Cancer

The assassination of intelligence (2)

The assassination of intelligence (1) God’s Creation of hydrogen is the link from nuclear energy to healthy longevity via the biology of protein-folding chemistry. Seasons greetings from God via what is known about His light-activated Creation of the endoplasmic reticulum, which helps to ensure biophysically constrained viral latency. Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer 12/2/20 links the reassembly of viruses and viral fragments in vaccines to the need for an mRNA vaccine to obfuscate what is…

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The tipping point (revisited): 110K (2)

Democrats seem to believe that President Trump’s claims about UV light and humidity have not been linked from the end of the COVID-19 nonsense to the end of their party, the end of Communism, the end of atheism, the end of racism and the end of all the liberal BS. Is the link from God’s Creation of UV light and water to ATP-dependent oxidative phosphorylation not perfectly clear to all intelligent people? See for review: From Fertilization to Adult Sexual…

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pH-dependent viral latency (7)

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots  6/12/20 …we demonstrate that the RNA mutation-based APOBEC3A assay is applicable to clinical samples from cancer patients. Our study presents a strategy to follow the dysregulation of APOBEC3A in tumors, providing opportunities to investigate the role of APOBEC3A in tumor evolution… Reported as: Monitoring RNA hotspots reveals target in cancer tumor cells by University of California, Irvine The targeting is microRNA-mediated. Proteins do not create themselves…

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RNA-mediated radiosensitivity (1)

I posted this to microRNA.pro after resolve of an access issue. It now appears as part two of The Tipping Point (revisited): 90K (2) I will follow up on the link to RNA-mediated radiosensitivity after consideration of Maximum Entropy (Most Likely) Double Helical and Double Logarithmic Spiral Trajectories in Space-Time, which was reported in today’s news as Kepler’s Forgotten Ideas about Symmetry Could Explain Spiral Galaxies Without the Need for Dark Matter 8/8/19 Watch as everything known about biophysically constrained…

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Natural models inspire future therapeutics

Natural models inspire future therapeutics See: Screaming viruses and Alzheimer’s (1) Screaming viruses and Cancer Screaming Viruses and Alzheimer’s (2) MicroRNA biogenesis, the microRNAome, and your brainome and Reciprocal Interactions Between Gut Microbiota and Host Social Behavior We suggest that investigating these reciprocal interactions can advance our understanding of sociality, from healthy and impaired social cognition to the evolution of specific social behaviours and societal structure. There is no natural model of evolved social behavior. I suggest that all theorists…

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The eternal significance of microRNAs (10)

ETERNAL:  lasting or existing forever; without end or beginning. SYNONYMS everlasting, never-ending, endless, perpetual, undying, immortal, abiding, permanent, enduring, infinite, boundless, timeless IN CONTEXT (of truths, values, or questions) valid for all time; essentially unchanging EXAMPLE: eternal truths of art and life” EXAMPLE:  The Vietnam Veterans Memorial Wall is a wall of eternal significance. The parents of the architect left China before the Communist take-over. Scientific creationists from South Korea have since linked the efforts of the US Military forces…

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The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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The eternal significance of microRNAs (2)

Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril. The Immune Landscape of Cancer (2018) Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune…

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Enzyme-constrained interethnic biodiversity (4)

No, they don’t. See: Why Is This Bacterium Hiding in Human Tumors? Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be “an integral part of the cancer.” Serious scientists have linked bacteriophages to all virus-driven pathology. Cancer is a virus-driven pathology. That’s the truth! In  the New York Times article by Gina Kolata she wrote: “The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon…

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Enzyme-constrained interethnic biodiversity (3)

Excerpt: Understanding a “correlational mechanism” is like understanding mutation-driven evolution. You have a mutation. You have evolution. Thus, you understand the simple-minded magic of the correlation. No energy-dependent molecular mechanisms are required. For comparison: Enzyme-constrained interethnic biodiversity is exemplified in Amish populations in the United States of America. Obviously, interethnic difference in genes matter. See: Low cancer incidence rates in Ohio Amish (2009) Why Don’t The Amish Get Cancer? (2016) See also: A null mutation in SERPINE1 protects against biological…

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