Cancer

Information and communication

Intelligent Cancer Cells Communicate with Exosomes Excerpt: Human cells use thousands of different types of signals—cytokines, chemokines, neurotransmitters, gliatransmitters, peptides, protein factors, photons, mRNA, miRNA, lncRNA and many types of electricity (electrical synapses, calcium waves, axon spikes, protein gradients, electric fields, synchronous oscillations). Communication between cells occurs at many different levels at the same time. Information and communication

Missing a fact: microRNAs are genomic biomarkers

Summary: The nutrient-dependent microRNA/messenger RNA balance links virus-induced entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent protein biosynthesis and degradation to everything that is currently known about RNA-directed DNA methylation and RNA-mediated amino acid substitutions. The substitutions differentiate the cell types of all genera. That fact is not being reported in most of the Missing a fact: microRNAs are genomic biomarkers

Implicating microRNAs in cancer

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis Reported as: In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution Excerpt: “Unexpectedly, the screen also implicated several microRNAs — small RNA segments that are functional in the cell. More experimental work remains to fully explore the genes and microRNAs Implicating microRNAs in cancer

Are viruses microRNAs? (2)

The role of microRNAs in cell type differentiation can be compared in the context of the role of viruses and mutations that cause cancer. Facts provide a basis for explaining the biological basis of epigenetically-effected cell type differentiation in species from microbes to man. But first, those who are biologically uninformed must answer the question: Are viruses microRNAs? (2)

Nothing new under the sun, except pseudoscientific nonsense

On the Importance of Being a Methodological Naturalist Posted on November 5, 2014 by David Sloan Wilson Excerpt: “…consider the flying spaghetti monster, a deity invented to poke fun at religion. It is ridiculous, but is there any way to prove that it doesn’t exist?” Conclusion: “If religious believers abandon methodological naturalism, then they are forced Nothing new under the sun, except pseudoscientific nonsense

Complex behaviors of cell types in cancer

Decoding the emergence of metastatic cancer stem cells Excerpt: “By applying a physics-based approach to understand the dynamics of cancer decision-making, we were able to explain a number of recent experimental observations, including some that seemed contradictory.” My comment: The logic of the physics-based approach links physics, chemistry, biology, and math, etc. to conserved molecular Complex behaviors of cell types in cancer

RNA-mediated events: chromosomal rearrangements and genomic rearrangements

The Architecture of a Scrambled Genome Reveals Massive Levels of Genomic Rearrangement during Development Excerpt: “Genome-wide DNA rearrangements are most exaggerated in ciliates, particularly in the model organism Oxytricha trifallax, which programs not only DNA deletion, but also total reorganization, through RNA-mediated events (Fang et al., 2012; Nowacki et al., 2008). ” My comment: The RNA-mediated events: chromosomal rearrangements and genomic rearrangements

Nutrition, pheromones and cancer (2)

See: Nutrition, pheromones and cancer Despite the inaccurate reporting of exeperimental evidence, the link from the nutrient-dependent pheromone-controlled microRNA / messenger RNA balance is becoming clearer. Unfortunately, due to the inaccurate reporting, others may need to take the free course: Epigenetic Control of Gene Expression, before they can begin to understand the scientific progress in Nutrition, pheromones and cancer (2)