Carmen Leitch

1996-2016: Ignoring alternative splicings of pre-mRNA

Range of diseases may result when brain self-regulation goes awry, researchers say There is no such thing as self-regulation of the brain. Regulation is food energy-dependent and biophysically constrained by changes in the microRNA/messenger RNA balance. The entire range of diseases is linked from the virus-driven degradation of messenger RNA to the mutations that some theorists claim may sometimes be beneficial.The theorists the make those ridiculous claims are biologically uninformed science idiots. See for comparison: Microprocessor Recruitment to Elongating RNA…

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Survivors of RNA-mediated terrorism

In Darwin’s Radio and Darwin’s Children, Greg Bear predicted there would be ecologically adapted survivors of the forthcoming viral apocalypse.  Could his “raw insight” help to save you, or help to save any of your loved ones who are not already dead? Or, is it too late for us all? See: “The Darwin Code: Intelligent Design without God” Excerpt:  Once again, evolution is a fresh territory, much larger than anyone thought. The Darwin code–the key to all of our new…

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The human virome (revisited)

From October 2013: Describing the Silent Human Virome with an Emphasis on Giant Viruses “…viruses infect all domains of life, including bacteria, archaea and eukaryotes, and are found in all ecological niches [2]. This pleiotropic distribution on our planet allows viruses to play the role of ‘natural motors’ that drive global energy and nutrient cycling [3,4].” My comment: The portrayal of viruses as ‘natural motors’ is made outside the context of the fact that the energy-dependent changes attributed to the…

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GC-rich neo-Darwinian train wreck

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells Excerpt: In this study, we demonstrate direct cellular reprogramming to induced neuronal cells through targeted activation of endogenous genes. Excerpt: Moreover, a recent study demonstrated that reprogramming efficiency can be limited by divergence to a competing cell identity (Treutlein et al., 2016). The molecular mechanisms and practical consequences of these limitations are largely unknown. My comment: They demonstrate what naturally must occur to link…

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