RNA-Mediated

See first: Orchestrated death: Francis S. Collins (2) Exogenous miRNAs induce post-transcriptional gene silencing in plants 10/14/21 was reported on 10/21/21 as Plants Use RNA to Talk to Neighbors A study finds that plants sharing the same growth medium can exchange microRNAs that silence genes in the recipient, suggesting the nucleic acids may act as signaling molecules. Light-activated microRNA biogenesis in plants has been linked from food energy-dependent pheromone-regulated genetic processes of reproduction across kingdoms via the role of nucleic…

Natural selection for adaptation (7)

August 31, 2021

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome 8/31/21 was reported as: High virus count in the lungs drives COVID-19 deaths 8/31/21 …the study revealed that those who died had on average 50 percent lower production of a type of immune chemical that targets the coronavirus compared with the COVID-19 patients who survived the illness. These customized proteins are part of the body’s adaptive immune system, a subset of cells and chemicals…

Impeaching the God of Abraham (4)

February 22, 2021

Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA–Mediated Epigenetic Heredity, Subatomic

Apple Peel and Flesh Contain Pro-neurogenic Compounds 2/11/21 …mammals evolved with exposure to particular diets… How could theorists continue to miss the obvious connection from light-activated plant growth to food energy, microRNA-mediated viral latency, and healthy longevity? See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20 …naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology. See also: Feedback loops link odor and pheromone signaling with reproduction 11/18/05 Indications that GnRH peptide plays an…

microRNA-mediated quantum error correction (3)

October 26, 2020

Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA interference

See: microRNA-mediated quantum error correction (1) On 10/19/20, more than 250 additions to the indexed articles that mention the term ‘microRNA’ appeared after 5 days of what appeared to be a moratorium linked to publication of Thousands of Previously Unknown Phages Discovered in Whole-community Human Gut Metagenomes on 10/14/20. See also: Before Virus, After Virus: A Reckoning 10/15/20 The pandemic has energized us, yes, but it has also provided a necessary dose of humility. It has also been a call…

UV light, H2O, and epigenetic effects… (1)

September 25, 2020

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity

2 Comments

See first: Coherently organized healthy longevity (4) UV light, H2O, and epigenetic effects affect behavior and sympatric speciation Submitted by James V. Kohl on 9/25/20 for presentation during the Epigenetics – From Bench to Clinic session: RNA modifications and epitranscriptomics Moderator Tony Kouzarides Title: UV light, H2O, and epigenetic effects affect behavior and sympatric speciation James V. Kohl* MicroRNA.pro Introduction UV light-activated, H2O-dependent oxidative phosphorylation links microRNA-mediated epigenetic effects on organized genomes from bench to clinic. For a historical perspective,…

NHEJ disruption and HDR correction?

June 14, 2018

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, What's in the News

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

The eternal significance of microRNAs (2)

April 12, 2018

Adaptations, base editing, Cytosis, Diseases & Disorders, Ecology, RNA Directed

Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril. The Immune Landscape of Cancer (2018) Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune…

Who created your virus-driven death gene? (2)

December 12, 2017

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, Variations

Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity These findings indicate that the substitution of glycine for a chiral amino acid in GnRH during evolution allows a more constrained conformation for receptor binding and that this subtle single amino acid substitution in a site remote from the ligand functional domains has marked effects on its structure and activity. The difference between an energy-dependent RNA-mediated amino acid substitution and a mutation has been largely ignored as pseudoscientists linked accidents…

Who created your virus-driven death gene? (1)

November 23, 2017

Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed