biophysically constrained

Energy-dependent epigenetic translation to mRNA stability (3)

Energy-dependent epigenetic translation to mRNA stability (2) Energy-dependent epigenetic translation to mRNA stability (2) See for comparison this treatise on climate change packaged as information on the evolution of a flying snake. Fossil ‘winged serpent’ is a new species of ancient snake At the time that Zilantophis dwelled there, the site was a sinkhole surrounded by forest, attracting a variety of animals. The local fauna included ancient representatives of familiar North American creatures such as bears, beavers and salamanders. Others…

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Energy-dependent microRNA biogenesis

Published May 3, 2017 Genetic variation and RNA structure regulate microRNA biogenesis …primary sequence determinants and RNA structure are key regulators of miRNA biogenesis. Genetic variation aka primary sequence determinants are energy-dependent and RNA-mediated. Energy-dependent RNA methylation is an experience-dependent link from natural selection for energy-dependent codon optimality. Natural selection for energy-dependent codon optimality links ATP-dependent microRNA biogenesis to RNA biosynthesis. Ridiculous attempts to portray energy-dependent top-down causation as if genetic variation came first may continue for another 52 years.…

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Draining the academic swamp of parasites

National Academies Revise Conflict of Interest Policy The proposed changes follow revelations in recent years that committee members preparing reports for the Academies did not disclose industry relationships. By Ashley P. Taylor | May 3, 2017 Excerpt: They are also thinking about including not only current activities and relationships, as they do now, but past ones when determining whether or not a committee member has a COI. See for comparison: Ian Hodder: Çatalhöyük, Religion & Templeton’s 25% My comment: Past…

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The death of human ethology via ecology

Nutrient-dependent/pheromone-controlled adaptive evolution: a model Open access publication on June 14, 2013 Mutation-driven evolution also published on June 14, 2013 Variable habitat conditions drive species covariation in the human microbiota http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005435 Open access publication on April 27, 2017 Conclusion: …we found that genetically related species respond to fluctuating habitat conditions in the same way, implying that they occupy similar ecological niches. Thus, current taxonomic groupings of bacteria are largely sufficient for explaining cross-sectional correlations in relative species abundances over the…

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Dispensing with all pseudoscientific nonsense about evolution (1)

No experimental evidence of biophysically constrained biologically-based cause and effect supports claims that the mammalian placenta “evolved.” All experimental evidence of biophysically constrained biologically-based cause and effect supports claims that the mammalian placenta is an energy-dependent pheromone-controlled ecological adaptation. See also: Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory Chemoautotrophic symbiosis is nutrient energy-dependent and pheromone-controlled. Nothing about life involves autotrophy. Everything known to serious scientists links chirality to autophagy, which protects the…

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Virus-driven downsizing of the human brain (4)

Virus-driven downsizing of the human brain (7/1/16) Virus-driven downsizing of the human brain (2) (7/6/16) Virus-driven downsizing of the human brain (3) (8/9/16) Excerpt: A Postdoctoral Researcher threatened me with litigation if I did not remove the tags with his name that linked his works to works at the institution where he works. In an attempt to discuss Breakthrough in understanding how stem cells become specialized More than two years ago, he wrote: We house our animal mouse models in…

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Open Science: Closed to facts about microRNAs

See my 5-part series on: The tipping point? 50, 000 publications Imagine how we could accelerate innovation, stimulate economic growth and all the solutions we need to live on a healthy and sustainable planet, if we were to open up our science fully and allow a free flow of scientific knowledge.” says Kamila Markram, a neuroscientist and the CEO of Frontiers, one of the largest Open Access science publishers in the world and a leader in the Open Science movement.…

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Respiration-dependent endogenous RNA interference

If you are a theorist, please take a deep breath before beginning to read this. The speed of light on contact with water has been linked from the level of oxygen on Earth to all biodiversity via the physiology of pheromone-controlled reproduction and the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes in all living genera. @jvkohl 15h15 hours ago  It’s “game over” for all theorists. There’s a new game in town. https://www.kicktraq.com/projects/geniusgames/cytosis-a-cell-biology-board-game/ … It’s an evolutionary theory killer. @jvkohl…

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Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution

Crystal structure of the overlapping dinucleosome composed of hexasome and octasome My summary: Nucleosomes are dynamic entities that are repositioned by energy-dependent links from sunlight to ATP and RNA biosynthesis that act on DNA during the chromatin remodeling, which is biophysically constrained by the pheromone-controlled physiology of reproduction during the transgenerational epigenetic inheritance of all morphological and behavioral phentoypes. processes. Reported as: Unveiling how nucleosome repositioning occurs to shed light on genetic diseases …an incomplete formation of overlapping dinucleosome may…

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Sunlight bursts the social bubble of physics and math

Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light Under irradiation with visible light, the nicotinamide-dependent enzyme known as ketoreductase can be transformed from a carbonyl reductase into an initiator of radical species and a chiral source of hydrogen atoms. Physicists, mathematicians, and my Facebook friend Paul Harrington, have said nothing about the obvious direct link from the sun’s anti-entropic virucidal energy, which is the source of hydrogen atoms that links the speed of light on contact with water, to…

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