chimpanzee

Energy-dependent base editing and correction of mutations (1)

Summary: Food energy-dependent base editing has been linked to biophysically constrained viral latency via microRNA editing, RNA editing and the pheromone-controlled fixation of RNA-mediated amino acid substitutions in species from microbes to humans. Correction of β-thalassemia mutant by base editor in human embryos Conclusion: Intriguingly, we found that HBB −28 (A>G) mutation repairing efficiency was about 20% in the constructed cell line and primary skin fibroblast cells. Although 10.7% of the repaired skin fibroblast cells were heterozygous, it is still…

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New Testament Book Cover Refutes Theistic Evolution

Video of Biology of the Book Goats, bookworms, a monk’s kiss: Biologists reveal the hidden history of ancient gospels Collins already had developed a method to identify ancient species by differences in the amino acid sequences of collagen and other proteins preserved in fossils. See: Protein power by Robert F. Service …methods to sequence amino acids lag behind DNA sequencing. The report of 300 million year old proteins is based on ridiculous theories that failed to include what was known about…

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Science journalists or paid propagandists? (4)

See first: Dobzhansky 1973 and precision medicine Prognostic value of the MicroRNA-29 family in multiple human cancers: A meta-analysis and systematic review   ….low expression of miR-29 is associated with aggressiveness and poor prognosis of malignant neoplasms. More importantly, miR-29 might serve as a key biomarker for predicting the recurrence and progression of human cancers. Feeding on the Unseen: Ingestion and Assimilation of Bacteriophages by Brachionus plicatilis (Rotifera) ATP Production Increases with Addition of Varying Concentrations of Vespa Amino Acid Mixture…

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Energy-dependent de novo creation and neurogenesis (2)

See also: Energy-dependent de novo creation and neurogenesis 12/7/16 Atlas of the RNA universe takes shape Excerpt: MicroRNA are very mysterious. They are really relics of the RNA world—pieces of RNA that are highly reactive, very small and which pair and bind other RNA and facilitate catalytic reactions,” Mangone says. “We don’t know much about them—where they come from or how they regulate gene expression, but they are very misregulated in many diseases. See also: Nutrient-dependent/pheromone-controlled adaptive evolution: a model…

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Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of the β-globin cluster, we propose that the complex patterns of diversity observed in this genomic region arose from distinct functional constraints related with the intricate…

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Major transition ends use of silly theories

Major transitions in human evolution This theme issue focuses on key evolutionary transitions to understand the interaction of biology, behaviour, culture and environment. This issue is dedicated to Richard Leakey, whose critical discoveries have provided evidence for many of the key phases, and who has inspired much of the work discussed here. This issue is based on a joint Royal Society and British Academy discussion meeting held in October 2015. This issue is now available to read online. Reported as:…

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Energy-dependent biodiversity

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents Abstract excerpt: …the same activating principles used for decades to make simple C–N (amide) bonds from carboxylic acids with loss of water can be used to make C–C bonds… Conclusion: The ready availability of numerous carboxylic acids (which are easily converted to esters) contributes to the reaction’s versatility. My comment: Light energy-induced chemical reaction versatility links what is known about biophotonics to the physiology of energy-dependent pheromone-controlled reproduction in…

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Hydrogen-atom transfer in DNA base pairs (7)

Perry Marshall says: February 9, 2016 at 9:45 pm James, if you think you have a solution then fill out a proper prize submission and show that you have met the specification. My comment: There is no prize submission form and I repeatedly requested the Non-Disclosure Agreement. I think that Perry Marshall knows I will win the prize, and simply doesn’t want the challenge to his claims that I would provide in my submission.  For example, I would include citations…

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Assumptions prove ignorance (2)

Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome Conclusion: Hemochromatosis, known as the “Celtic” disease (44), is a variably penetrant recessive disorder, potentially fatal, due to excessive retention of dietary iron. It has been suggested that the high frequencies of both C282Y and H63D are due to heterozygote advantage related to nutritional advantage in Neolithic iron-poor diets (52), mitigation of celiac disease (53), and increased resistance to parasitic infection (54). To our knowledge, our…

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