cryo-electron microscopy

Plenty of Room at the Bottom

Cryo-EM: Linking spatial and conformational constraints

On Darwin Day (2018) Carl Zimmer suggested use of the twitter hashtag #Istudyevolution to report whatever aspect of biology people were studying. For example, Richard Lenski reported that he studied adaptation in E. coli. When I told others that ecological adaptation is nutrient-dependent and pheromone-controlled in species from microbes to humans, he blocked me from seeing his comments. Evidently he did not want people to know that he had been studying ecological adaptation for more than 2 decades but reporting…

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Quantized energy-dependent viral trophism

…mutations cause activation of your death gene. Conclusion: You may be able to stop the ongoing activation of your death gene by a change in diet. See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases ——————————————– Daniel L.Hurdiss (@DanielHurdiss) announced publication of this refutation of neo-Darwinian pseudoscientific nonsense in his twitter feed before the…

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Electron cloud superimposed on the yin yang symbol

The “walking fish” walks straight from quantum physics to quantum souls (4)

Excerpt: During the past 21 months, others have either learned nothing about microRNAs or they have ignored the fact that virus-driven energy theft is not the same as energy dissipation in the context of food energy (the quantized energy as information that is used by viruses to create the amino acid substitutions that stabilize their RNA and DNA). The dark side of the new popularity of cryo-electron microscopy …we need to stand together as a field, and support our colleagues…

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Predicting who wins the 2017 Nobel Prizes (6)

I failed to correctly predict who would win this year’s Nobel Prize in Chemistry, but there is still hope for my prediction of who will win the Nobel Peace Prize. I thought Lynn Zechiedrich would win for linking cryo-EM to the Structural diversity of supercoiled DNA Our cryo-ET, biochemical, and computational studies show the astounding versatility and dynamism of DNA depending on the degree of supercoiling. DNA simultaneously exists in a largely inactive B-form with bases tucked in and protected…

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Energy-dependent epigenetic translation to mRNA stability (5)

Energy-dependent epigenetic translation to mRNA stability (4) From Fertilization to Adult Sexual Behavior Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. See also: The Supraspliceosome – A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus Abstract conclusion: …changes in these regulatory processing activities are associated with human disease and cancer. These findings emphasize the supraspliceosome as…

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