cell type differentiation

Codon optimality vs systemic fraud (1)

June 5, 2022
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Two summaries of neo-Darwinian evolutionary theory: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. …yeast receptors trigger activation of heterotrimeric G proteins just as mammalian receptors do, this conserved signaling pathway must have been present in the common ancestor of yeast and humans. Unless you are a biologically uninformed theorist, see first Epistemic corruption (10) Watch for my next 10-part series on Codon optimality vs systemic fraud. I will link it to the fraudulent representations…

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MicroRNA-mediated existential threats (8)

May 2, 2022
James Kohl
Adaptations, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Natural processes link light-activated microRNA biogenesis to pH-dependent prevention of viral infections. The natural processes are energy-dependent and biophysically constrained by the pheromone-regulated genetic processes of reproduction across kingdoms from microbes to humans. Follow me @microRNApro on Twitter if you want to help others prevent virus-driven existential threats to humanity. See also: MicroRNA.pro, http://Autophagy.pro & continue to follow me on http://RNA-mediated.com as I link God’s Creation of subatomic particles from pH-dependent peptide synthesis to sympatric speciation and healthy ecosystems…

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MicroRNA-mediated existential threats (3)

April 23, 2022
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, replication timing, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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“Footprints of Multiple Interspecies Re-assortment Events” (4/16/18) link the failed efficacy of COVID19 vaccines,  to the microRNA-mediated future of humanity via patents held for therapeutic solutions by Thomas E. Eichim et al., in the context of former President Trump’s claim on 4/23/20 about light-activated protein folding chemistry and Characteristics of the MicroRNA Expression Profile of Exosomes Released by Vero Cells Infected with Porcine Epidemic Diarrhea Virus  (indexed on 4/23/22) Details: Exosomes… contain regulated microRNA (miRNA), allowing them to function in…

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Photonics in Forensics (8)

March 11, 2022
James Kohl
RNA Directed
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Light-activated carbon fixation, the resurrection of life in pear trees, and the resurrection of life in daffodils exemplifies how God’s pH-dependent peptide synthesis at the origin of life ~6000 years ago links microRNA-mediated  protein folding chemistry to protection of all organized genomes from the virus-driven degradation of messenger RNA (mRNA). For instance, see: Integrative global co-expression analysis identifies Key MicroRNA-target gene networks as key blood biomarkers for obesity 3/10/22 They linked God’s Creation of energy-dependent transcription factor networks to computational…

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Protonated RNA interference vs stupid theories (4)

November 2, 2020
James Kohl
Adaptations, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, RNA Directed, RNA interference, Subatomic
One Comment

Remember, a vote for Joe Biden, and/or other Democrats, is a vote for more unnecessary suffering and premature deaths. See first: Protonated RNA interference vs stupid theories (3) See also: The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls 10/22/20 Comparison with previous reports on axolotl miRNAs unraveled common and unique members of the axolotl circulating miRNome. Overall, this work provides novel insights into non-mammalian aspects of circulating miRNA biology and expands the multi-omics toolkit for…

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Epigenetic inheritance of spatiotemporal regulation (3)

May 24, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Summary: Wen Zhou’s group has linked the creation of anti-entropic virucidal light from the quantized energy-dependent creation of microRNAs to the food energy-dependent neuroendocrine origins of human behavior via the pheromone-controlled physiology of reproduction and fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Simply put, she has linked quantum physics to quantum souls via what is known about biophysically constrained viral latency in the context of the cell biology game Cytosis and the future of biology.…

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Part 3: Light-controlled cell biology (revisited)

March 23, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Physics, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Your cells are constantly being shed and replaced—so is your body ever completely refreshed? Does anything remain of the body that existed on Jan. 1, 2017? 2007? The day you were born? (video) Out of Order: Undaunted  …as I prepared for this issue’s Special Report on Microbiomics (starting on page 19), I am stunned by what I am only starting to understand. That our individual existence as humans may only be 10 percent of what we see in the mirror—and…

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The MicroRNAome Strikes Back: A Sokalian hoax (2)

January 23, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA-directed DNA methylation, Subatomic, Variations
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The problem with -omics has repeatedly been detailed in articles from social scientists and other theorists who fail to link what is known to serious scientists about the microRNAome to their theories. Pseudoscientists continue to create bricks that clutter the metaphorical physical landscape and prevent the epigenetic landscape from being linked from the physiology of nutrient energy-dependent pheromone-controlled reproduction to all cell type differentiation via energy-dependent changes in atoms to ecosystems in all living genera. On 1/22/18, I discussed this with…

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Cryo-EM from atoms to ecosystems

October 6, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, RNA Directed
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Summary: I’m not going to continue repeating myself indefinitely. See: Reduced protein synthesis in schizophrenia patient-derived olfactory cells The reduced protein synthesis is a clear link from the virus-driven degradation of messenger RNA to all pathology. October 5, 2017 Lactate Metabolism in Human Lung Tumors Reported as: Study challenges long-standing concept in cancer metabolism “We were completely shocked by our findings,” said Dr. Ralph DeBerardinis, Professor at CRI, Director of CRI’s Genetic and Metabolic Disease Program, and Chief of the Division…

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