Cancer Treatment

Codon optimality vs systemic fraud (5)

Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells 6/27/22 links more than 144,000 other publications that mention miRNAs from Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 to patented therapeutic solutions that help to protect organized genomes from the virus-driven degradation of messenger RNA. See: Results Codon optimality vs systemic fraud (5)

Chemogenetic kinetics (4): Darwinism vs neo-Darwinism

The paradigm shift in the molecular epigenetics section of  From Fertilization to Adult Sexual Behavior has turned neo-Darwinists into Darwinists who link energy-dependent “conditions of life” to the prevention of virus-driven hecatombic evolution. See:  Virus-mediated archaeal hecatomb in the deep seafloor for comparison to  Eukaryotic plankton diversity in the sunlit ocean. Cancer researchers now try Chemogenetic kinetics (4): Darwinism vs neo-Darwinism

RNA-mediated radiosensitivity (1)

I posted this to microRNA.pro after resolve of an access issue. It now appears as part two of The Tipping Point (revisited): 90K (2) I will follow up on the link to RNA-mediated radiosensitivity after consideration of Maximum Entropy (Most Likely) Double Helical and Double Logarithmic Spiral Trajectories in Space-Time, which was reported in today’s RNA-mediated radiosensitivity (1)

Energy-dependent allelic imbalances, viruses, and pathology

Energy as information and constrained endogenous RNA interference poster presentation February 15, 2017 KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer February 23, 2017 These studies demonstrate that serial genetic changes at the Kras/KRAS locus are frequent in cancer and modulate competitive fitness and MEK dependency. Reported as: Genetic ‘balance’ may Energy-dependent allelic imbalances, viruses, and pathology

GC-rich neo-Darwinian train wreck

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells Excerpt: In this study, we demonstrate direct cellular reprogramming to induced neuronal cells through targeted activation of endogenous genes. Excerpt: Moreover, a recent study demonstrated that reprogramming efficiency can be limited by divergence to a competing cell identity (Treutlein GC-rich neo-Darwinian train wreck