might prime the plants for greater tolerance of subsequent exposures.” My comment: The ‘approach’ is DNA methylation at a time when RNA sequencing has since revealed how the epigenetic landscape becomes the physical landscape of DNA in the organized genomes of species…

Read More

RNA-mediated genetic engineering (Part 2)

WATCH: Bill Nye the Science Guy predicts end of creationism is nigh Excerpt: “Best known as Bill Nye the Science Guy, the 58-year-old educator, TV personality and author lamented the lingering myth that the universe is a product of divine creation.” My comment: Evolutionary theorists have not described a biologically-based evolutionary event that links one species to the evolution of another. The myth of evolution was exposed via the fact that Richard Lenski’s bacteria and Michael Desai’s yeasts did not…

Read More

RNA-mediated genetic engineering

Epigenetics II: Cellular Memory, Imprinting, and Targeting Genome Configuration With RNA Excerpt: “… germline-specific piRNA-targeted epigenetic control is key to understanding how life history events activate natural genetic engineering.” My comment: Researchers are not reporting the molecular epigenetics of RNA-mediated genetic engineering in the context of natural genetic engineering. Indeed, it sometimes seems that other are avoiding mention of links from RNA-mediated cell type differentiation via amino acid substitutions to nutrient-dependent pheromone-controlled ecological adaptations in species from microbes to man.…

Read More

Genomic surveillance ends our world of RNA-mediated ecological adaptations

Why is this woman smiling? 1) Identifying Recent Adaptations in Large-Scale Genomic Data Senior author: Sabeti with co-author Rinn Excerpt: “As natural selection can only act on mutations that drive phenotypic variation…”. 2) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak  Senior author: Sabeti. Excerpt: “Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.” 3) RNA and…

Read More