Caenorhabditis elegans

Host-derived creation of all pathology (2 of 2)

Summary: All serious scientists know that all epigenetic diversity is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. See for comparison: Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.” A Bacterial Messenger Molecule Extends Healthspan …indole,…

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The death of CRISPR; long live endogenous RNAi

The future of human genome editing Published online 26 April 2017 …there are currently few genetic arguments for the necessity of correcting the genetic material of future generations given preimplantation diagnosis of monogenic conditions. The death of the CRISPR Cas9 may seem to have come quickly, but see also: Kalevi Kull: Censorship & Royal Society Evo Event Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of…

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Theistic evolutionists fight back and lose

A giant neuron found wrapped around entire mouse brain Yuste and Eberwine would like to see 3D reconstructions of individual neurons compared to analyses of the genes expressed in those neurons. This may offer clues as to the type and function of each cell. The nutrient energy-dependent structure and function of all cell types in all living genera links biodiversity from the physiology of pheromone-controlled reproduction in C. elegans to the predatory behavior of P. pacificus, a predatory nematode with…

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Wikipedia refutes theistic evolution

RNA-Directed DNA Methylation Besides RNA molecules, a plethora of proteins are involved in the establishment of RdDM, like Argonautes, DNA methyltransferases, chromatin remodelling complexes and the plant-specific Polymerase IV and Polymerase V. All these act in concert to add a methyl-group at the 5′ position of cytosines. In contrast to animals, cytosines at all sequence context (CG, CHG, CHH) may get de novo methylated in plants. There is no such thing as de novo methylation. Methylation is energy-dependent. Virus-driven energy…

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Pseudoscientists fail to refute theistic evolution

Darwinism for the Genomic Age: Connecting Mutation to Diversification …the chief cause of our natural unwillingness to admit that one species has given birth to other and distinct species, is that we are always slow in admitting any great change of which we do not see the intermediate steps. (Darwin, 1859) Darwin put energy-dependent “conditions of life” before what is now known about natural selection for codon optimality. That is the chief cause for ignoring anything that neo-Darwinists claim about…

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Energy is information. Objections over ruled. You’re fired!

Objection: In the law of the United States of America, an objection is a formal protest raised in court during a trial to disallow a witness’s testimony or other evidence which would be in violation of the rules of evidence or other procedural law. Americanism (ideology) links the laws of United States of America to God’s “Laws of Biology.”  Pseudoscientists violated the rules of evidence that link Darwin’s “conditions of life” from God’s “Laws of Biology” to all nutrient energy-dependent…

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From precis to pre-mRNA and proof of concept in F1, F2, F3

The Gene Ontology Handbook, edited by Christophe Dessimoz & Nives Škunca Open Access, Download it here See also: New trends in evolutionary biology: biological, philosophical and social science perspectives November 7-9, 2016 See also: BioGenomics 2017 – Global Biodiversity Genomics Conference February 21-23, 2017 See also: Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans Conclusion: The current limiting factor in using this technology is the availability of fast-acting ts alleles. Previous forward genetic screens for ts alleles…

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Chromatin: The structure of DNA (2)

A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation Excerpt (with my emphasis): Highlights •    A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed. •    Dynamics and replication timing of Xi were visualized. •    Critical amino acids for the stability and/or folding of the mintbody were revealed. Reported as: Catching histones by the tail: A new probe to track histone modifications in living cells Excerpt: H4K20me1 is most likely associated with the tight packing of a redundant (inactivated) female X…

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Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Half truths support theories without facts

How to lie by telling the truth Excerpt: People… trot out half-truths, in full expectation and knowledge that they will create a false impression. And then, when others act on the false impression, the “truth-telling liars” can sit back and pretend that they aren’t liars. They get the benefit of lying, without any damage to their precious self-image. My comment: It is more difficult for others to determine who benefits from half truths when more than one individual or research…

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