cell types

Energy is information. Objections over ruled. You’re fired!

Objection: In the law of the United States of America, an objection is a formal protest raised in court during a trial to disallow a witness’s testimony or other evidence which would be in violation of the rules of evidence or other procedural law. Americanism (ideology) links the laws of United States of America to God’s “Laws of Biology.”  Pseudoscientists violated the rules of evidence that link Darwin’s “conditions of life” from God’s “Laws of Biology” to all nutrient energy-dependent…

Read More

Anthetical conclusions (2)

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster…

Read More

Q and A: Energy-dependent cell type differentiation

Richard Lenski and other theorists will not discuss the amount of pseudoscientific nonsense they have included in their ridiculous claims. Rarely does anyone else attempt to unravel their claims in the context of the reports I will cite below, or in other reports that refute ridiculous neo-Darwinian theories. Recently, however, Greg Thurston made an honorable effort to learn about energy-dependent biophysically constrained cause and effect via a series of questions that could be answered with minimal jargon. Q and A…

Read More

Life and death predicted by DNA methylation

The bounce rate here has more than doubled  (from 20% to 44%) during the past week at the same reports continue to support all the claims I have made about RNA-mediated cell type differentiation. Obviously, pseudoscientists are not willing to examine any evidence of biologically-based cause and effect that refutes their ridiculous claims about mutations and evolution. For comparison, serious scientists will want to read this: See: DNA methylation age is associated with mortality in a longitudinal Danish twin study…

Read More

Phenols: Laws of physics meet biology

Can the second law of thermodynamics hold in cell cultures? Excerpt: …for in vivo systems, the rules for self-organization require further investigations (Stuart, 1995), especially for multi-cellular organisms considering the exchange of matter between different cell types. Knowing this will allow us to better predict the emergent properties of the “real” living systems. My comment: When Jay R. Feierman realizes how ridiculous his comments about mutations and evolution have become, he posts  links to articles like this one to the…

Read More

Cell type differentiation: atoms to ecosystems

Relaxed genetic control of cortical organization in human brains compared with chimpanzees Abstract conclusion: A major result of increased plasticity is that the development of neural circuits that underlie behavior is shaped by the environmental, social, and cultural context more intensively in humans than in other primate species, thus providing an anatomical basis for behavioral and cognitive evolution. Reported as: Nature and nurture: Human brains evolved to be more responsive to environmental influences Excerpt: …the morphology of the human cerebral…

Read More

Models are not theories (1)

Cells or Animals: Which model is better? Excerpt: …animal models allow testing on intact physiological systems of many cell types simultaneously. Excerpt:  …it is important to note that human and rodent physiology is not identical, and even sophisticated animal models can have shortcomings. My comment: For comparison to neo-Darwinian theories, it is more important to note that the RNA-mediated cell type differentiation of all living genera is nutrient-dependent and controlled by the physiology of reproduction. Also note, in species from…

Read More

Exosomes and the RNA-mediated future of medicine (3)

September 11, 2015 Case Western Reserve scientists discover long-sought genetic mechanism for cancer progression Excerpt: Action of a key lncRNA different in colon cancer versus normal colon tissue My comment: In yet another ridiculous misrepresentation of all that is currently known about how the epigenetic landscape is linked to the physical landscape of DNA in all cell types of all individuals of all living genera, these researchers are reporting epigenetic links between metabolic networks and genetic networks as if the…

Read More

Olfaction & the octopus and human genomes

Secrets of the Deep: Scientists Sequence Genome of Octopus for First Time Excerpt: The genome was arranged differently than in other invertebrates and featured an expansion in a family of genes regulating nerve cell development that previously was thought to be enlarged only in vertebrates. My comment: RNA-mediated gene duplication and RNA-mediated amino acid substitutions link nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation to RNA-mediated  organism level thermoregulation in bacteria, yeasts, insects, marine invertebrates such as octopuses,  mammals, humans…

Read More

The stability of organized genomes (3)

See also: The stability of organized genomes; The stability of organized genomes (2) Nutrient-dependent/pheromone-controlled adaptive evolution: a model Excerpt from 6/14/13  …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. Global relationships in fluctuation and response in adaptive evolution Preprint pdf opens here Excerpt: It should…

Read More