Cancer

Natural models inspire future therapeutics

Natural models inspire future therapeutics See: Screaming viruses and Alzheimer’s (1) Screaming viruses and Cancer Screaming Viruses and Alzheimer’s (2) MicroRNA biogenesis, the microRNAome, and your brainome and Reciprocal Interactions Between Gut Microbiota and Host Social Behavior We suggest that investigating these reciprocal interactions can advance our understanding of sociality, from healthy and impaired social cognition to the evolution of specific social behaviours and societal structure. There is no natural model of evolved social behavior. I suggest that all theorists…

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The eternal significance of microRNAs (10)

ETERNAL:  lasting or existing forever; without end or beginning. SYNONYMS everlasting, never-ending, endless, perpetual, undying, immortal, abiding, permanent, enduring, infinite, boundless, timeless IN CONTEXT (of truths, values, or questions) valid for all time; essentially unchanging EXAMPLE: eternal truths of art and life” EXAMPLE:  The Vietnam Veterans Memorial Wall is a wall of eternal significance. The parents of the architect left China before the Communist take-over. Scientific creationists from South Korea have since linked the efforts of the US Military forces…

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The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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The eternal significance of microRNAs (2)

Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril. The Immune Landscape of Cancer (2018) Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune…

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Enzyme-constrained interethnic biodiversity (4)

No, they don’t. See: Why Is This Bacterium Hiding in Human Tumors? Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be “an integral part of the cancer.” Serious scientists have linked bacteriophages to all virus-driven pathology. Cancer is a virus-driven pathology. That’s the truth! In  the New York Times article by Gina Kolata she wrote: “The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon…

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Enzyme-constrained interethnic biodiversity (3)

Excerpt: Understanding a “correlational mechanism” is like understanding mutation-driven evolution. You have a mutation. You have evolution. Thus, you understand the simple-minded magic of the correlation. No energy-dependent molecular mechanisms are required. For comparison: Enzyme-constrained interethnic biodiversity is exemplified in Amish populations in the United States of America. Obviously, interethnic difference in genes matter. See: Low cancer incidence rates in Ohio Amish (2009) Why Don’t The Amish Get Cancer? (2016) See also: A null mutation in SERPINE1 protects against biological…

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Quantized energy-dependent viral trophism (3)

Summary: If the pathway is ancestral, how and when did it evolve to protect species from microbes to humans from the virus-driven degradation of their messenger RNA? Peer-Reviewed Science: A “Mathematical Proof of Darwinian Evolution” Is Falsified The theorem addresses only the effects of natural selection. Fisher did not directly address any other effect (mutation, genetic drift, environmental change, etc.) as he considered them to be insignificant. Later mathematicians took issue with Fisher’s lack of rigor, some at considerable length.…

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A Mathematical Model Links Quantum Physics to Quantum Souls (1)

Historical facts: All energy-dependent cell type differentiation is biophysically constrained by the de novo creation of microRNAs and enzymes that metabolize food and drugs. All food energy-dependent metabolism occurs in the context of microRNA-mediated cause and effect and the physiology of pheromone-controlled reproduction. The food energy-dependent pheromone controlled physiology of reproduction in bacteria links what organisms eat to the transgenerational epigenetic inheritance of their morphological and behavioral phenotypes. The virus-driven degradation of messenger RNA has been linked to all pathology…

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Exome Sequencing Impact in Routine Care

Summary: They placed the pseudoscientific nonsense about selection for beneficial mutations into the context of positive selection for mutations, which are caused by the virus-driven degradation of messenger RNA. The mutations have been linked to all pathology. It’s as if all theorists want to become known as “biologically uninformed science idiots” via their associations with others who have touted claims about “beneficial mutations.” US Air Force Studying Impact of Exome Sequencing in Routine Care Who, among my fellow veterans, and…

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Criticisms of a validated model

Microglia Turnover in the Human Brain “With electron microscopy, we find a variety of immune cells in the brain, especially in contexts of disease,” she writes. Richard Feynman predicted this in the context of a lecture on nanotechnology. He presciently placed cryo-EM into the context of a lecture about Plenty of Room at the Bottom. Examination at this level of observable energy-dependent top-down causation has since linked the sun’s anti-entropic virucidal energy from hydrogen-atom transfer in DNA base pairs in…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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