cell type differentiation

Part 3: Light-controlled cell biology (revisited)

March 23, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Your cells are constantly being shed and replaced—so is your body ever completely refreshed? Does anything remain of the body that existed on Jan. 1, 2017? 2007? The day you were born? (video) Out of Order: Undaunted  …as I prepared for this issue’s Special Report on Microbiomics (starting on page 19), I am stunned by what I am only starting to understand. That our individual existence as humans may only be 10 percent of what we see in the mirror—and…

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The MicroRNAome Strikes Back: A Sokalian hoax (2)

January 23, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, Subatomic, Variations
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The problem with -omics has repeatedly been detailed in articles from social scientists and other theorists who fail to link what is known to serious scientists about the microRNAome to their theories. Pseudoscientists continue to create bricks that clutter the metaphorical physical landscape and prevent the epigenetic landscape from being linked from the physiology of nutrient energy-dependent pheromone-controlled reproduction to all cell type differentiation via energy-dependent changes in atoms to ecosystems in all living genera. On 1/22/18, I discussed this with…

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Cryo-EM from atoms to ecosystems

October 6, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, RNA Directed
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Summary: I’m not going to continue repeating myself indefinitely. See: Reduced protein synthesis in schizophrenia patient-derived olfactory cells The reduced protein synthesis is a clear link from the virus-driven degradation of messenger RNA to all pathology. October 5, 2017 Lactate Metabolism in Human Lung Tumors Reported as: Study challenges long-standing concept in cancer metabolism “We were completely shocked by our findings,” said Dr. Ralph DeBerardinis, Professor at CRI, Director of CRI’s Genetic and Metabolic Disease Program, and Chief of the Division…

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Host-derived creation of all pathology (1 of 2)

August 25, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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Hunter-gatherers’ seasonal gut-microbe diversity loss echoes our permanent one For more than 15 million years, human beings have co-evolved with thousands of microbial species… Nothing known to serious scientists support ridiculous claims about 15 million years. See for comparison: Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees See also: Nothing in Biology Makes Any Sense Except in the Light of Evolution …the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and…

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Your indifference is killing you and others (4)

August 15, 2017
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Physics, RNA Directed, RNA-directed DNA methylation, Subatomic, Variations
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Summary: I suspect that Subatomic, like Cytosis, will help link atoms to ecosystems via my model of nutritional epigenetics and the pheromone-controlled visual perception of mass and energy, which has been linked from the sense of smell in bacteria across the space time continuum via olfaction. From 7 years ago. Published 7 years ago on 15 Aug 2010 by James V. Kohl of Pheromones.com, RNA-mediated.com, and Autophagy.pro Kohl is the co-author of “The Scent of Eros” and he is the…

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Irreconcilable differences: food energy vs de novo assembly

August 1, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Developmental dynamics and contemporary evolutionary psychology: status quo or irreconcilable views? Reply to Bjorklund (2003), Krebs (2003), Buss and Reeve (2003), Crawford (2003), and Tooby et Al. (2003). The authors argue that evolutionary psychology currently offers no coherent framework for how to integrate genetic, environmental, and experiential factors into a theory of behavioral or cognitive phenotypes. An evolutionary perspective on the systems of adaptive immunity We propose a revival of the concept of the ‘Big Bang’ of vertebrate immunity, arguing…

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New Testament Book Cover Refutes Theistic Evolution

July 31, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

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God’s shrinking role in salvation (3)

June 16, 2017
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
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Summary: I believe there is a bipartisan trend that links conservative Republicans to survival of the species, but I don’t know for sure what will happen to the liberal Democrats. And, I can’t prove it!   Helicity and chirality https://www.facebook.com/ed.unverricht/videos/10155506720828729/ See also: God’s shrinking role in salvation (2) A Theory of Reality as More Than the Sum of Its Parts “Causal emergence is a way of claiming that your agent description is really real,” said Hoel, a postdoctoral researcher at…

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MicroRNAs light up life

June 2, 2017
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Every aspect of cell type differentiation or mutation-driven pathology occurs downstream from the de novo creation of energy-dependent microRNAs. That fact should be considered in all aspects of top-down causation, which must link the sun’s energy to behavior via the physiology of reproduction and chromosomal inheritance. On a relational theory of biological systems: a natural model for complex biological behavior (5/29/17) In this paper, we develop a natural (empirical) relational theory for describing and modeling complex biological phenomena. We…

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From E. coli to monkeys and mankind: Theories vs models (2)

May 28, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Dedicated to Dr. Tom Jordan and Priscilla Jordan on the day of their retirement from the Baptist ministry, May 28, 2017. They always encouraged me to learn more about the “Laws of Biology” and link the Laws from energy as information to all biodiversity on Earth via the physiology of reproduction. See also: From E. coli to monkeys and mankind: Theories vs models High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding (5/23/127) …changes in observed association…

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