brain

MicroRNAs and memory

Diet rich in methionine may promote memory loss Excerpt: “We are looking further into epigenetic factors like microRNA and other downstream genes that could be associated with memory loss.” See also: Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems (an invited review of nutritional epigenetic) Abstract excerpt: “This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The…

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From Hydra to humans vs a Lakatosian research program

Imre Lakatos Excerpt: “A Lakatosian research programme[8] is based on a hard core of theoretical assumptions that cannot be abandoned or altered without abandoning the programme altogether. More modest and specific theories that are formulated in order to explain evidence that threatens the ‘hard core’ are termed auxiliary hypotheses. Auxiliary hypotheses are considered expendable by the adherents of the research programme—they may be altered or abandoned as empirical discoveries require in order to ‘protect’ the ‘hard core’. Whereas Popper was…

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Nothing new under the sun, except pseudoscientific nonsense

On the Importance of Being a Methodological Naturalist Posted on November 5, 2014 by David Sloan Wilson Excerpt: “…consider the flying spaghetti monster, a deity invented to poke fun at religion. It is ridiculous, but is there any way to prove that it doesn’t exist?” Conclusion: “If religious believers abandon methodological naturalism, then they are forced to deny not only the laws of physics and the facts biological evolution, but the histories of their own religions.” My comments: DS Wilson is…

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Making sense of quotes scattered across disciplines

Speaking of Science November 2014’s selection of notable quotes By The Scientist Staff | November 1, 2014 My comment: The quotes are scattered from across disciplines, but can be linked to what is known about conserved molecular mechanisms of biologically-based cause and effect that, in context, make sense of them. 1) Cell type differentiation occurs via amino acid substitutions in the Ebola viruses. Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry 2) What…

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Metabolism, fixation, health or neurodegerative disorder

“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.” Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism My comment: The article links a nutrient-dependent amino acid substitution via changes in metabolism to cell type differentiation, multicellularity, and brain development in Drosophila. It suggests the substitution is fixed by the model organism’s pheromone-controlled…

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Ecological variation and niche construction: 1, 2, 3

Part 1 From its most basic expression in grazing and predatory nematodes with differences in morphological and behavioral phenotypes, neurogenic niche construction is nutrient-dependent and pheromone-controlled. One of these two worms has teeth. It also recognizes self vs other differences and eats other worms. “The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes. Evolutionary theorists concluded and continue to claim that “…without mutation, evolution would not…

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Epigenetically-effected metabolic shifts and ecological adaptations

Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, monomethylation of histone H3 at lysine 4, and acetylation of histone H3 at lysine 27. They also analyzed genome-wide transcription and transcription factor binding. Together…

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Behavior (2): All responses are RNA-mediated not genetically-determined

Diana Maria Petrosanu also asked: “who was the author of the article that had stolen your ideas?“ I cannot recall claiming that anyone had stolen our ideas or my ideas. See: Behavior: The first response is RNA-mediated not genetically-determined. In subsequent published works, I extended what we detailed about the molecular epigenetics of sex differences in cell types from yeasts to mammals via examples from model organisms of RNA-mediated cell type differentiation in different species. That is why I was…

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Jay R. Feierman

In his posts that I have linked below, Jay R. Feierman takes us from random mutations on which natural selection acts to natural selection for phenotypes and changes in the brain that lead to increased reproductive success. According to him, the change in the brain can be called an adaptation. In my model, ecological variation and nutrient-dependent pheromone-controlled epigenetically-effected ecological, social, neurogenic, and socio-cognitive niche construction enable organismal complexity of the human brain. Ecological variation links the epigenetic landscape to…

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