consciousness

Plenty of Room at the Bottom

Cryo-EM: Linking spatial and conformational constraints

February 13, 2018
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation
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On Darwin Day (2018) Carl Zimmer suggested use of the twitter hashtag #Istudyevolution to report whatever aspect of biology people were studying. For example, Richard Lenski reported that he studied adaptation in E. coli. When I told others that ecological adaptation is nutrient-dependent and pheromone-controlled in species from microbes to humans, he blocked me from seeing his comments. Evidently he did not want people to know that he had been studying ecological adaptation for more than 2 decades but reporting…

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Anti-entropic sunlight: Schrödinger’s Creationist Secret? (1)

February 1, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed, RNA-directed DNA methylation, Variations
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Summary: Perhaps Daniel Dennett will make people feel better about the unnecessary suffering and premature death. Daniel Dennett is scheduled to present the Keynote Lecture at Schrödinger at 75 – The Future of Biology – September 2018 For insight into his philosophical perspective see: How to Criticize with Kindness: Philosopher Daniel Dennett on the Four Steps to Arguing Intelligently 1) You should attempt to re-express your target’s position so clearly, vividly, and fairly that your target says, “Thanks, I wish…

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For God and Country

Kinetically Stable Thermodynamically Activated Cell Metabolism (4)

December 25, 2017
James Kohl
RNA Directed
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Experience-dependent pauses link the de novo creation of enzymes to the de novo creation of G protein-coupled receptors that link olfaction and the visual integration of other sensory input. That fact has been placed into the context of the “hard-problem” of consciousness. See: What makes mosquitoes attracted to Platanthera orchids? Delivering pulses of specific chemicals (EAGs) to the mosquitoes also provided a better understanding of the way orchids attract and use the mosquitoes to get pollinated. Interspecific differences among orchid…

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Food energy-dependent epigenetic adaptation

May 24, 2017
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations
One Comment

Mechanism of transmembrane signaling by sensor histidine kinases, was reported as Scientists investigate how the sense of smell works in bacteria …the signaling and inactive states differ only very slightly at the nitrate-binding site – by 0.5-1 angstroms, which is approximately one fifth of the size of the ion itself (1 angstrom is 10-10 meters). However, when this ion binds to the sensor, it causes huge changes in the protein: The helices of different monomers begin to move in different…

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Sal Giardina: apologetics revisited

March 27, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue with apologetics rather the concept of energy as information. Apologetics: … the religious discipline of defending or proving the truth of religious doctrines through systematic…

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Chromatin: The structure of DNA

September 19, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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Consciousness is simply food rearranged

September 19, 2016
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, Variations
One Comment

The claim that consciousness is simply food rearranged can be placed into a historical perspective that crosses more than 70 years. Historical perspective: (1944) What Is Life? Excerpt: Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded,…

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Hydrogen-atom energy in DNA base pairs

September 19, 2016
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, Variations
One Comment

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Anthetical conclusions (2)

August 19, 2016
James Kohl
RNA Directed
No Comments

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster…

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Nucleic acids: Stability of DNA/RNA

September 13, 2015
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, What's in the News
2 Comments

See also: RNA-mediated events and the “theory of everything.” Freeze-thaw cycles and nucleic acid stability: what’s safe for your samples? Conclusion: …you probably need to put a handful of your representative samples to the test in the context of your particular assay, to know what’s an acceptable number of freeze-thaw cycles for your purpose. My comment: Theoretical physicists and evolutionary theorists share a purpose. Their purpose is antithetical to accurate representations of what is known about the biologically-based stability of…

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