conserved molecular mechanisms

Virus-driven cystinosis

A friend asked about nephropathic cystinosis, which is a disease caused by the virus-driven theft of quantized energy. All serious scientists have linked viruses from the degradation of messenger RNA to mutations and all pathology. Nephropathic cystinosis (NC) is the most frequent cause of Fanconi syndrome (FS) in young children. It will be linked from the virus-driven degradation of messenger RNA to azoospermia and/or progressive neuromuscular degeneration via the conserved molecular mechanisms of RNA-mediated cell type differentiation compared to mechanisms…

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Bill Gates refutes theistic evolution (sequel)

See: Bill Gates refutes theistic evolution See also: Gate-controlled conductance switching in DNA Conclusion: Our work demonstrates one can introduce an active control to DNA conductance by modifying a base with a redox group, and switch the DNA conductance reversibly between two levels by oxidizing or reducing the redox group with an EC gate. This strategy could be implemented in more sophisticated DNA nanostructures for active device building blocks. As the DNA conductance is an indicator of the molecule in…

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Bill Gates refutes theistic evolution

See: Bill Gates refutes theistic evolution (prequel) See for comparison: Our 2017 Annual Letter Warren Buffett’s Best Investment By Bill and Melinda Gates | February 14, 2017 Malnourished children can be getting enough calories, but not the right nutrients. That makes them more susceptible to conditions like pneumonia or diarrhea—and more likely to die from them. If malnourished children are not getting the right nutrients, they focused too much on vaccines and not enough on what is known about nutritional…

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More refutations of neo-Darwinian nonsense

New CRISPR–Cas systems from uncultivated microbes In bacteria, we discovered two previously unknown systems, CRISPR-CasX and CRISPR-CasY, which are among the most compact systems yet identified. Notably, all required functional components were identified by metagenomics, enabling validation of robust in vivo RNA-guided DNA interference activity in E. coli. Interrogation of environmental microbial communities combined with in vivo experiments allows access to an unprecedented diversity of genomes whose content will expand the repertoire of microbe-based biotechnologies. They discovered that energy-dependent RNA-mediated…

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Explorers who do not know what is known (2)

See: Explorers who do not know what is known See also: Energy-dependent polycombic ecological adaptation Now see: The B/Z reaction, and the problem with peer review December 9. 2016 by John Leonard … oscillating chemical reactions predictable by mathematical formula are partially responsible for organizing cells to form organs, bone, and tissue. Alan Turing didn’t live to see the publication of evidence that would have validated his theory almost immediately. …when Belousov attempted to have his research published in 1951,…

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Nutrient-dependent pheromone-controlled autophagy (2)

See also: Nutrient-dependent pheromone-controlled autophagy Autophagy: cellular and molecular mechanisms (2010) Conclusion: … autophagy has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. My comment: Autophagy is energy-dependent and linked to supercoiled DNA by epigenetic effects on the innate immune system, which are linked to the physiology of energy-dependent reproduction. If you think that the innate immune system automagically “emerged,” you might also think that autophagy has automagically emerged as the…

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Nutrient-dependent pheromone-controlled autophagy

See also: Nutrient-dependent pheromone-controlled autophagy (2) The Excitable Mitochondria links 4 neurons from a nutrient energy-dependent pheromone-controlled network in a marine invertebrate to human brain development via the conserved molecular mechanisms that link the speed of light on contact with water to the de novo creation of G protein-coupled receptors (GPCRs).  Receptor-mediated species -specific chromatin remodeling links chromosomal rearrangements to all biodiversity via energy-dependent chemotaxis and phototaxis. See: The central pattern generator underlying swimming in Dendronotus iris: a simple half-center…

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A million dollar paradox?

Paradox at the heart of mathematics makes physics problem unanswerable Excerpt 1) Cubitt and his collaborators focused on calculating the ‘spectral gap’: the gap between the lowest energy level that electrons can occupy in a material, and the next one up. My comment: I hesitate to suggest that the problem of the spectral [energy] gap must be placed into the context of what is known about the speed of light on contact with water and how the anti-entropic energy of…

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Receptor methylation controls behavior

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Excerpt 1) The addition of a methyl group to an arginine residue can remove a hydrogen bond donor and decrease the electrostatic surface potential at the residue, resulting in a change in size and hydrophobicity that can affect its interaction with binding partners (21). Excerpt 2) Together, these results led us to propose that arginine methylation promotes D2-like dopamine receptor signaling and that this mechanism of receptor regulation is conserved…

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Nucleic acids: Stability of DNA/RNA

See also: RNA-mediated events and the “theory of everything.” Freeze-thaw cycles and nucleic acid stability: what’s safe for your samples? Conclusion: …you probably need to put a handful of your representative samples to the test in the context of your particular assay, to know what’s an acceptable number of freeze-thaw cycles for your purpose. My comment: Theoretical physicists and evolutionary theorists share a purpose. Their purpose is antithetical to accurate representations of what is known about the biologically-based stability of…

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