Epigenetic facts vs variable recombination theories

6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Thanks again for asking about DNA methylation

Re: RNA-directed DNA methylation (1996) See: From Fertilization to Adult Sexual Behavior Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. See also: RNA-directed DNA methylation: an epigenetic…

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Fighting for virus-driven pathology

See my series of 5 posts on the tipping point, which was reached when more than 50,000 indexed publications mentioned microRNAs The tipping point? 50, 000 publications May 16, 2016 See also: MicroRNA analysis in mouse neuro-2a cells after pseudorabies virus infection A total of eight viral miRNA were identified, and ten host miRNAs showed significantly different expression upon PRV infection. Among these, five were analyzed by stem-loop RT-qPCR, which confirmed the above data. Interestingly, these viral miRNAs were mainly…

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Building delicious base pairs in class. It’s elementary Watson and Crick

 Candy DNA Building delicious A- T and G – C pairs This might be the best way to show students that base pair changes are nutrient energy-dependent and biophysically constrained by autophagy in the context of the physiology of reproduction, which links them to chromosomes as the units of transgenerational epigenetic inheritance. For example, the educator could start by telling them that if the base pair changes were not biophysically constrained by the chemistry of RNA-mediated protein folding, the…

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Imagining that data historically supports evolutionary theory

1) Arguments in the evo-devo debate: say it with flowers! Abstract excerpt: A key question in evolutionary developmental biology is how DNA sequence changes have directed the evolution of morphological diversity. The widely accepted view was that morphological changes resulted from differences in number and/or type of transcription factors, or even from small changes in the amino acid sequence of similar proteins. My comment: This is the first time I have seen anyone claim that the “…small changes in the…

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Military combat training to fight disease

Q: What is the extent of your formal scientific education? I see that you attended the University of Nevada at some point. A: I had already been trained in the military to combat evolutionary theory (see also Combating Evolution to Fight Disease). After time spent in the hospital medical records department, I became the liaison between people who were being processed for medical discharge and the Medical Evaluation Board, I organized case histories that included all testing and learned about…

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Mutagenesis: Replacing facts with theories

Never mind the selfish gene – ribosomes are the missing link Excerpt: “All cells share three organelles, or internal structures, besides gene-containing chromosomes: ribosomes which contain the machinery for translating genetic information into the proteins that perform the cell’s work; a cell membrane that selectively permits materials in and out; and acidocalcisomes, which store and regulate the ions that drive the chemical reactions of life.” In his criticisms of my model of cell type differentiation, Andrew Jones (aka anonymous_9001 in…

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A model of MHC 'evolution'

Sexual selection and the evolutionary dynamics of the major histocompatibility complex Excerpt: “Here, we present the results of the first model of MHC evolution incorporating both survival and reproduction, modelling the combined effects of natural selection and MHC-based disassortative mating on patterns of MHC allelic diversity.” My comment: Results from their first mathematical model can be compared to representations of biologically-based cause and effect in the context of our model. See From Fertilization to Adult Sexual Behavior. We linked RNA-mediated…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]