Cancer

Neo-Darwinian sink testing

sink testing Lab medicine The illegal practice of providing false test results on clinical specimens–eg, vials of blood, urine specimens, that were deliberately discarded–ie, down the sink, without actually testing them Pylori Story #1: Acid Attack Pylori Story #2: Journey to the Center of the Stomach My comment: The “Modern Synthesis” is analogous to sink testing in the medical laboratory. It was invented in the early 1900’s based on de Vries definition of jump-like energy changes, which he called “mutations.”…

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NORAD: air defense and defense against genomic entropy

NORAD may refer to: North American Aerospace Defense Command… that provides aerospace… defense for North America Norwegian Agency for Development Cooperation Noradrenaline, a hormone and a neurotransmitter with multiple biological roles My comment: The modern use of radar includes air-defense systems and ocean surveillance systems.  High tech radar systems are designed to use the systems complexity of signaling and sensing to extract useful information from levels of very high noise.  In the context of protection from virus-driven genomic entropy use…

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RNA-mediated theory killers (4)

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Excerpt: At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for cancer diagnosis. My comment: The SLC19A3 microRNA was mentioned in the context of cancer and brain development in The impact of new technologies on clinical decision-making in health care. The location of the base…

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A two-faced protein enables RNA-mediated DNA repair (3)

See: A two-faced protein enables RNA-mediated DNA repair (2) See: A two-faced protein enables RNA-mediated DNA repair My comment: Attempts to place what is currently known about the links from atoms to ecosystems back into the context of neo-Darwinian pseudoscientific nonsense have been doomed to fail ever since Dobzhansky (1973) wrote: Nothing in Biology Makes Any Sense Except in the Light of Evolution. He linked nutrient-dependent amino acid substitutions to cell type differentiation across species and also claimed “…the so-called…

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Cancer: forward and reverse

The convergent cancer evolution toward a single cellular destination Abstract excerpt: …cancer evolution is a directional process toward a defined cellular destination, a finding reconciling development and evolution, the two seemingly incompatible philosophies both adopted by the cancer research community, and also raising new questions to evolutionary biology. My comment: The idea that cancers evolve and the idea that species evolve are not compatible. Taken  together, the incompatible ideas that have been adopted by cancer researchers led to 32 years…

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Alternative pre-mRNA splicing and ecological adaptation

This startup thinks it can speed up a cure for cancer by bringing scientific research into the YouTube era Excerpt: The current scholarly publishing model did not allow me to present the research I was doing. I created [Figshare] initially out of purely selfish reasons and I spent my evenings and weekends creating a platform that allowed me show, in a super simple way, data sets, and videos to put me ahead of the rest of my peers. I’ve used…

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Information and communication

Intelligent Cancer Cells Communicate with Exosomes Excerpt: Human cells use thousands of different types of signals—cytokines, chemokines, neurotransmitters, gliatransmitters, peptides, protein factors, photons, mRNA, miRNA, lncRNA and many types of electricity (electrical synapses, calcium waves, axon spikes, protein gradients, electric fields, synchronous oscillations). Communication between cells occurs at many different levels at the same time. My comment: Theorists include this communication of information in human cells, but they fail to address the obvious need to link the different types of…

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Missing a fact: microRNAs are genomic biomarkers

Summary: The nutrient-dependent microRNA/messenger RNA balance links virus-induced entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent protein biosynthesis and degradation to everything that is currently known about RNA-directed DNA methylation and RNA-mediated amino acid substitutions. The substitutions differentiate the cell types of all genera. That fact is not being reported in most of the extant literature on healthy longevity and/or pathology. Here is another example of the failure to report facts about biologically-based cause and effect. Note, specifically, this…

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Implicating microRNAs in cancer

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis Reported as: In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution Excerpt: “Unexpectedly, the screen also implicated several microRNAs — small RNA segments that are functional in the cell. More experimental work remains to fully explore the genes and microRNAs uncovered in the screen.” It is the perturbed balance of viral microRNAs and nutrient-dependent microRNAs that obviously makes the difference between RNA-directed DNA methylation and…

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Are viruses microRNAs? (2)

The role of microRNAs in cell type differentiation can be compared in the context of the role of viruses and mutations that cause cancer. Facts provide a basis for explaining the biological basis of epigenetically-effected cell type differentiation in species from microbes to man. But first, those who are biologically uninformed must answer the question: Are viruses microRNAs? Andrew Jones aka anonymous_9001 is correct. Viruses are not microRNAs. anonymous_9001 5 / 5 (6) 11 hours ago Stupid question of the…

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