cellular physiology

Polymaths and paradigm shifts: from Asimov to Bear (4)

Saying Goodbye to the RNA World Theory RNA has a limited ability for catalysis compared to peptides, and would have struggled to maintain its catalytic activity under the changing temperature conditions of early Earth. Carter and Wills also argued that if an RNA world existed, it would have been unlikely for it to incorporate peptides later on. See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)…

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RNA-mediated theory killers (6) (7) (8) (9) (10)

The Cost of Protein Production The cost of protein production is commonly attributed to protein translation (Andrews and Hegeman, 1976, Emilsson and Kurland, 1990, Kurland, 1992, Marr, 1991, Molin et al., 1974, Scott and Hwa, 2011, Scott et al., 2010, Vind et al., 1993). A major fraction of the cellular GTP pool is used for amino acid polymerization, while significantly lower quantities are invested in other processes including gene transcription and protein folding (Russell and Cook, 1995, Schimmel, 1993). Reported…

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