Cell Type

Military combat training to fight disease

Q: What is the extent of your formal scientific education? I see that you attended the University of Nevada at some point. A: I had already been trained in the military to combat evolutionary theory (see also Combating Evolution to Fight Disease). After time spent in the hospital medical records department, I became the liaison between people who were being processed for medical discharge and the Medical Evaluation Board, I organized case histories that included all testing and learned about…

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The biologically-based origin of the mammalian placenta (2)

See also: The biologically-based origin of the mammalian placenta I’ll preface this follow-up on the origins of the mammalian placenta with comments that attest to foolishness of theoretical physicists who try to link Big Bang cosmology to neo-Darwinian theories about mutations and evolution. RPF Interviews Dr. Alexander Unzicker Excerpt 1)  “It annoys me too much to see another generation of physicists deterred by the dumb messy patchwork called the standard model of particle physics, that hides the basic problems physics…

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Quantum Superpositions: let there be light

Ideal Negative Measurements in Quantum Walks Disprove Theories Based on Classical Trajectories Reported as: Atoms can be in two places at the same time Excerpt: “This is not yet a proof that quantum mechanics hold for large objects,” cautions Alberti. My comment: I framed my comments and a question in the context of this article on physics. Their claim of a possible size limit on quantum superpositions seemed to divorce top-down causation from cell–cell communication in mammals. That suggested there…

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Environment epigenetically shapes the immune system

Environment, more than genetics, shapes immune system 1) –with my emphasis Re: “There’s nothing here that is revolutionary or requires rethinking of our assumptions about how the immune system functions…” My comment: They removed assumptions about cell type differentiation by linking differences in metabolic networks to genetic networks. They indirectly showed that ecological adaptations are nutrient-dependent and the adaptations are controlled by the metabolism of nutrients to species-specific pheromones. The pheromones control the nutrient-dependent physiology of reproduction in species from…

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Constrained evolution is ecological adaptation

See also: Unconstrained evolutionary innovability Ideas that evolution is not constrained can be compared to experimental evidence of biophysically constrained ecological adaptations. The most recent relevant open access published work from the Jakobsson lab is: TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells. This is a link to a prior publication (also open access): microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons Taken together these two published works extend our 1996 model of RNA-mediated cell type differentiation…

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Unconstrained evolutionary innovability

The Strange Inevitability of Evolution by Philip Ball Excerpt 1)  Natural selection supplies an incredibly powerful way of pruning variation into effective solutions to the challenges of the environment. But it can’t explain where all that variation came from. As the biologist Hugo de Vries wrote in 1905, “natural selection may explain the survival of the fittest, but it cannot explain the arrival of the fittest.” Over the past several years, Wagner and a handful of others have been starting…

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From Hydra to humans vs a Lakatosian research program

Imre Lakatos Excerpt: “A Lakatosian research programme[8] is based on a hard core of theoretical assumptions that cannot be abandoned or altered without abandoning the programme altogether. More modest and specific theories that are formulated in order to explain evidence that threatens the ‘hard core’ are termed auxiliary hypotheses. Auxiliary hypotheses are considered expendable by the adherents of the research programme—they may be altered or abandoned as empirical discoveries require in order to ‘protect’ the ‘hard core’. Whereas Popper was…

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Communication, not mutations

Communicating Across Kingdoms? Researchers pinpoint microRNAs that could play a role in how Wolbachia bacteria manipulate their arthropod hosts. By Sandhya Sekar | December 15, 2014 Excerpt: “I am not sure that I would call this ‘communication,’ however,” he added, as the authors have in their paper. My comment: I’m rather certain that no evolutionary theorist will recognize this as communication because they typically claim mutations can be linked to increasing organismal complexity. This work indirectly links mutations to perturbed…

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Models by evolutionary biologists are not models

How Networks Are Revolutionizing Scientific (and Maybe Human) Thought By John Edward Terrell, Termeh Shafie and Mark Golitko | December 12, 2014 | Excerpt: “…evolutionary biologists are now modeling series of complex networked relationships at multiple levels ranging from individual “letters” in the genome to protein-gene networks to interaction networks between organisms, thereby demonstrating that our genes are only our destinies to the extent that they link to each other and to the surrounding world—both social and natural.” My comment: That’s…

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The future of physics predicts no future for evolutionary theory

The ever-smaller future of physics ‘Theory of everything’ captures Weinberg’s imagination in Lee Historical Lecture Excerpt: “…there are hints that the answers to fundamental questions will reveal themselves at around a million billionths — between 10­-17 and 10-19 — of the radius of the typical atomic nucleus. My comment: Evolutionary theorists may not recognize the problem that this presents. By accepting de Vries definition of “mutation” and rejecting experimental evidence, which links the epigenetic landscape to the physical landscape of…

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