Denis Noble

Anti-entropic energy and the “Music of Life”

TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells … we report the existence of a TRIM28-controlled gene regulatory network based on ERVs that is active in hNPCs. Our findings open up for several exciting future studies on the role of ERVs as potential drivers of human brain evolution, their contribution to individual variation, and the implication in human brain disorders. All gene regulatory networks are energy-dependent. They must link the sun’s anti-entropic virucidal…

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RNA methylation (2)

Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus Several studies have provided evidence suggesting that “placebo effects” represent conditioning phenomena and that learning processes influence the response to placebo medication. This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli. The regimen was based on conditioning experiments with animals who had lupuslike autoimmune disease. After the initial pairings, the taste alone…

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Masters of deception about nature

Masters of Physics in Nature Excerpt: This interaction raises the possibility that particle velocity information and electrical information, and interactions between them, can be encoded by a single hair.” It also raises the possibility that “electroreception is widespread in arthropods, fulfilling functions beyond the detection of floral electric fields. My comment: Energy-dependent microRNA flanking sequences linked all invertebrates to all vertebrates in the context of what was published as:  The phylogenetic utility and functional constraint of microRNA flanking sequences and…

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RNA Mediated

Metaphysical science vs theory

I’ve wasted too much time attempting to explain biologically-based facts to the biologically uninformed discussants on Science X network. This is an attempt to salvage some of the time and to move forward.  See: New comments posted on Science X network: – A natural history of neurons: Diverse mutations reveal lineage of brain cells : 1 new comment – Study sheds light on powerful process that turns food into energy : 1 new comment – Study adds to evidence that…

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Protein folding and Google page rank

Pheromones.com has been on the first page of a Google search for “pheromones” for several months. See: https://www.google.com/?gws_rd=ssl#q=pheromones Today, RNA-mediated.com appeared on the first page of a Google search for “RNA mediated” See: https://www.google.com/?gws_rd=ssl#q=RNA+mediated My domains may remain in a key position for information dissemination, or they may be placed into the background by Google’s algorithms. In either case, it has become clear that RNA-mediated events link the nutrient-dependent pheromone-controlled physiology of reproduction to biodiversity in species from microbes to…

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Nutrient-dependent RNA interference

This David Sloan Wilson interview of Eva Jablonka reflects the desperation of evolutionary theorists. Jablonka claims there is no need to re-define “evolution.” She also places all prior claims about evolution into the context of “symbolic evolution.” She attests to the fact that “evolution” (e.g., change over time) will probably be re-defined to fit whatever anyone was taught to believe it might be. See: Beyond Genetic Evolution. A Conversation With Eva Jablonka Excerpt: “This is a good opportunity to move…

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Jumping back: Science or Pseudoscience?

Daily Comment November 21, 2014 European Science’s Great Leap Backward By Michael Specter Excerpt 1) “When politicians reject verifiable data and reputable research and rely instead on politics or desire, the results can be devastating.” Excerpt 2 with my emphasis) “…scientific organizations from around the world… have strongly endorsed the safety of G.M. foods. (It should be noted that the U.S. can claim no superiority in our approach to evidence-based science, as demonstrated by the fact that nearly half of…

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Dual genomes: exposing the evolution industry

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes Excerpt: “The CDP showed a significant overrepresentation of certain gene ontology (GO) groups (global tests Po0.001–0.009), using the programme FUNC23 (Methods). These groups included GPCRs, in particular olfactory receptors (ORs), and other membrane and cell-surface proteins, as well as proteins related to the immune system, such as the MHC (Class I and II), and drug metabolism…” My comment: Biodiversity “…converges upon a ‘common diplotypic proteome (CDP)’, a distinctive subset…

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