biophysically constrained

Science journalists or paid propagandists? (4)

See first: Dobzhansky 1973 and precision medicine Prognostic value of the MicroRNA-29 family in multiple human cancers: A meta-analysis and systematic review   ….low expression of miR-29 is associated with aggressiveness and poor prognosis of malignant neoplasms. More importantly, miR-29 might serve as a key biomarker for predicting the recurrence and progression of human cancers. Feeding on the Unseen: Ingestion and Assimilation of Bacteriophages by Brachionus plicatilis (Rotifera) ATP Production Increases with Addition of Varying Concentrations of Vespa Amino Acid Mixture…

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Dobzhansky 1973 and precision medicine

MicroRNA-34 directly targets pair-rule genes and cytoskeleton component in the honey bee Our findings point to miR-34-5p as novel regulatory component in the complex molecular cascade that governs insect segmentation and to a broader role of miRNAs in the early development due to the detection of mature transcripts from both 5p and 3p arms for several precursor miRNAs. Thus, this work encourages further investigation to pinpoint miRNAs as fine tuners of insect early development. Anna Di Cosmo‘s group took the…

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Critical values expose virus-driven energy theft (2)

Why Don’t The Amish Get Cancer? …the Amish commitment to simple, productive lives and clean, local food is benefiting their health in ways that the rest of America can only dream about. They exemplify what it means to be an ecologically adapted human population. See also: Past 5,000 years prolific for changes to human genome The facts support the beliefs of young earth creationists. That invites ridicule and denigration of my published works. But the experimental evidence of biologically-based cause and…

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Critical values expose virus-driven energy theft

Critical Values: is ASCP’s quarterly magazine with news and features covering trends of interest to pathologists and laboratory professionals alike. See for example: Attentive Clinical Laboratory Scientist Discovers First Human Case of Borrelia turicatae Critical Values spoke with technologist Dolli Lane, MLT(ASCP)CMCsCM, and the chief of the hematology section, Chris Boyd, MLT(ASCP)CM, about their findings. Their story demonstrates how attention to detail saves lives. Every serious scientist I know is on the verge of linking the creation of the sun’s…

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Energy-dependent chirality

See also: Achiral glycine Summary: Virus-driven energy theft alters the interactions between physics and chemistry that maintain biophysically constrained biodiversity. That’s how viruses are linked from mutations to all pathology. Nutrient energy-dependent changes in the context of the pheromone-controlled physiology of reproduction biophysically constrain biodiversity via the fixation of amino acid substitutions in supercoiled DNA, which protects organized genomes from virus-driven pathology. Chirality (chemistry) Two enantiomers of a generic amino acid that is chiral The chirality of amino acids is energy-dependent…

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Energy-dependent alternative splicings 1996 – 2016 (2)

See also: Energy-dependent alternative splicings 1996 – 2016 Re: Rs3827760 is Val370Ala and EDARV370A No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology. For example, see: Genome recoding by tRNA modifications The succession of mRNA codons controls the synthesis of polypeptides through the complementarity between each of the 64 possible codon triplets and the tRNA anticodons that decode…

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Vietnam Veterans and others with glioblastoma

The Agent Orange Widows Club After their husbands died of an aggressive brain cancer, the widows of Vietnam veterans have found one another as they fight the VA for benefits. See also: Vietnam Veterans with Glioblastoma Multiforme Stage 4 Brain Cancer This post was removed: Targeting NF-κB in glioblastoma: A therapeutic approach This is the level of complexity that the VA needs to understand and link to the treatment of this aggressive cancer, which is obviously caused by virus-driven energy theft.…

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Energy-dependent sensory maps (1996-2016)

Developmental broadening of inhibitory sensory maps My summary: They help to detail how olfactory input causes the energy-dependent de novo creation of sensory maps, which are representations of the external world. The experience-dependent representations link chemotaxis and phototaxis to biophysically constrained behavior. The representations are systematically organized in brain structures throughout development. Simply put, the maps are links from the epigenetic landscape to the physical landscape of supercoiled DNA in organized genomes. By investigating how ongoing neurogenesis in the mouse…

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More refutations of neo-Darwinian nonsense

New CRISPR–Cas systems from uncultivated microbes In bacteria, we discovered two previously unknown systems, CRISPR-CasX and CRISPR-CasY, which are among the most compact systems yet identified. Notably, all required functional components were identified by metagenomics, enabling validation of robust in vivo RNA-guided DNA interference activity in E. coli. Interrogation of environmental microbial communities combined with in vivo experiments allows access to an unprecedented diversity of genomes whose content will expand the repertoire of microbe-based biotechnologies. They discovered that energy-dependent RNA-mediated…

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