RNA-Mediated

See first: Naturally attenuated viral endemicity (7) “MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly 11/19/21 …we describe a new role for miR-101-3p as a modulator of mitochondrial metabolism via its regulation of multiple mitochondrial processes, including mtDNA transcription and complex II biogenesis.” See also: Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function 11/24/21 Exposure to long wavelength light (650–900 nm) in animals improves mitochondrial function, increasing ATP production and…

pH-dependent viral latency (2)

May 24, 2020

Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, What's in the News

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20 See for comparison: Vaccines do not control pandemics (1) 5/15/20 I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18 Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes48. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96…

Virus-driven downsizing of the human brain (6)

March 3, 2019

Adaptations, Cytosis, Diseases & Disorders, Ecology, RNA Directed, Subatomic

See first: Virus-driven downsizing of the human brain (5) Scientists may need to seriously reconsider the cast-aside hypothesis that pathogens can play a part in diseases such as Alzheimer’s and Parkinson’s. 3/1/19 “Viruses are often ignored in relation to neurodegenerative diseases,” Yale University neurobiologist Anthony van den Pol tells The Scientist. “That’s in part because there’s no clear sign that a virus causes a neurodegenerative disease. But it might.” Some viruses can enter the body through the nose and mouth…

NHEJ disruption and HDR correction?

June 14, 2018

Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, What's in the News

International Workshop “Targeting RNA world” Dear colleagues! Scientists of the Institute of Chemical Biology and Fundamental Medicine SB RAS cordially invites you to attend International Workshop “Targeting RNA world” in the frame of the project of Russian Scientific Foundation “New generation of RNA-targeting oligonucleotide derivatives as a platform for designing innovative therapeutics” (no. 14-44-00068). Workshop is being held in Park Inn by Radisson Pulkovskaya Hotel & Conference Centre St Petersburg, Saint-Petersburg, Russia, September 2-7 2018. We will discuss all aspects…

Death cures theorist’s Amyotrophic Lateral Sclerosis (ALS).

March 15, 2018

Alternative Splicings, Autophagy, Diseases & Disorders, Human Brain, Neuronal Plasticity, Physics, RNA-mediated toxicity, Variations, What's in the News

Stephen Hawking death: Was he the smartest man in the world? The media need superheroes in science just as in every sphere of life, but there is really a continuous range of abilities with no clear dividing line. For comparison: Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) A pathogenic mutation in D-amino acid oxidase (DAO) associated with familial ALS impairs D-serine metabolism and causes protein aggregation, autophagy and cell death…

Conceptual critique: Innateness vs the death gene (1)

February 14, 2018

Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations

Summary: The term innate is used in psychological explanations. The so-called explanations ignore facts about the light energy-dependent activation of endogenous substrates. The anti-entropic virucidal energy of sunlight links the endogenous substrates to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in all living genera. “Proximate mechanisms” and “evolution” are terms used by biologically uninformed theorists. That fact becomes perfectly clear in the context of The conceptual critique of innateness (paywalled) One proposal is that innateness can…

http://nnjournal.net/article/viewFile/2354/1850/10234

Diet-driven RNA interference and mental health (2)

January 26, 2018

Adaptations, Alternative Splicings, Autophagy, base editing, Diseases & Disorders, Ecology, RNA Directed

The diet-driven construction of the competing endogenous RNA networks (ceRNA networks) is energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. Viruses compete for the energy, which is how they contribute to the degradation of messenger RNA that all serious scientists have linked to all mental and physical pathology. Cell death is not just seen in the context of autophagy and neural cell death. The pathogens that alter physiology also alter behavior via the conserved molecular mechanisms of energy-dependent…

Quantized energy-dependent viral trophism

January 4, 2018

Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, What's in the News

…mutations cause activation of your death gene. Conclusion: You may be able to stop the ongoing activation of your death gene by a change in diet. See: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene See also: A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases ——————————————– Daniel L.Hurdiss (@DanielHurdiss) announced publication of this refutation of neo-Darwinian pseudoscientific nonsense in his twitter feed before the…

Reporting new scientific truths is not allowed in the USA

November 29, 2017

Adaptations, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA editing, RNA methylation, RNA-directed DNA methylation, Variations

Summary: If we keep training serious scientists in the United States but force them to return to their homeland to report new scientific truths, our Homeland Security will suffer from the ignorance of pseudoscientists who are still touting ridiculous claims about mutations and evolution. A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it. Every…

Who created your virus-driven death gene? (1)

November 23, 2017

Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, RNA Directed